公开(公告)号：US10532015B2

公开(公告)日：2020-01-14

申请号：US16225898

申请日：2018-12-19

Applicant: Colgate-Palmolive Company

Inventor： Aarti Rege ,  Michael Prencipe

IPC: A61K8/21 ,  A61K8/44 ,  A61K8/27 ,  A61K8/35 ,  A61K8/365 ,  A61K8/24 ,  A61Q11/00

Abstract: An oral care composition comprising zinc phosphate, stannous fluoride, arginine or lysine and an organic acid buffer system, as well as methods of using the same.

公开(公告)号：US10524991B2

公开(公告)日：2020-01-07

申请号：US16376185

申请日：2019-04-05

Applicant: Colgate-Palmolive Company

Inventor： Aarti Rege ,  Michael Prencipe

IPC: A61K8/21 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/20 ,  A61K8/24 ,  A61K8/362 ,  A61K8/19

Abstract: An oral care composition comprising high water oral care compositions comprising an orally acceptable carrier, zinc phosphate, a first stannous ion source (i.e., stannous fluoride), and a second stannous ion source (i.e., stannous chloride). Methods and uses for this composition are also described throughout.

公开(公告)号：US10441517B2

公开(公告)日：2019-10-15

申请号：US15106457

申请日：2014-12-10

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Michael Prencipe ,  Yun Xu ,  Xiao Yi Huang

IPC: A61K8/02 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/43 ,  A61K8/36 ,  A61K8/44

Abstract: An oral care composition comprising: (a) arginine, in free or salt form; and (b) zinc oxide and zinc citrate. The oral care composition can reduce or inhibit biofilm formation in an oral cavity.

公开(公告)号：US10335615B2

公开(公告)日：2019-07-02

申请号：US15629190

申请日：2017-06-21

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  Dandan Chen ,  Robert D'Ambrogio ,  Paul Thomson ,  Harsh Mahendra Trivedi ,  Michael Prencipe ,  James Masters ,  Stanislav Jaracz

IPC: A61K8/21 ,  A61K8/22 ,  A61K8/27 ,  A61K8/34 ,  A61K8/35 ,  A61K8/97 ,  A61K45/06 ,  A61K8/365 ,  A61Q11/00 ,  A61Q17/00 ,  A61K36/9068

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US10278906B2

公开(公告)日：2019-05-07

申请号：US15630335

申请日：2017-06-22

Applicant: Colgate-Palmolive Company

Inventor： Aarti Rege ,  Michael Prencipe ,  Madhuleena Bhadra

IPC: A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61K8/36 ,  A61Q11/00

Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same.

公开(公告)号：US20190076677A1

公开(公告)日：2019-03-14

申请号：US15768918

申请日：2015-10-22

Applicant: Colgate-Palmolive Company

Inventor： Rabab Ahmed ,  Michael Prencipe

IPC: A61Q11/00 ,  A61K31/167 ,  A61K31/245 ,  A61K8/81

Abstract: An oral care composition comprising a local anaesthetic agent, a film-forming polymer and a non-aqueous vehicle wherein the film-forming polymer comprises an alkyl vinyl ether-maleic acid or anhydride copolymer or salt thereof is provided.

公开(公告)号：US10213369B2

公开(公告)日：2019-02-26

申请号：US15948654

申请日：2018-04-09

Applicant: Colgate-Palmolive Company

Inventor： Kavita Vemishetti ,  Linh Fruge ,  Michael Prencipe

IPC: A61K8/19 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/73 ,  A61K8/81 ,  A61K8/21 ,  A61K8/24

Abstract: An oral care composition containing a stannous ion source, a zinc ion source, a polyphosphate, and a thickening agent. The thickening agent contains polyvinylpyrrolidone, a polysaccharide gum and carboxymethyl cellulose. The compositions have excellent rheology properties.

公开(公告)号：US20180221257A1

公开(公告)日：2018-08-09

申请号：US15948654

申请日：2018-04-09

Applicant: Colgate-Palmolive Company

Inventor： Kavita Vemishetti ,  Linh Fruge ,  Michael Prencipe

IPC: A61K8/19 ,  A61K8/27 ,  A61K8/81 ,  A61K8/21 ,  A61K8/24 ,  A61Q11/00 ,  A61K8/73

CPC classification number: A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8176 ,  A61Q11/00

Abstract: An oral care composition containing a stannous ion source, a zinc ion source, a polyphosphate, and a thickening agent. The thickening agent contains polyvinylpyrrolidone, a polysaccharide gum and carboxymethyl cellulose. The compositions have excellent rheology properties.

公开(公告)号：US20180168957A1

公开(公告)日：2018-06-21

申请号：US15848009

申请日：2017-12-20

Applicant: Colgate-Palmolive Company

Inventor： Aarti Rege ,  Michael Prencipe ,  Paul Thomson ,  Rehana Begum-Gafur

IPC: A61K8/24 ,  A61K8/27 ,  A61K8/21 ,  A61Q11/00

CPC classification number: A61K8/24 ,  A61K8/20 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00

Abstract: This invention relates to oral care compositions comprising zinc phosphate, a first source of stannous (e.g., stannous fluoride); and a second source of stannous, wherein the second source of stannous comprises stannous pyrophosphate, as well as to methods of using and of making these compositions.

公开(公告)号：US09968527B2

公开(公告)日：2018-05-15

申请号：US14989022

申请日：2016-01-06

Applicant: Colgate-Palmolive Company

Inventor： James R. Brown ,  Linh Fruge ,  Tao Xu ,  Michael Prencipe

IPC: A61K8/00 ,  A61K8/24 ,  A61K8/36 ,  A61Q11/00 ,  A61K8/21 ,  A61K8/03 ,  A61K8/19 ,  A61K8/20 ,  A61K8/81 ,  A61K8/55 ,  A61K8/69 ,  A61K8/25

CPC classification number: A61K8/21 ,  A61K8/03 ,  A61K8/19 ,  A61K8/20 ,  A61K8/24 ,  A61K8/25 ,  A61K8/55 ,  A61K8/69 ,  A61K8/8164 ,  A61K2800/28 ,  A61K2800/591 ,  A61Q11/00

Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions. Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.