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公开(公告)号：US20050154001A1
公开(公告)日：2005-07-14
申请号：US11028281
申请日：2005-01-03
IPC分类号： C07D471/10 , A61K31/4747
CPC分类号： C07D471/10
摘要： The present invention relates to compounds of formula wherein A-B is —CH2—CH2—, —CH2—O— or —O—CH2—; X is hydrogen or hydroxy; R1 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, cyano, CF3, —OCF3, lower alkoxy, —SO2-lower alkyl and heteroaryl; R2 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, CF3, and lower alkoxy; R3 is hydrogen or lower alkyl; n is 0, 1 or 2; or a pharmaceutically active salt thereof. The compounds of the invention may be used in the treatment of neurological and neuropsychiatric disorders.
摘要翻译： 本发明涉及下式的化合物其中AB是-CH 2 -CH 2 - ， - CH 2 -O - 或-O- CH 2 - ; X是氢或羟基; R 1是芳基，任选被一个或两个选自卤素，低级烷基，氰基，CF 3，-OCF 3， 低级烷氧基，-SO 2 - 低级烷基和杂芳基; R 2是任选被一个或两个选自卤素，低级烷基，CF 3 N 3和低级烷氧基的取代基取代的芳基; R 3是氢或低级烷基; n为0,1或2; 或其药物活性盐。 本发明的化合物可用于治疗神经和神经精神障碍。
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公开(公告)号：US06799032B2
公开(公告)日：2004-09-28
申请号：US09816682
申请日：2001-03-23
申请人： James Thomas Edward McDonnell , Andrew Thomas , Michael P. Spratt , John Deryk Waters , Simon E. Crouch
发明人： James Thomas Edward McDonnell , Andrew Thomas , Michael P. Spratt , John Deryk Waters , Simon E. Crouch
IPC分类号： H04M166
摘要： A mobile entity (20) provides accuracy limit data (Q) that indicates a desired accuracy of location data (L) about the mobile entity. This data (Q) is passed, either directly or indirectly from the mobile entity (20), to a location handling system (80) which provides location data (L) about the corresponding mobile entity limited to the desired accuracy. In one embodiment, the location handling system is a location server. In another embodiment the location handling system is a decryption entity (80) for decrypting encrypted location data.
摘要翻译： 移动实体（20）提供指示关于移动实体的位置数据（L）的期望精度的精度限制数据（Q）。 该数据（Q）直接地或间接地从移动实体（20）传递到位置处理系统（80），该位置处理系统（80）提供关于限制到期望精度的相应移动实体的位置数据（L）。 在一个实施例中，位置处理系统是位置服务器。 在另一个实施例中，位置处理系统是用于解密加密位置数据的解密实体（80）。
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公开(公告)号：US06549142B2
公开(公告)日：2003-04-15
申请号：US09994935
申请日：2001-11-28
申请人： Andrew Thomas , Stephen John Hinde , Martin Sadler
发明人： Andrew Thomas , Stephen John Hinde , Martin Sadler
IPC分类号： G08B2100
CPC分类号： G08B25/008 , G08B3/1083 , G08B13/2491
摘要： Audio alerts are provided in an environment, such as a house, concerning categorized events to be reported. Examples of the events are receipt of e-mails and voice mails. The presence of a person entering or leaving a space of the environment is detected and a processing system determines reportable event categories that have occurred. Each possible event category has a corresponding audio signature. The event categories signatures that have occurred are played either simultaneously or sequentially, within the hearing of the person detected.
摘要翻译： 音频警报在诸如房屋的环境中提供，涉及要报告的分类事件。 事件的例子是收到电子邮件和语音邮件。 检测进入或离开环境空间的人的存在，并且处理系统确定已发生的可报告事件类别。 每个可能的事件类别都有相应的音频签名。 发生的事件类别签名在被检测者的听力内同时或顺序播放。
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公开(公告)号：US12022894B2
公开(公告)日：2024-07-02
申请号：US17693050
申请日：2022-03-11
申请人： Andrew Thomas
发明人： Andrew Thomas
CPC分类号： A41D13/0012 , A41D2400/46 , A45F2003/166
摘要： A compression garment with an integrated receptacle that provides liquid to a user is disclosed. The compression garment has at least one exterior cavity for receiving a receptacle and at least one tube channel with tube channel openings for receiving the tube from the exterior cavity and to route the tube across the chest of a user and into a webbing loop. An o-ring that locks a breakable foil seal in place is provided when a spout is connected to the neck element and the spout secures the liquid in the reservoir by compressing the o-ring on the foil seal. A grab ridge is then used to release the reservoir from the cavity of the compression garment as desired by the user.
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公开(公告)号：US09646280B2
公开(公告)日：2017-05-09
申请号：US10584417
申请日：2005-01-25
申请人： Andrew Thomas
发明人： Andrew Thomas
CPC分类号： G06Q10/08 , G06Q10/00 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A system and method for managing the delivery of goods. The system and method particularly provides for manifesting and controlling route-based delivery of orders or packages from a vendor to one or more locations accessible by customers. The locations may include automated, self-service vending machines and/or will-call lockers, under the control of a system (ideally centralized and automated) that can receive and actively manage manifest information.
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126.发明授权公开(公告)号：US09007053B2
公开(公告)日：2015-04-14
申请号：US13435706
申请日：2012-03-30
申请人： Andrew Thomas
发明人： Andrew Thomas
CPC分类号： G01N27/9046
摘要： Disclosed is an eddy current non-destructive inspection device which includes an eddy current probe with a probe conductor resistance dynamically changing due to operation conditions, such as temperature. The device further includes a signal generating circuit generating an inspection frequency signal and a low frequency signal. Sensed inspection frequency signals are processed to produce resulting signals with possible drift. A low frequency processing circuit includes a resistance calculator producing a substantially true value of the dynamic probe resistance, based on which compensation operations are configured to correct the drifted resulting signals and produce corrected resulting signals.
摘要翻译： 公开了一种涡流无损检测装置，其包括具有探针导体电阻的涡流探针，其由于诸如温度的操作条件而动态变化。 该装置还包括产生检查频率信号和低频信号的信号发生电路。 检测到的检测频率信号被处理以产生可能漂移的结果信号。 低频处理电路包括电阻计算器，其产生基本上真实的动态探针电阻值，基于该电阻计算器补偿操作被配置为校正漂移的结果信号并产生校正后的结果信号。
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公开(公告)号：US08319545B2
公开(公告)日：2012-11-27
申请号：US12711828
申请日：2010-02-24
申请人： Joseph Sousa , Andrew Thomas
发明人： Joseph Sousa , Andrew Thomas
IPC分类号： G05F1/10
摘要： Circuits and methods for maintaining a substantially constant input and output current for a charge pump circuit are provided which reduce current variation during switching intervals. The charge pump circuitry of the present invention maintains a current flow path from a current source to the charge pump output which minimizes or eliminates spikes normally associated with the switching intervals.
摘要翻译： 提供了用于为电荷泵电路保持基本恒定的输入和输出电流的电路和方法，其减少了切换间隔期间的电流变化。 本发明的电荷泵电路保持从电流源到电荷泵输出的电流流动路径，其最小化或消除通常与切换间隔相关联的尖峰。
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公开(公告)号：US20120184538A1
公开(公告)日：2012-07-19
申请号：US13370444
申请日：2012-02-10
IPC分类号： A61K31/541 , C07D413/14 , C07D417/14 , A61P25/28 , A61K31/444 , A61K31/501 , A61K31/4545 , A61K31/5377 , C07D413/12 , A61K31/4439
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D491/10
摘要： The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and useful for the treatment of cognitive disorders, such as Alzheimer's disease.
摘要翻译： 本发明涉及式I的异恶唑 - 吡啶衍生物，其中X，R 1至R 6如本文所述。 该化合物对GABA Aα5受体结合位点是有活性的，可用于治疗认知障碍，如阿尔茨海默病。
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公开(公告)号：US08163728B2
公开(公告)日：2012-04-24
申请号：US12768770
申请日：2010-04-28
IPC分类号： A61K31/422 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4439 , C07D417/14 , C07D413/14 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
摘要翻译： 本发明涉及式I的异恶唑 - 吡唑，对GABA Aα5受体具有亲和性和选择性，其制备方法，含有它们的药物组合物及其作为治疗剂的用途。 本发明的活性化合物可用作认知增强剂或用于治疗和/或预防性治疗认知障碍如阿尔茨海默氏病。
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130.发明授权公开(公告)号：US08001841B2
公开(公告)日：2011-08-23
申请号：US11489889
申请日：2006-07-20
申请人： Andrew Thomas
发明人： Andrew Thomas
IPC分类号： G01N29/04
CPC分类号： G01N29/44 , G01N29/043 , G01N29/262 , G01N29/42 , G01N29/4463 , G01N2291/044 , G01N2291/102 , H03M1/188
摘要： A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults.
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