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公开(公告)号：US10959932B2
公开(公告)日：2021-03-30
申请号：US16067014
申请日：2016-12-30
发明人： Carlo Daep , Michael Fitzgerald , Ekta Makwana , Peter R. Hilliard, Jr. , Shamim Ansari , Robert D'Ambrogio
IPC分类号： A61K8/64 , C01B33/149 , A61Q11/00 , A61K8/02 , A61K9/00 , A61K8/44 , A61K8/25 , A61K6/54 , A61K47/60 , A61K8/21 , A61K8/27 , A61K38/17 , A61K9/16
摘要： Disclosed herein is mucin-coated silica, compositions comprising the same, and methods of promoting the aggregation and/or clearance of oral bacteria using such compositions.
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公开(公告)号：US20170014322A1
公开(公告)日：2017-01-19
申请号：US15104244
申请日：2013-12-16
发明人： Robert D'Ambrogio , Andrei Potanin , Guisheng Pan , Nora Lin
CPC分类号： A61K8/36 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/34 , A61K8/345 , A61K8/731 , A61K2800/28 , A61K2800/48 , A61K2800/524 , A61K2800/592 , A61Q11/00
摘要： The present invention provides an oral care composition comprising, based on the total weight of the composition: (a) 15 to 24 weight % calcium carbonate; (b) 0.9 to 2.5 weight % cellulose ether thickening agent; (c) 7 to 10 weight % thickening silica; and (d) at least 40 weight % water.
摘要翻译： 本发明提供一种口腔护理组合物，其包含基于组合物的总重量：（a）15至24重量％的碳酸钙; （b）0.9至2.5重量％的纤维素醚增稠剂; （c）7至10重量％增稠二氧化硅; 和（d）至少40重量％的水。
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公开(公告)号：US09949907B2
公开(公告)日：2018-04-24
申请号：US15104085
申请日：2013-12-16
发明人： Robert D'Ambrogio , Andrei Potanin , Guisheng Pan , Nora Lin
CPC分类号： A61K8/36 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/345 , A61K8/73 , A61K8/731 , A61K2800/28 , A61K2800/48 , A61K2800/592 , A61Q11/00
摘要： The present invention provides an oral care composition comprising, by total weight of the composition: (a) 15 to 35 weight % calcium carbonate; (b) 0.5 to 2 weight % cellulose ether thickening agent; (c) 1 to 6 weight % clay thickening agent; and (d) at least 35 weight % water; wherein, when the composition comprises less than 28 weight % calcium carbonate and less than 4 weight % clay thickening agent, the cellulose ether thickening agent is present in an amount of greater than 1 weight %.
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公开(公告)号：US20170258691A1
公开(公告)日：2017-09-14
申请号：US15529838
申请日：2014-12-19
发明人： Robert D'Ambrogio
CPC分类号： A61K8/11 , A61K8/042 , A61K8/22 , A61K8/466 , A61K8/85 , A61K2800/43 , A61K2800/48 , A61Q11/00
摘要： Disclosed is a stable oral care composition including an orally acceptable vehicle, and a colorant encapsulated by a biodegradable polymer. Methods of preparing the stable oral care composition and using the oral care composition to promote oral health are also disclosed.
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公开(公告)号：US20170014316A1
公开(公告)日：2017-01-19
申请号：US15104507
申请日：2013-12-16
发明人： Robert D'Ambrogio , Andrei Potanin , Guisheng Pan , Nora Lin
CPC分类号： A61K8/19 , A61K8/24 , A61K8/25 , A61K8/731 , A61K2800/28 , A61K2800/524 , A61Q11/00
摘要： The present invention provides oral care compositions comprising, by total weight of the composition: (a) 15 to 35 weight % calcium carbonate; and (b) 5 to 25 weight % talc. In one aspect, the total concentration of talc and calcium carbonate in the composition is greater than 35 weight %. In another aspect where the total concentration of talc and calcium carbonate is 35 weight % or less, the composition also includes an additional structuring agent, which comprises at least one of: (i) a cellulose ether thickening agent; and (ii) an inorganic thickening agent selected from thickening silica, a clay thickening agent, and mixtures thereof.
摘要翻译： 本发明提供口腔护理组合物，其包含按组合物的总重量计：（a）15-35重量％的碳酸钙; 和（b）5至25重量％的滑石。 一方面，组合物中滑石和碳酸钙的总浓度大于35重量％。 在滑石和碳酸钙的总浓度为35重量％以下的另一方面，该组合物还包括另外的结构化剂，其包含以下至少一种：（i）纤维素醚增稠剂; 和（ii）选自增稠二氧化硅，粘土增稠剂及其混合物的无机增稠剂。
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公开(公告)号：US10773105B2
公开(公告)日：2020-09-15
申请号：US16425312
申请日：2019-05-29
发明人： Ying Yang , Dandan Chen , Robert D'Ambrogio , Paul Thomson , Harsh Mahendra Trivedi , Michael Prencipe , James Masters , Stanislav Jaracz
IPC分类号： A61Q11/00 , A61K8/34 , A61K8/35 , A61K8/365 , A61Q17/00 , A61K8/21 , A61K8/22 , A61K8/27 , A61K8/97 , A61K36/9068 , A61K45/06
摘要： This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
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公开(公告)号：US20240173220A1
公开(公告)日：2024-05-30
申请号：US18516422
申请日：2023-11-21
发明人： Diana Liceth HENAO ADLEVANKIN , Courtney Nicole Harris , Gokul Govindaraju , Robert D'Ambrogio , Jean Denis , Lauren Evans
CPC分类号： A61K8/21 , A61K8/19 , A61K8/24 , A61K8/44 , A61K8/442 , A61K8/466 , A61K8/602 , A61Q11/00 , A61K2800/30 , A61K2800/596
摘要： Described herein are oral care compositions having a surfactant system comprising four or more surfactants individually selected from a non-sulfate based anionic surfactant, an amphoteric surfactant, a nonionic surfactant, and an amino acid surfactant; a stannous ion source; a nitrate ion source; and a phosphate source. Methods of making and using these compositions are also described.
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公开(公告)号：US10335615B2
公开(公告)日：2019-07-02
申请号：US15629190
申请日：2017-06-21
发明人： Ying Yang , Dandan Chen , Robert D'Ambrogio , Paul Thomson , Harsh Mahendra Trivedi , Michael Prencipe , James Masters , Stanislav Jaracz
IPC分类号： A61K8/21 , A61K8/22 , A61K8/27 , A61K8/34 , A61K8/35 , A61K8/97 , A61K45/06 , A61K8/365 , A61Q11/00 , A61Q17/00 , A61K36/9068
摘要： This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
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公开(公告)号：US09974723B2
公开(公告)日：2018-05-22
申请号：US15104244
申请日：2013-12-16
发明人： Robert D'Ambrogio , Andrei Potanin , Guisheng Pan , Nora Lin
IPC分类号： A61Q11/00 , A61K8/25 , A61K33/10 , A61K47/38 , A61K8/36 , A61K8/73 , A61K8/19 , A61K8/24 , A61K8/34
CPC分类号： A61K8/36 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/34 , A61K8/345 , A61K8/731 , A61K2800/28 , A61K2800/48 , A61K2800/524 , A61K2800/592 , A61Q11/00
摘要： The present invention provides an oral care composition comprising, based on the total weight of the composition: (a) 15 to 24 weight % calcium carbonate; (b) 0.9 to 2.5 weight % cellulose ether thickening agent; (c) 7 to 10 weight % thickening silica; and (d) at least 40 weight % water.
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公开(公告)号：US20170014321A1
公开(公告)日：2017-01-19
申请号：US15104085
申请日：2013-12-16
发明人： Robert D'Ambrogio , Andrei Potanin , Guisheng Pan , Nora Lin
CPC分类号： A61K8/36 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/345 , A61K8/73 , A61K8/731 , A61K2800/28 , A61K2800/48 , A61K2800/592 , A61Q11/00
摘要： The present invention provides an oral care composition comprising, by total weight of the composition: (a) 15 to 35 weight % calcium carbonate; (b) 0.5 to 2 weight % cellulose ether thickening agent; (c) 1 to 6 weight % clay thickening agent; and (d) at least 35 weight % water; wherein, when the composition comprises less than 28 weight % calcium carbonate and less than 4 weight % clay thickening agent, the cellulose ether thickening agent is present in an amount of greater than 1 weight %.
摘要翻译： 本发明提供一种口腔护理组合物，其包含组合物的总重量：（a）15至35重量％的碳酸钙; （b）0.5〜2重量％纤维素醚增稠剂; （c）1〜6重量％粘土增稠剂; 和（d）至少35重量％的水; 其中当所述组合物包含小于28重量％的碳酸钙和小于4重量％的粘土增稠剂时，纤维素醚增稠剂的存在量大于1重量％。
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