公开(公告)号：US20050262270A1

公开(公告)日：2005-11-24

申请号：US10851246

申请日：2004-05-24

申请人： Fernando Latorre ,  Jose Gonzalez ,  Antonio Gonzalez

发明人： Fernando Latorre ,  Jose Gonzalez ,  Antonio Gonzalez

IPC分类号： G06F1/32 ,  G06F3/00 ,  G06F9/38

CPC分类号： G06F1/32 ,  G06F9/3836 ,  G06F9/3851 ,  G06F9/3891

摘要： A multithreaded clustered microarchitecture with dynamic back-end assignment is presented. A processing system may include a plurality of instruction caches and front-end units each to process an individual thread from a corresponding one of the instruction caches, a plurality of back-end units, and an interconnect network to couple the front-end and back-end units. A method may include measuring a performance metric of a back-end unit, comparing the measurement to a first value, and reassigning, or not, the back-end unit according to the comparison. Computer systems according to embodiments of the invention may include: a random access memory; a system bus; and a processor having a plurality of instruction caches, a plurality of front-end units each to process an individual thread from a corresponding one of the instruction caches; a plurality of back-end units; and an interconnect network coupled to the plurality of front-end units and the plurality of back-end units.

摘要翻译： 提出了具有动态后端分配的多线程集群微架构。 处理系统可以包括多个指令高速缓存和前端单元，每个指令高速缓存和前端单元各自处理来自指令高速缓存中的相应一个的单独线程，多个后端单元和互连网络以耦合前端和后端 -end单位。 方法可以包括测量后端单元的性能度量，将测量与第一值进行比较，以及根据比较重新分配或不再分配后端单元。 根据本发明的实施例的计算机系统可以包括：随机存取存储器; 系统总线 以及具有多个指令高速缓存的处理器，多个前端单元，每个前端单元各自处理来自所述指令高速缓存中的相应一个的各个线程; 多个后端单元; 以及耦合到所述多个前端单元和所述多个后端单元的互连网络。

公开(公告)号：US6087491A

公开(公告)日：2000-07-11

申请号：US827561

申请日：1997-05-02

申请人： Jin-Yan Tang ,  Nandkumar Bongle ,  Jose Gonzalez ,  Warren E. Schwartz

发明人： Jin-Yan Tang ,  Nandkumar Bongle ,  Jose Gonzalez ,  Warren E. Schwartz

IPC分类号： C07H21/00

CPC分类号： C07H21/00

摘要： The present invention comprises an improved method of synthesizing oligonucleotides. The method comprises employing dinucleotides (or "dimer blocks") as the basic synthetic unit building block. The method results in extremely high purity oligonucleotides in which the N-1 content is very low, generally less than 1-2% of the full length, N, oligonucleotide. We have found that synthesis using dinucleotide phosphorothioates results in oligonucleotides having very little phosphodiester content. Furthermore, we have found that the amount of dimer required in each coupling step can be less than about 6 and is preferably about 2 equivalents. Synthesis of oligonucleotides according to the dimer block approach described herein can also be conducted without the capping step that has heretofore been deemed necessary after each coupling.

摘要翻译： 本发明包括一种合成寡核苷酸的改进方法。 该方法包括使用二核苷酸（或“二聚体嵌段”）作为基本合成单元结构单元。 该方法产生非常高纯度的寡核苷酸，其中N-1含量非常低，通常小于全长N，寡核苷酸的1-2％。 我们已经发现，使用二核苷酸硫代磷酸酯的合成导致寡核苷酸具有非常少的磷酸二酯含量。 此外，我们已经发现，每个偶联步骤中所需的二聚体的量可以小于约6，优选约为2当量。 根据本文所述的二聚体嵌段方法的寡核苷酸的合成也可以在每次偶联之前已经被认为是必要的封端步骤的情况下进行。

公开(公告)号：USD329493S

公开(公告)日：1992-09-15

申请号：US570712

申请日：1990-08-23

申请人： Jose Gonzalez

设计人： Jose Gonzalez