公开(公告)号：US20230129902A1

公开(公告)日：2023-04-27

申请号：US17971238

申请日：2022-10-21

Applicant: Dexcom, Inc.

Inventor： Jee Hye Park ,  Spencer Troy Frank ,  David A. Price ,  Kazanna C. Hames ,  Charles R. Stroyeck ,  Joseph J. Baker ,  Arunachalam Panch Santhanam ,  Peter C. Simpson ,  Abdulrahman Jbaily ,  Justin Yi-Kai Lee ,  Qi An

IPC: G16H50/30 ,  G06N20/00

Abstract: Disease prediction using analyte measurements and machine learning is described. In one or more implementations, a combination of features of analyte measurements may be selected from a plurality of features of the analyte measurements based on a robustness metric and a performance metric of the combination, and a machine learning model may be trained to predict a health condition classification using the combination. The performance metric may be associated with an accuracy of predicting the health condition classification, and the robustness metric may be associated with an insensitivity to analyte sensor manufacturing variabilities on the accuracy. Once trained, the machine learning model predicts the health condition classification for a user based on analyte measurements of the user collected by a wearable analyte monitoring device. The combination of features may be extracted from the analyte measurements of the user and input into the machine learning model to predict the classification.

公开(公告)号：US20230014091A1

公开(公告)日：2023-01-19

申请号：US17945928

申请日：2022-09-15

Applicant: DexCom, Inc.

Inventor： Joseph J. Baker ,  Philip Thomas Pupa ,  Timothy Joseph Goldsmith ,  Jonathan Bodnar ,  Jason Halac ,  John Michael Gray ,  Neal Davis Johnston ,  Justen Deering England ,  Peter C. Simpson ,  Paul V. Neale ,  Jennifer Blackwell ,  Maria Noel Brown Wells ,  Kenneth Pirondini ,  Andrew Michael Reinhardt ,  Mark Douglas Kempkey ,  Young Woo Lee ,  Warren Terry ,  Patrick John Castagna ,  David A. Keller ,  Randall Scott Koplin ,  Andrew Joncich ,  Nirav Bhatt

IPC: A61B5/145 ,  A61B5/00 ,  A61B17/34

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

公开(公告)号：US20220400991A1

公开(公告)日：2022-12-22

申请号：US17892707

申请日：2022-08-22

Applicant: DexCom, Inc.

Inventor： Jason M. HALAC ,  John Michael Gray ,  Neal Davis Johnston ,  Justen Deering England ,  Peter C. Simpson ,  Paul V. Neale ,  Jennifer Blackwell ,  Maria Noel Brown Wells ,  Kenneth Pirondini ,  Andrew Michael Reinhardt ,  Mark Douglas Kempkey

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

公开(公告)号：US11504004B2

公开(公告)日：2022-11-22

申请号：US16783107

申请日：2020-02-05

Applicant: DexCom, Inc.

Inventor： Arturo Garcia ,  Peter C. Simpson ,  Apurv Ullas Kamath ,  Naresh C. Bhavaraju ,  Stephen J. Vanslyke

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/11

Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.

公开(公告)号：US20220322977A1

公开(公告)日：2022-10-13

申请号：US17849532

申请日：2022-06-24

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  C12Q1/00

Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US11452466B2

公开(公告)日：2022-09-27

申请号：US16011527

申请日：2018-06-18

Applicant: DexCom, Inc.

Inventor： Joseph J. Baker ,  Philip Thomas Pupa ,  Timothy Joseph Goldsmith ,  Jonathan Bodnar ,  Jason Halac ,  John Michael Gray ,  Neal Davis Johnston ,  Justen Deering England ,  Peter C. Simpson ,  Paul V. Neale ,  Jennifer Blackwell ,  Maria Noel Brown Wells ,  Kenneth Pirondini ,  Andrew Michael Reinhardt ,  Mark Douglas Kempkey ,  Young Woo Lee ,  Warren Terry ,  Patrick John Castagna ,  David A. Keller ,  Randall Scott Koplin ,  Andrew Joncich ,  Nirav Bhatt

IPC: A61B5/145 ,  A61B5/00 ,  A61B17/34

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

公开(公告)号：US11412966B2

公开(公告)日：2022-08-16

申请号：US17446280

申请日：2021-08-27

Applicant: DexCom, Inc.

Inventor： Jason Halac ,  John Michael Gray ,  Neal Davis Johnston ,  Justen Deering England ,  Peter C. Simpson ,  Paul V. Neale ,  Jennifer Blackwell ,  Maria Noel Brown Wells ,  Kenneth Pirondini ,  Andrew Michael Reinhardt ,  Mark Douglas Kempkey

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1468 ,  A61B5/00

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

公开(公告)号：US20220202318A1

公开(公告)日：2022-06-30

申请号：US17696582

申请日：2022-03-16

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Sebastian Böhm ,  David DeRenzy ,  Jason Halac ,  Daniel S. Kline ,  Phong Lieu ,  Adam J. Livingston ,  Steve Masterson ,  Paul V. Neale ,  Peter C. Simpson ,  Antonio Joao Ubach

IPC: A61B5/145 ,  A61B5/00

Abstract: The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator.

公开(公告)号：US20220183718A1

公开(公告)日：2022-06-16

申请号：US17583128

申请日：2022-01-24

Applicant: DexCom, Inc.

Inventor： Neel Shah ,  Jennifer Blackwell ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Shanger Wang

IPC: A61B17/34 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/32

Abstract: The present disclosure relates to a needle including a wall structure, a cutting edge and a blunt contour. The needle advantageously can be used to deliver a sensor (such as a glucose or other analyte sensor) through an outer skin layer and into a sensor depth in a less invasive way than prior art needles. The size of the cutting edge is balanced against a portion of the distal wall structure that has blunt contours. Thus, the needle is capable of cutting the more durable outer skin layer (first phase) and then progressively stretching open the cut for further advancement into the subcutaneous layer (second phase). When the needle is sufficiently advanced, it is retracted leaving the sensor in a desired position. Early testing has shown a reduction of “dip and recover” from glucose sensors delivered using the needle.

公开(公告)号：US20220111148A1

公开(公告)日：2022-04-14

申请号：US17556761

申请日：2021-12-20

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC: A61M5/315 ,  A61B5/1486 ,  A61M15/00 ,  A61M11/00 ,  A61B5/00 ,  A61B5/145 ,  A61M5/172 ,  G16H40/63 ,  G16H10/40 ,  G16H20/17

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.