公开(公告)号：US20050013833A1

公开(公告)日：2005-01-20

申请号：US10484000

申请日：2002-07-18

Applicant: Jean-Thierry Simonnet

Inventor： Jean-Thierry Simonnet

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/40 ,  A61K8/49 ,  A61K8/97 ,  A61K9/127 ,  A61K9/133 ,  A61Q19/00 ,  A61Q19/08 ,  A61K35/78 ,  A61K9/14 ,  A61K31/57

CPC classification number: A61K9/1272

Abstract: The present invention relates to a composition comprising: a dispersion, in an outer aqueous phase, of vesicles formed by lipid lamellar phases comprising at least one amphiphilic lipid and encapsulating an inner hydrophilic phase, the said lamellar phases not comprising succinic and/or hemisuccinic derivatives, and at least one DHEA-based compound included in the said lamellar phases. The incorporation of the DHEA-based compound into the lamellar phases of vesicles makes it possible to avoid its recrystallization in the outer aqueous phase and to improve its bioavailability.

Abstract translation: 本发明涉及一种组合物，其包含：在外部水相中的分散体，由包含至少一种两亲性脂质和包封内部亲水相的脂质层状相形成的囊泡，所述层状相不包含琥珀酸和/或半琥珀酸衍生物 ，以及包含在所述层状相中的至少一种基于DHEA的化合物。 将DHEA基化合物掺入囊泡的层状相使得可以避免其在外部水相中的再结晶并提高其生物利用度。

公开(公告)号：US06689371B1

公开(公告)日：2004-02-10

申请号：US09460092

申请日：1999-12-13

Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

IPC: A61K600

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/062 ,  A61K8/60 ,  A61K8/602 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/938

Abstract: A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract translation: 纳米乳液的数均粒径小于100nm的纳米乳液包含在小于或等于45℃的温度下为固体的表面活性剂，该表面活性剂选自脂肪酸的酯 以及脂肪醇和糖的糖和醚，以及至少一种分子量大于400的油，油相量与表面活性剂的重量比为2至10。 纳米乳液可以用于化妆品和皮肤病学应用，特别是用于保湿皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。

公开(公告)号：US06419946B1

公开(公告)日：2002-07-16

申请号：US09459581

申请日：1999-12-13

Applicant: Odile Sonneville ,  Jean-Thierry Simonnet ,  Sylvie Legret

Inventor： Odile Sonneville ,  Jean-Thierry Simonnet ,  Sylvie Legret

IPC: A61F200

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/938

Abstract: A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm, comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract translation: 纳米乳液，其数均粒径小于100nm的纳米乳液包含选自脂肪酸或脂肪醇的混合酯，羧酸和甘油的表面活性剂和至少一种含有 分子量大于400，油相量与表面活性剂的重量比为2至10.纳米乳液可用于例如化妆品和皮肤病学领域，特别是用于保湿 皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。

公开(公告)号：US6066328A

公开(公告)日：2000-05-23

申请号：US185502

申请日：1998-11-04

Applicant: Alain Ribier ,  Jean-Thierry Simonnet ,  Jacques Michelet

Inventor： Alain Ribier ,  Jean-Thierry Simonnet ,  Jacques Michelet

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/29 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/60 ,  A61K8/66 ,  A61K8/73 ,  A61K8/92 ,  A61K8/97 ,  A61K9/127 ,  A61P17/08 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A51K7/48

CPC classification number: A61Q19/00 ,  A61K8/0295 ,  A61K8/062 ,  A61K8/608 ,  A61K9/1274 ,  B82Y5/00 ,  A61K2800/21 ,  A61Q17/04 ,  A61Q19/08 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/942 ,  Y10S514/943

Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.

Abstract translation: 本发明涉及一种化妆品或皮肤病学组合物，其包含由油状球形成的水包油型乳液，每一种乳状液体均设置有层状液晶涂层并分散在水相中。 含有至少一种化学或皮肤病学活性的亲脂性化合物的每个油状球体分别用至少一种亲脂性表面活性剂和至少一种离子性表面活性剂从至少一种亲脂性表面活性剂获得的单层或多层膜单独涂覆 两性脂质赋予乳液pH为5.5至7.5，涂覆的油状球体的平均直径小于500纳米。

公开(公告)号：US5679374A

公开(公告)日：1997-10-21

申请号：US367422

申请日：1994-12-30

Applicant: Chantal Fanchon ,  Alain Ribier ,  Jean-Thierry Simonnet ,  Evelyne Segot

Inventor： Chantal Fanchon ,  Alain Ribier ,  Jean-Thierry Simonnet ,  Evelyne Segot

IPC: A61K8/04 ,  A61K8/00 ,  A61K8/14 ,  A61K8/19 ,  A61K8/27 ,  A61K8/30 ,  A61K8/34 ,  A61K8/36 ,  A61K8/368 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K8/60 ,  A61K8/63 ,  A61K8/67 ,  A61K8/85 ,  A61K8/86 ,  A61K8/92 ,  A61K9/127 ,  A61K9/133 ,  A61K31/575 ,  A61K45/00 ,  A61P17/12 ,  A61P17/18 ,  A61P29/00 ,  A61P31/04 ,  A61Q17/00 ,  A61Q19/00 ,  A61K7/00

CPC classification number: A61K8/368 ,  A61K8/14 ,  A61K8/347 ,  A61K8/671 ,  A61K9/127 ,  A61Q19/00 ,  Y10S514/846 ,  Y10S514/859

Abstract: Compositions which comprise a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from antimicrobial agents, antiseptic agents, antibiotics, anti-inflammatory agents, anti-seborrhoeic agents, retinol and the derivatives thereof, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from keratolytic agents, protective agents, moisturizing agents and antioxidants, for treating these surface layers, are particularly effective for the treatment of acne.

Abstract translation: 组合物，其包含脂质囊泡的第一分散体，其能够渗入皮肤深层并且含有至少一种活性剂，其选自抗微生物剂，防腐剂，抗生素，抗炎剂，抗脂溢剂，视黄醇 以及其衍生物，用于处理这些深层，以及能够渗入皮肤表层的脂质囊泡的第二分散体，并且含有至少一种选自角质分解剂，保护剂，保湿剂和抗氧化剂的活性剂 用于处理这些表面层对治疗痤疮特别有效。