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131.发明授权公开(公告)号：US12123961B2
公开(公告)日：2024-10-22
申请号：US17659200
申请日：2022-04-14
发明人： Li-ta Hsu , Weisong Wen
IPC分类号： G01S19/44 , G01S17/93 , G01S17/931 , G01S19/45
CPC分类号： G01S19/44 , G01S17/931 , G01S19/45
摘要： A method for supporting positioning of a vehicle using a satellite positioning system is disclosed. The method includes generating, in real-time, a sliding window map (SWM) based on 3D point clouds from a 3D LiDAR sensor and an attitude and heading reference system (AHRS), wherein the SWM provides an environment description for detecting and correcting a non-line-of-sight (NLOS) reception; accumulating the 3D point clouds from previous frames into the SWM for enhancing a field of view (FOV) of the 3D LiDAR sensor; receiving global navigation satellite system (GNSS) measurements from satellites, by a GNSS receiver; detecting NLOS reception from the GNSS measurements using the SWM; correcting the NLOS reception by NLOS remodeling when a reflection point is not found in the SWM; and estimating a GNSS positioning by a least-squares algorithm. It is the objective to provide a method that mitigates NLOS caused by both static buildings and dynamic objects.
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132.发明公开公开(公告)号：US20240342149A1
公开(公告)日：2024-10-17
申请号：US18332751
申请日：2023-06-12
发明人： Chuen LAM , Ying Hon SZE , Yan Yin TSE
IPC分类号： A61K31/4439 , A61P27/10
CPC分类号： A61K31/4439 , A61P27/10
摘要： A pharmacologic treatment of refractive disorders, specifically myopia or hyperopia, by targeting the PPAR signaling pathway using a PPARγ agonist without any binding to PPARα. It is demonstrated that the PPARγ agonist modulates ocular growth through therapeutic intervention at the protein level of the PPAR signaling pathway. The effectiveness of the PPARγ agonist in regulating the PPAR signaling pathway and its associated proteins, as evidenced by experiments using a lens-induced myopia (LIM) animal model. More particularly, it is also demonstrated that the pharmacological reduction of myopic eye growth in terms of biometrics with dosage effect through the administration of the PPARγ agonist.
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公开(公告)号：US20240335301A1
公开(公告)日：2024-10-10
申请号：US18132011
申请日：2023-04-07
CPC分类号： A61F2/64 , A61F2/6607 , A61F2/70
摘要： A combined testbench type and walking type compliant exoskeleton system quickly and efficiently converts from a fixed testbench configuration to a mobile orthosis configuration. The addition of a series elastic actuator allows the combined testbench type and walking type compliant exoskeleton system to have a higher level of safe physical human-robot interaction and safety for users with spasticity or tremor. Alternate embodiments incorporating a combination of the rigid and compliant joints, allowing the combination of a swing test and enhancement of a user's strength for walking or other movement is also disclosed.
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公开(公告)号：US20240285586A1
公开(公告)日：2024-08-29
申请号：US18568898
申请日：2021-06-11
发明人： Sheng CHEN , Wai Chi Edward CHAN , Chen XU , Miaomiao WANG
IPC分类号： A61K31/4174 , A61K45/06 , A61P31/04
CPC分类号： A61K31/4174 , A61K45/06 , A61P31/04
摘要： Provided herein are methods and compositions useful for treating bacterial cell populations including bacterial persister cells and/or antibiotic resistant bacterial cells.
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135.发明公开公开(公告)号：US20240260848A1
公开(公告)日：2024-08-08
申请号：US18163913
申请日：2023-02-03
发明人： Jing CAI , Haonan XIAO , Tian LI
CPC分类号： A61B5/055 , G06T7/0012 , G06T2207/10088 , G06T2207/20081
摘要： A computer-implemented method for training a convolutional neural network (CNN) using training data comprising a pair of original and downsampled 4D magnetic resonance imaging (MRI) data is provided. The CNN is used to generate multi-parametric 4D magnetic resonance (MR) images based on multi-parametric 3D MR images in real-time. The method includes receiving a 4D MR image formed by a plurality of fixed images of different frames; converting the plurality of fixed images into a plurality of k-space data by non-uniform fast Fourier transform (NUFFT); applying radial scan to the k-space data to simulate real-time MR image acquisition, and generating a plurality of downsampled fixed images by inverse NUFFT; training a CNN with training data comprising the 4D MR image and the corresponding downsampled 4D MR image; and estimating the multi-parametric 4D MR image in real-time by applying apply the predicted DVF to the multi-parametric 3D MR images.
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公开(公告)号：US12037361B2
公开(公告)日：2024-07-16
申请号：US17823527
申请日：2022-08-31
IPC分类号： A61K38/00 , A61K9/00 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/16 , C07K14/00
CPC分类号： C07K14/00 , A61K9/0019 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/16 , C07K2317/76 , C07K2319/01 , C07K2319/10
摘要： The present disclosure provides methods and composition for treating multi-drug resistant cancers, in particular, breast cancers, via administration to a subject the composition including a peptide having a sequence complementary to a highly conserved motif present in substantially all integrins responsible for an integrin-mediated attachment-independent chemoresistance to one or more chemotherapeutic agents. The binding of the sequence of the peptide to the highly conserved motif will enhance accumulation of the chemotherapeutic agents in the tumor-initiating cells and in turn restores the function of the chemotherapeutic agents in the tumor-initiating cells.
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公开(公告)号：US20240177832A1
公开(公告)日：2024-05-30
申请号：US18173906
申请日：2023-02-24
CPC分类号： G16H30/40 , G06T7/0014 , G06T2207/10088 , G06T2207/20081 , G06T2207/30096
摘要： The present disclosure provides a system and method for precision tumor delineation in cancer treatment or diagnosis for subjects with carcinoma, in particular, nasopharyngeal carcinoma, based on contrast agent-free, virtual contrast-enhanced MRI data (VCE-MRI) synthesized by a modified multimodality-guided synergistic neural network trained with a more diversified training dataset and having a higher generalizability by minimizing data distribution variation between an external dataset and the training dataset through a data distribution matching mechanism before VCE-MRI synthesis.
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138.发明公开公开(公告)号：US20240060072A1
公开(公告)日：2024-02-22
申请号：US18447362
申请日：2023-08-10
发明人： Chi Ming WONG , Mengyao WU
IPC分类号： C12N15/113 , C12N15/86 , A61P1/16
CPC分类号： C12N15/1138 , C12N15/86 , A61P1/16 , C12N2310/11 , C12N2750/14141 , C12N2710/10141
摘要： The present invention provides a method for treating non-alcoholic fatty liver disease (NAFLD), associated conditions and symptoms. In particular, the method includes administering to a subject suffering from or susceptible to NAFLD a composition including therapeutic nucleic acids to reduce G protein-coupled receptor 110 (GPR110) expression in liver. The present invention also provides a pharmaceutical composition for treating NALFD or alleviating conditions and symptoms associated therewith.
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139.发明公开公开(公告)号：US20240037715A1
公开(公告)日：2024-02-01
申请号：US18360850
申请日：2023-07-28
申请人： Benjamin Simon THOMPSON , Centre for Eye and Vision Research Limited , The Hong Kong Polytechnic University
发明人： Benjamin Simon THOMPSON , Chi Ho TO , Yan Yin TSE , Ka Man CHUN , Elie Aymard Jonathan DE LESTRANGE-ANGINIEUR
CPC分类号： G06T5/002 , G02B27/0093 , G06T2207/30041
摘要： Methods, systems and devices for preventing and/or retarding myopia onset and/or progression are provided. Particularly, the system for preventing and/or retarding myopia onset and/or progression including an eye tracker, a display, a controller, and a dynamic blurring filter for the visual content on the display. The display is first presented to a subject, then the eye tracker is employed to detect the movement and the location of the subject's eyes and generate a tracking signal. The tracking signal is further processed by the controller to determine a gaze point of the subject's eye on the display. Based on the gaze point, a dynamic blurring filter is created and applied onto the display.
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公开(公告)号：US11826341B2
公开(公告)日：2023-11-28
申请号：US17650387
申请日：2022-02-09
发明人： Chi Wai Do , Chi ho To , Li Pan , Dongfeng Chen , Kin-Sang Cho
IPC分类号： A61K31/352 , A61P27/02
CPC分类号： A61K31/352 , A61P27/02
摘要： A method of treating an ocular nerve injury in a subject in need thereof, the method comprising administering a therapeutically effective amount of baicalein or an analog thereof.
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