公开(公告)号：US20230357241A1

公开(公告)日：2023-11-09

申请号：US18246247

申请日：2021-09-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Xiawei WEI ,  Chundao YANG ,  Guanghai XU ,  Ning JIANG ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00

摘要： A series of 1H-pyrrolo[2,3-c]pyridine compounds and an application thereof are provided. The compounds include those represented by formula (P) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230257398A1

公开(公告)日：2023-08-17

申请号：US17922336

申请日：2021-04-29

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Guoli ZHANG ,  Shaolong LI ,  Weizhi GE ,  Shuhui CHEN

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： The present invention relates to a pyrimidine-based tricyclic compound and a use thereof, and specifically, relates to a pyrimidine-based tricyclic compound and a use thereof in preparation of a drug for treating a related disease. Specifically, disclosed are a compound represented by formula (II), a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230242507A1

公开(公告)日：2023-08-03

申请号：US18002476

申请日：2021-06-28

申请人： MEDSHINE DISCOVERY INC.

发明人： Ke AN ,  Na GAO ,  Guoping HU ,  Jian LI ,  Shuhui CHEN ,  Deheng SUN

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D491/044 ,  C07D403/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D491/044 ,  C07D403/14 ,  A61P35/00

摘要： A novel indazole compound, a preparation method therefor, and use thereof in the preparation of drugs for treating related diseases. Specifically disclosed are a compound of formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230220386A1

公开(公告)日：2023-07-13

申请号：US17781876

申请日：2020-12-04

申请人： MEDSHINE DISCOVERY INC.

发明人： Ke AN ,  Fei SUN ,  Charles Z. DING ,  Jian LI ,  Shuhui CHEN

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K31/713

摘要： Provided is an application of a ribavirin derivative as an oligonucleotide embedded group. Specifically, disclosed is an application of r as a siRNA embedded group. Also provided is an r′-embedded siRNA conjugate, a double-stranded siRNA conjugate, a salt thereof, and an application thereof. The r′-embedded siRNA conjugate and the salt thereof can effectively reduce the S antigen content and E antigen content of the hepatitis B virus, providing an effective, feasible approach for the functional cure of chronic hepatitis B.

公开(公告)号：US20230219902A1

公开(公告)日：2023-07-13

申请号：US18000939

申请日：2021-06-10

申请人： MEDSHINE DISCOVERY INC.

发明人： Jianfei WANG ,  Yang ZHANG ,  Shuhui CHEN

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： Disclosed is a method for preparing a chlorinated compound, and specifically disclosed is a method for preparing a compound represented by formula (I).

公开(公告)号：US20230167098A1

公开(公告)日：2023-06-01

申请号：US17905538

申请日：2021-03-04

申请人： MEDSHINE DISCOVERY INC.

发明人： Guanglong SUN ,  Chunli SHEN ,  Chengde WU ,  Shuhui CHEN

IPC分类号： C07D405/14 ,  C07D401/14

CPC分类号： C07D405/14 ,  C07D401/14

摘要： The present application relates to the field of medicine. Specifically, disclosed are a compound of formula (I), a preparation method therefor, and a pharmaceutical composition comprising the compound.

公开(公告)号：US20230141887A1

公开(公告)日：2023-05-11

申请号：US17907607

申请日：2021-03-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Xiangyu FU ,  Charles Z. DING ,  Lihong HU ,  Xu ZENG ,  Ting YAO

IPC分类号： C07D471/10

CPC分类号： C07D471/10 ,  C07B2200/13

摘要： Disclosed are a salt type and a crystal form (I) of a diazaspiropyran compound, and a preparation method therefor. Also disclosed is the use of the salt type and the crystal form in the preparation of drugs for treating related diseases.

公开(公告)号：US20230070611A1

公开(公告)日：2023-03-09

申请号：US17781815

申请日：2020-12-04

申请人： ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Juan YU ,  Zhiliang CHEN ,  Shicong WANG ,  Tingting YIN ,  Kaili JIAN ,  Xiaoping ZHENG ,  Zhigan JIANG ,  Haiying HE

IPC分类号： C07D495/04

摘要： Disclosed are a crystal form of a thieno[2,3-c]pyridazine-4(1H)-one compound, a preparation method therefor and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2.

公开(公告)号：US20230026616A1

公开(公告)日：2023-01-26

申请号：US17779322

申请日：2020-11-25

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Shanghua XIA ,  Zhaoguo CHEN ,  Zuhao GUO ,  Yanxin YU ,  Kai ZHOU ,  Boyu HU ,  Li ZHANG ,  Fen JIANG ,  Jingjing WANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P35/00 ,  A61K45/06

摘要： A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.

公开(公告)号：US20220372036A1

公开(公告)日：2022-11-24

申请号：US17621621

申请日：2020-06-24

申请人： Medshine Discovery Inc. ,  Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： Charles Z. Ding ,  Shuhui Chen

IPC分类号： C07D471/22 ,  C07D498/22

摘要： A class of KRAS G12C mutant protein inhibitors, specifically disclosing the compound shown in formula (I), and an isomer and a pharmaceutically acceptable salt thereof.