公开(公告)号：US20110004218A1

公开(公告)日：2011-01-06

申请号：US12816624

申请日：2010-06-16

申请人： Joël DRAI ,  Josette GUILLOT

发明人： Joël DRAI ,  Josette GUILLOT

IPC分类号： A61B17/56 ,  A61K35/56 ,  A61K9/14 ,  A61P19/08

CPC分类号： A61L27/3691 ,  A61K35/618 ,  A61L27/28 ,  A61L27/3604 ,  A61L27/365 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/40

摘要： The present invention relates to a method for the preparation of mechano-structured nacre by mechanosynthesis of micrometric nacre powder, characterized in that the temperature of the nacre is kept below 40° C. It also relates to the mechano-structured nacre and to uses thereof, in particular on implants and bone substitute pieces on which the mechano-structured nacre is deposited.

摘要翻译： 本发明涉及一种通过微米珍珠粉的机械合成制备机械结构珍珠质的方法，其特征在于，珍珠母的温度保持在40℃以下。它还涉及机械结构珍珠质及其用途 ，特别是在其上沉积机械结构珍珠质的植入物和骨代用品上。

公开(公告)号：US20100330205A1

公开(公告)日：2010-12-30

申请号：US12735557

申请日：2008-01-29

申请人： Toshio Nakamori

发明人： Toshio Nakamori

IPC分类号： A61K33/10 ,  A61P11/00

CPC分类号： A61K36/9066 ,  A61K33/00 ,  A61K35/618 ,  A61K36/00 ,  A61K36/185 ,  A61K36/234 ,  A61K36/235 ,  A61K36/258 ,  A61K36/28 ,  A61K36/346 ,  A61K36/539 ,  A61K36/575 ,  A61K36/58 ,  A61K36/708 ,  A61K36/752 ,  A61K36/756 ,  A61K36/8905 ,  Y02A50/473 ,  A61K2300/00

摘要： A pharmaceutical composition comprising 1.5 parts by weight powdered fennel, 2.0 parts by weight powdered rhubarb, 1.0 part by weight powdered glycyrrhiza, 2.0 parts by weight powdered phellodendron bark, 1.0 part by weight powdered zedoary, 1.5 parts by weight powdered picrasma wood, 1.0 part by weight powdered matricaria chamomilla, 1.5 parts by weight powdered geranium herb, 1.0 part by weight powdered ginseng, 1.5 parts by weight powdered citrus unshiu peel, 1.0 part by weight powdered scutellaria root, 1.0 part by weight powdered magnolia bark, 2.0 parts by weight powdered oyster shell, 1.0 part by weight powdered cyperus rhizome, 2.0 parts by weight powdered platycodon root, 2.0 parts by weight powdered melia azedarach, 1.0 part by weight powdered cnidium rhizome, 2.0 parts by weight sodium bicarbonate and 4.0 parts by weight precipitated calcium carbonate in 30 parts by weight of the composition.

摘要翻译： 一种药物组合物，其包含1.5重量份粉末茴香，2.0重量份粉末大黄，1.0重量份粉状甘草，2.0重量份粉状黄柏树皮，1.0重量份粉末状粉末，1.5重量份粉状斑马木，1.0份 粉末状麦麸，1.5重量份粉末天竺葵草本，1.0重量份人参粉末，1.5重量份粉状柑橘皮，1.0重量份粉末黄芩根，1.0重量份粉状木兰树皮，2.0重量份 粉状牡蛎壳，1.0重量份粉状香草根茎，2.0重量份粉状桔梗根，2.0重量份粉状楝树粉，1.0重量份粉状芫荽，2.0重量份碳酸氢钠和4.0重量份沉淀碳酸钙 在30重量份的组合物中。

公开(公告)号：US20100297254A1

公开(公告)日：2010-11-25

申请号：US12812482

申请日：2008-12-12

申请人： Dan Bright

发明人： Dan Bright

IPC分类号： A61K35/56 ,  A61K36/00 ,  A61K35/60 ,  A61P19/04 ,  C12N5/02

CPC分类号： A61K36/14 ,  A61K31/202 ,  A61K35/60 ,  A61K35/618 ,  A61K2300/00

摘要： A method of treatment for cartilage degradation in an organism, which includes administering to an organism a composition including a therapeutic amount of an extract from the plant Biota orientalis. Several key components of the extract of Biota orientalis have been identified that have also been shown to have an effect in dramatically reducing and reversing cartilage degradation.

摘要翻译： 一种治疗生物体软骨降解的方法，其包括向生物体施用包含治疗量的来自植物生物群的提取物的组合物。 已经鉴定出已经显示出显着减少和逆转软骨降解的作用，已经鉴定出生物群落提取物的几个关键组分。

公开(公告)号：US20100233111A1

公开(公告)日：2010-09-16

申请号：US12643751

申请日：2009-12-21

申请人： William Wang ,  Jun Yi ,  Sheng Ke ,  Maria Halmela

发明人： William Wang ,  Jun Yi ,  Sheng Ke ,  Maria Halmela

IPC分类号： A61K8/18 ,  A61K31/715 ,  A61K38/43 ,  A61K38/46 ,  A61Q19/02 ,  A61K36/54 ,  A61K36/752 ,  A61K36/00

CPC分类号： A61K35/618 ,  A61K8/73 ,  A61K8/987 ,  A61K31/01 ,  A61K31/728 ,  A61K36/02 ,  A61K36/28 ,  A61K36/484 ,  A61K38/1825 ,  A61K38/4886 ,  A61Q19/08 ,  A61K2300/00

摘要： The present technology generally relates to skin care compositions, cosmeceuticals or formulations and methods of making or using the same. More specifically, the presently described technology generally relates to methods of making and using compositions, cosmeceuticals or formulations including a unique composition collected and refine from a gastropod, namely Helix Aspersa Müller, among others.

摘要翻译： 本技术通常涉及皮肤护理组合物，药妆品或其制备或使用方法。 更具体地，目前描述的技术通常涉及制备和使用组合物，药妆品或制剂的方法，其包括从腹足动物，即Helix AspersaMüller等收集和精制的独特组合物。

公开(公告)号：US07387797B2

公开(公告)日：2008-06-17

申请号：US10239345

申请日：2001-03-22

申请人： Peter D. Collin ,  Thomas E. Adrian

发明人： Peter D. Collin ,  Thomas E. Adrian

IPC分类号： A61K35/56 ,  A61K9/14

CPC分类号： A61K35/618

摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.

摘要翻译： 公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。 还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。 还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

公开(公告)号：US20070140988A1

公开(公告)日：2007-06-21

申请号：US10575826

申请日：2004-10-13

申请人： Nobuji Koyama ,  Shinichi Okuda ,  Koji Sasaya ,  Tomonaga Yoshida

发明人： Nobuji Koyama ,  Shinichi Okuda ,  Koji Sasaya ,  Tomonaga Yoshida

IPC分类号： A61K8/96 ,  A61K35/56

CPC分类号： A61K33/10 ,  A61K9/0063 ,  A61K35/618

摘要： A therapeutic agent for periodontal diseases is provided which is prepared by utilizing a scallop shell material and which has antimicrobial activity against periodontal disease-inducing bacteria, promotes the regeneration of the alveolar bone and enables adequate prevention and treatment of periodontal diseases. The therapeutic agent for periodontal diseases is obtained from an aqueous solution prepared by dissolving, in water, a mixture of a calcium carbonate powder prepared by subjecting shells having a crystal structure comprising a calcite type structure of calcium carbonate to grinding and primary firing, and a calcium oxide powder prepared by subjecting the calcium carbonate powder to firing at a temperature higher than the primary firing temperature.

摘要翻译： 提供了通过利用扇贝壳材料制备牙周病的治疗剂，其具有抗牙周病诱导细菌的抗微生物活性，促进牙槽骨的再生，并能够充分预防和治疗牙周病。 牙周病治疗剂是从水溶液中制备的水溶液得到的，所述水溶液通过将通过将具有包含方解石型结构的碳酸钙的晶体结构的壳制成的碳酸钙粉末与研磨和初次烧制而成的水溶液， 通过使碳酸钙粉末在比初级烧成温度高的温度下进行烧成而制备的氧化钙粉末。

公开(公告)号：US20070128293A1

公开(公告)日：2007-06-07

申请号：US10587968

申请日：2005-02-14

申请人： Evelyne Lopez ,  Xavier Bourrat ,  Marthe Rousseau

发明人： Evelyne Lopez ,  Xavier Bourrat ,  Marthe Rousseau

IPC分类号： A61K35/56 ,  A22C29/04

CPC分类号： A61K35/618

摘要： The invention relates to a fluid preparation method comprising the recovery of the fluid that is located between the shell and the body of a mollusc. The invention also relates to the liquid obtained using said method, and to the use thereof in the pharmaceutical field, in particular in order to improve cutaneous healing, to regenerate tissues or to promote osteogenesis or bone mineralization. The invention further relates to compositions, particularly pharmaceutical compositions, medical devices or food supplements containing same.

摘要翻译： 本发明涉及一种流体制备方法，其包括回收位于壳体和软体动物体内的流体。 本发明还涉及使用所述方法获得的液体及其在制药领域中的应用，特别是为了改善皮肤愈合，再生组织或促进成骨或骨矿化。 本发明还涉及包含其的组合物，特别是药物组合物，医疗装置或食品补充剂。

公开(公告)号：US20060110465A1

公开(公告)日：2006-05-25

申请号：US11301553

申请日：2005-12-13

申请人： Syed Hashmi ,  Wayne Leech ,  Donald McLaren ,  Keith McSporran

发明人： Syed Hashmi ,  Wayne Leech ,  Donald McLaren ,  Keith McSporran

IPC分类号： A61K35/56 ,  A61K35/34 ,  A61K36/13 ,  A61K31/728

CPC分类号： A61K35/60 ,  A61K35/618 ,  A61K36/15 ,  A61K2300/00

摘要： Compositions for primarily addressing degenerative complaints, in particular joint related conditions such as arthritis and rheumatism, in which there may also be associated inflammation, are provided. Other potential uses are also discussed, as well as prophylactic and curative applications. Preferred embodiments incorporate green-lip mussel products (particularly GLME) with shark cartilage or chondroitin compounds, and plant and bark based antioxidants are employed in a number of embodiments.

摘要翻译： 提供了主要解决退行性疾病的组合物，特别是关节炎和风湿病等联合相关病症，其中也可能伴有炎症。 还讨论了其他潜在用途，以及预防和治疗应用。 优选的实施方案包括具有鲨鱼软骨或软骨素化合物的绿唇贻贝产品（特别是GLME），并且在许多实施方案中采用植物和树皮基抗氧化剂。

公开(公告)号：US20060039992A1

公开(公告)日：2006-02-23

申请号：US11141995

申请日：2005-06-01

申请人： Bruce Miller ,  Olav Sandnes ,  John Ryan

发明人： Bruce Miller ,  Olav Sandnes ,  John Ryan

IPC分类号： A61K35/56 ,  A61K31/202

CPC分类号： A61K35/618 ,  A61K31/202 ,  A61K2300/00

摘要： Disclosed herein are compositions containing synergistic combinations of marine mollusk tissue and at least one fatty acid configured into a delivery formulation suitable for administration to humans and animals. A preferred embodiment of the compositions of the present invention may utilize an extract of green-lipped mussel and at least one polyunsaturated fatty acid selected from eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), eicosatetraenoic acid (ETA), docosapentaenoic acid (DPA), and combinations thereof, and a delivery formulation selected from tablets, capsules, liquids, oils, suspensions, emulsions, solutions, and powders. Also disclosed herein are methods for ameliorating and/or mitigating inflammatory-mediated conditions. A preferred embodiment of the methods of the present invention may include: (1) selecting a marine mollusk extract known to reduce inflammation; (2) selecting at least one fatty acid known to reduce inflammation; (3) incorporating an effective amount of marine mollusk extract and polyunsaturated fatty acid into a suitable delivery formulation; and (4) administering a delivery formulation to humans and animals to ameliorate an inflammation-mediated disorder.

摘要翻译： 本文公开了含有海洋软体动物组织和至少一种脂肪酸的协同组合的组合物，其配置成适于施用于人和动物的递送制剂。 本发明组合物的优选实施方案可利用绿唇贻贝和至少一种选自二十碳五烯酸（EPA），二十二碳六烯酸（DHA），二十碳四烯酸（ETA），二十二碳五烯酸（DPA） ）及其组合，以及选自片剂，胶囊，液体，油，悬浮液，乳剂，溶液和粉末的递送制剂。 本文还公开了用于改善和/或减轻炎症介导的病症的方法。 本发明方法的优选实施方案可包括：（1）选择已知可减少炎症的海洋软体动物提取物; （2）选择已知减少炎症的至少一种脂肪酸; （3）将有效量的海洋软体动物提取物和多不饱和脂肪酸掺入合适的递送制剂中; 和（4）向人和动物施用递送制剂以改善炎症介导的病症。

公开(公告)号：US06936280B1

公开(公告)日：2005-08-30

申请号：US10089982

申请日：2000-10-05

申请人： Evelyne Lopez ,  Alfred Edouard Chemouni

发明人： Evelyne Lopez ,  Alfred Edouard Chemouni

IPC分类号： A61K8/19 ,  A61K8/00 ,  A61K8/20 ,  A61K8/23 ,  A61K8/65 ,  A61K8/73 ,  A61K8/96 ,  A61K8/98 ,  A61K9/14 ,  A61K31/74 ,  A61K33/04 ,  A61K33/06 ,  A61K33/10 ,  A61K33/14 ,  A61K33/30 ,  A61K35/56 ,  A61K35/618 ,  A61K47/00 ,  A61P17/00 ,  A61Q19/00 ,  A01N25/00

CPC分类号： A61K8/735 ,  A61K8/65 ,  A61K8/987 ,  A61K35/618 ,  A61K2800/412 ,  A61K2800/436 ,  A61Q19/00 ,  Y10S514/951

摘要： A method for preparing a composition, comprising a) reducing mother-of-pearl into powder with grain size distribution ranging between about 1 and about 300 μm; b) placing the obtained powder in close contact with an extracting agent in the form of a hydroglycol solution of at least a collagen, of at least a proteoglycan or a mixture thereof; then c) in collecting the extraction mixture, formed by the close contact, constituting the desired composition. The composition obtainable by said method has very interesting properties relative to the skin and/or skin appendages, in particular tissue-regenerating properties, enabling for instance improved wound healing, and anti-ageing properties for preventing and/or visibly reducing effects related to skin and/or skin appendage ageing.

摘要翻译： 一种制备组合物的方法，包括a）将珍珠母变成粉末，其粒度分布范围在约1至约300μm之间; b）将获得的粉末以至少一种胶原蛋白，至少一种蛋白聚糖或其混合物的水溶液形式的萃取剂紧密接触; 然后c）收集由紧密接触形成的提取混合物，构成所需组成。 通过所述方法可获得的组合物相对于皮肤和/或皮肤附件，特别是组织再生性质具有非常有趣的性质，例如改善伤口愈合，以及用于预防和/或显着降低与皮肤相关的作用的抗老化性质 和/或皮肤附着物老化。