公开(公告)号：US07390311B2

公开(公告)日：2008-06-24

申请号：US10903599

申请日：2004-07-30

申请人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

发明人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

IPC分类号： A61M31/00

CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2230/00 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/3962

摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).

摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西汀，脱甲基丸，美托咪定和 右美托咪定）。

公开(公告)号：US06380738B1

公开(公告)日：2002-04-30

申请号：US09469864

申请日：1999-12-22

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： G01V300

CPC分类号： G01R33/56563

摘要： A magnetic resonance (MR) imaging system including a method and apparatus for reducing image artifacts caused by magnet vibration is disclosed herein. The system includes a magnetic field vibration quantification and compensation scheme including quantifying a vibration error component included in the magnetic field configured to acquire k-space data corresponding to an MR image, and correcting the k-space data using the vibration error component. The vibration-induced magnetic field perturbation includes a spatially invariant magnetic field, a spatially linear readout magnetic field gradient, a spatially linear phase-encoding magnetic field gradient, and a spatially linear slice-selection magnetic field gradient. The vibration error component can be at least one of a spatially independent phase error of the spatially invariant magnetic field, a kx-space displacement error of the spatially linear readout magnetic field gradient, a ky-space displacement error of the spatially linear phase-encoding magnetic field gradient, and a slice-selection error of the spatially linear slice-selection magnetic field gradient.

摘要翻译： 本文公开了包括用于减少由磁体振动引起的图像伪像的方法和装置的磁共振（MR）成像系统。 该系统包括磁场振动量化和补偿方案，包括量化包括在磁场中的振动误差分量，该磁场被配置为获取与MR图像相对应的k空间数据，以及使用振动误差分量校正k空间数据。 振动诱导磁场扰动包括空间不变磁场，空间线性读出磁场梯度，空间线性相位编码磁场梯度和空间线性切片选择磁场梯度。 振动误差分量可以是空间不变的磁场的空间上独立的相位误差，空间线性读出磁场梯度的k×空间位移误差，空间线性相位编码的ky-空间位移误差中的至少一个 磁场梯度，以及空间线性切片选择磁场梯度的切片选择误差。

公开(公告)号：US06329821B1

公开(公告)日：2001-12-11

申请号：US09468960

申请日：1999-12-22

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： G01V300

CPC分类号： G01R33/56563

摘要： A magnetic resonance (MR) imaging system including a method and apparatus for reducing image artifacts caused by magnet vibration is disclosed herein. The system includes a magnetic field vibration quantification and compensation scheme including correcting for a vibration error induced in k-space data corresponding to an MR image. The vibration error can be at least one of a spatially independent phase error caused by a spatially invariant magnetic field, a kx-space displacement error caused by a perturbation gradient along the readout direction, a ky-space displacement error caused by a perturbation gradient along the phase-encoding direction, and a slice-selection error caused by a perturbation gradient along the slice-selection direction. The vibration error is used to appropriately modify and/or add to its corresponding magnetic field component, or its equivalent, in the pulse sequence.

摘要翻译： 本文公开了包括用于减少由磁体振动引起的图像伪像的方法和装置的磁共振（MR）成像系统。 该系统包括磁场振动量化和补偿方案，包括校正与MR图像相对应的k空间数据中引起的振动误差。 振动误差可以是由空间不变磁场引起的空间上独立的相位误差中的至少一个，沿着读出方向的扰动梯度引起的k×空间位移误差，由沿着读出方向的扰动梯度引起的ky-空间位移误差 相位编码方向以及沿着切片选择方向的扰动梯度引起的切片选择误差。 振动误差用于在脉冲序列中适当地修改和/或添加到其对应的磁场分量或其等效物。

公开(公告)号：US06323646B1

公开(公告)日：2001-11-27

申请号：US09316230

申请日：1999-05-21

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff ,  Hammond Glenn Reynolds

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff ,  Hammond Glenn Reynolds

IPC分类号： G01V300

CPC分类号： G01R33/56341

摘要： A technique is provided for generating images on an MRI system in which errors due to gradient pulses are compensated. The errors are identified in advance, such as in a calibration sequence performed on the MRI system. Receiver phase adjustment and logical gradient error values are derived from the identified error values. The calibration sequence may be a modified version of the MRI imaging sequence used to produce the images. The correction values may be based upon corrections at the center of k-space. The technique is particularly useful in compensating for effects of eddy currents in pulse sequences employing high slew rate gradient pulses, such as diffusion weighted echo planar imaging sequences.

摘要翻译： 提供了一种用于在MRI系统上生成图像的技术，其中补偿了由于梯度脉冲引起的误差。 错误是事先确定的，例如在MRI系统上执行的校准序列。 接收器相位调整和逻辑梯度误差值是从识别的误差值导出的。 校准序列可以是用于产生图像的MRI成像序列的修改版本。 校正值可以基于在k空间中心的校正。 该技术在补偿使用高压摆率梯度脉冲（例如扩散加权回波平面成像序列）的脉冲序列中对涡流的影响特别有用。

公开(公告)号：US6070095A

公开(公告)日：2000-05-30

申请号：US089205

申请日：1998-06-02

申请人： Graeme C. McKinnon ,  Xiaohong Zhou

发明人： Graeme C. McKinnon ,  Xiaohong Zhou

IPC分类号： G01R33/565 ,  A61B5/055

CPC分类号： G01R33/56509

摘要： A method is provided for correcting for effects of translational motion or movement of an object in MR imaging. In accordance with the method, an MR point source is joined to the object for translational movement in unison therewith, the point source being maintained in selectively spaced-apart relationship with the object. The method further comprises acquiring a set of k-space data representing images of the object and point source collectively, and deriving a function representing the square of the magnitude of the k-space data set. An inverse Fourier transform operation is applied to the derived function to generate a correlation function with a number of correlation components, a specified one of the correlation components comprising the cross-correlation of the object and the point source. All of the correlation components are then discarded, except for the specified correlation component, which provides an adjusted MR image representing the object from which effects of the translational motion have been substantially eliminated.

摘要翻译： 提供了一种用于校正MR成像中的物体的平移运动或运动的影响的方法。 根据该方法，MR点源被连接到对象以与其一致地进行平移运动，点源保持与对象的选择性间隔关系。 该方法进一步包括：一组获取表示该对象和点源的图像的一组k空间数据，以及导出表示该k空间数据集的大小的平方的函数。 对衍生函数应用逆傅里叶变换操作以产生具有多个相关分量的相关函数，所述相关分量包括对象和点源的互相关的相关分量中的指定的一个。 除了指定的相关分量之外，所有相关分量被丢弃，该相关分量提供了表示已经基本上消除了平移运动的影响的对象的经调整的MR图像。

公开(公告)号：US06064205A

公开(公告)日：2000-05-16

申请号：US265259

申请日：1999-03-09

申请人： Xiaohong Zhou ,  Yiping Du ,  Matthew A. Bernstein ,  Hammond G. Reynolds ,  Joseph K. Maier ,  Jason A. Polzin

发明人： Xiaohong Zhou ,  Yiping Du ,  Matthew A. Bernstein ,  Hammond G. Reynolds ,  Joseph K. Maier ,  Jason A. Polzin

IPC分类号： G01R33/32 ,  A61B5/055 ,  G01R33/54 ,  G01R33/561 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56581 ,  G01R33/56554

摘要： Two methods are disclosed to remove the image artifacts produced by Maxwell terms arising from the imaging gradients in an echo planar imaging pulse sequence. In the first method, the frequency and phase errors caused by the Maxwell terms are calculated on an individual slice basis and subsequently compensated during data acquisition by dynamically adjusting the receiver frequency and phase. In the second method, two linear phase errors, one in the readout direction and the other in the phase-encoding direction, both of which arise from the Maxwell terms, are calculated on an individual-slice basis. These errors are compensated for in the k-space data after data acquisition.

摘要翻译： 公开了两种方法来去除由回波平面成像脉冲序列中的成像梯度引起的由麦克斯韦尔产生的图像伪影。 在第一种方法中，由麦克斯韦尔项引起的频率和相位误差在单独的切片基础上计算，并随后通过动态调整接收机频率和相位在数据采集期间进行补偿。 在第二种方法中，以单个切片为基础计算两个线性相位误差，一个在读出方向上，另一个在相位编码方向上，两个来自麦克斯韦术语。 这些误差在数据采集后的k空间数据中得到补偿。

公开(公告)号：US6043656A

公开(公告)日：2000-03-28

申请号：US197858

申请日：1998-11-23

申请人： Jingfei Ma ,  Xiaohong Zhou ,  Graeme C. McKinnon

发明人： Jingfei Ma ,  Xiaohong Zhou ,  Graeme C. McKinnon

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56518

摘要： An MRI system includes a gradient compensation system which appends magnetization reset gradient waveforms to imaging gradient waveforms produced during a scan. The magnetization compensation gradients maintain the residual magnetization in the MRI system at a constant level which reduces image artifacts.

摘要翻译： MRI系统包括梯度补偿系统，其将磁化复位梯度波形附加到在扫描期间产生的成像梯度波形。 磁化补偿梯度将MRI系统中的剩余磁化强度保持在恒定水平，从而降低图像伪影。

公开(公告)号：US5923168A

公开(公告)日：1999-07-13

申请号：US877384

申请日：1997-06-17

申请人： Xiaohong Zhou ,  Yiping Du ,  Matthew A. Bernstein ,  Hammond G. Reynolds ,  Joseph K. Maier ,  Jason A. Polzin

发明人： Xiaohong Zhou ,  Yiping Du ,  Matthew A. Bernstein ,  Hammond G. Reynolds ,  Joseph K. Maier ,  Jason A. Polzin

IPC分类号： G01R33/32 ,  A61B5/055 ,  G01R33/54 ,  G01R33/561 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56581 ,  G01R33/56554

摘要： A method is disclosed to remove the image artifacts produced by Maxwell terms arising from the imaging gradients in an echo planar imaging pulse sequence. The frequency and phase errors caused by the Maxwell terms are calculated on an individual slice basis. During the subsequent data acquisition these errors are compensated by dynamically adjusting the receiver frequency and phase.

摘要翻译： 公开了一种消除由回波平面成像脉冲序列中的成像梯度产生的麦克斯韦术语产生的图像伪影的方法。 由麦克斯韦条款引起的频率和相位误差是在单独的切片基础上计算的。 在随后的数据采集过程中，通过动态调整接收机频率和相位来补偿这些误差。

公开(公告)号：US5917323A

公开(公告)日：1999-06-29

申请号：US886830

申请日：1997-07-01

申请人： Yping Du ,  Xiaohong Zhou ,  Matthew A. Bernstein ,  Joseph K. Maier

发明人： Yping Du ,  Xiaohong Zhou ,  Matthew A. Bernstein ,  Joseph K. Maier

IPC分类号： G01R33/48 ,  A61B5/055 ,  G01R33/561 ,  G01R33/565 ,  G06Q50/00 ,  G06T1/00 ,  G01V3/175

CPC分类号： G01R33/56581 ,  G01R33/56554

摘要： Signal fall-off in axial EPI images as well as its variations is corrected by compensating the EPI pulse sequence with gradient pulses that serve to balance the phase dispersion caused by Maxwell terms. Four embodiments are described which employ the slice-selection gradient to compensate the EPI pulse sequence and a fifth embodiment employs the readout gradient.

摘要翻译： 通过用梯度脉冲补偿EPI脉冲序列来校正轴向EPI图像中的信号脱落及其变化，以平衡由麦克斯韦术引起的相位色散。 描述采用切片选择梯度补偿EPI脉冲序列的四个实施例，第五实施例采用读出梯度。

公开(公告)号：US5770943A

公开(公告)日：1998-06-23

申请号：US777561

申请日：1996-12-30

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： G01R33/387 ,  A61B5/055 ,  G01N20060101 ,  G01R33/20 ,  G01R33/421 ,  G01R33/48 ,  G01V3/00

CPC分类号： G01R33/56518

摘要： A calibration scan is used to acquire a test data set from which eddy currents induced by a test gradient pulse can be both spatially and temporally resolved. Compensation parameters are calculated and used to offset the measured eddy currents.

摘要翻译： 校准扫描用于获取由测试梯度脉冲引起的涡流可以在空间和时间上分辨的测试数据集。 计算补偿参数并用于抵消测量的涡流。