公开(公告)号：US20230158278A1

公开(公告)日：2023-05-25

申请号：US17921686

申请日：2021-05-27

Applicant: NIPRO CORPORATION

Inventor： Natsumi NARUSE ,  Yohei UEHARA ,  Naoaki YASUMURA

IPC: A61M25/09

CPC classification number: A61M25/09 ,  A61M2025/09133 ,  A61M2025/09058 ,  A61M2025/0001

Abstract: A guide wire in which a housing of a sensor is easy to be curved and a slit is hard to fracture. The guide wire includes a core wire, a first helical body, a second helical body, a housing attached to the first helical body and the second helical body, and a pressure sensor located in an internal space of the housing. The housing has slits penetrating a peripheral wall and extending in helices. One of the slits has a central portion extending in the helix in an extending direction and an end portion bent with respect to the central portion along a bending direction.

公开(公告)号：US11529474B2

公开(公告)日：2022-12-20

申请号：US16611744

申请日：2018-05-08

Applicant: NIPRO CORPORATION

Inventor： Hiroyuki Nakagami ,  Shingo Sakamoto

IPC: A61M5/32 ,  A61M5/34 ,  A61M5/31

Abstract: A valved needle assembly including a needle hub provided to a proximal end side of a hollow needle, and a valve member incorporated therein for blocking communication with the hollow needle. A protrusion protrudes from a distal end side toward a proximal end side inside the needle hub and the valve member blocks the proximal end side of the protrusion inside the needle hub. A central valve part of the valve member having a slit moves toward the protrusion such that the slit is opened and placed in communication by the protrusion. The central valve part includes a distal end tubular part and a proximal end tubular part extending from its outer circumferential portion toward the distal end side and the proximal end side respectively.

公开(公告)号：US11448571B2

公开(公告)日：2022-09-20

申请号：US16312387

申请日：2017-07-05

Applicant: NIPRO CORPORATION

Inventor： Toshiaki Baba ,  Koutarou Tanimura ,  Dosaku Tokudome ,  Yukihiro Yabe ,  Kanako Miura

IPC: B01L3/00 ,  G01N1/12 ,  G01N1/00 ,  G01N1/10 ,  G01N1/02 ,  G01N1/14 ,  G01N1/38

Abstract: Provided is a specimen collection tip having a novel structure, with which it is possible to collect a trace amount of a specimen with good quantitative precision. Also provided is a specimen preparation container having a novel structure, with which it is possible to dilute and prepare the specimen collected with the specimen collection tip with good quantitative precision. A specimen collection tip 10, wherein a specimen holding region 12 having a predetermined volume is provided inside the specimen collection tip 10, and in a distal end portion extending from a support part 15, there is formed a specimen collection hole 22 and an air vent hole 24 placing the specimen holding region 12 in communication with a surface 23. Also, a specimen preparation container 26 with a cap 30, wherein the specimen collection tip 10 is attached to the cap 30 at the support part 15.

公开(公告)号：US20220290084A1

公开(公告)日：2022-09-15

申请号：US17625585

申请日：2020-07-07

Applicant: NIPRO CORPORATION

Inventor： Yoshihiro Yoshikawa ,  Masakatsu Takeuchi ,  Masafumi Yao ,  Hideaki Yamamoto ,  Yusuke Wagatsuma ,  Ryosuke Nakamura

IPC: C12M1/12

Abstract: A multilayer culture vessel, comprising a culture vessel part and a reservoir part attached to the culture vessel part, wherein the culture vessel part comprises at least two culture trays that are stacked; the reservoir part comprises a surrounding wall defining an internal space and a port communicating with the internal space; the surrounding wall comprises a first surrounding wall part provided with the port and a second surrounding wall part facing the first surrounding wall part; the culture vessel part has openings communicating individual culture trays of the at least two culture trays with the internal space of the reservoir part; and the openings of the culture vessel part extend toward a first abutting portion that the first surrounding wall part abuts on the culture vessel part from a second abutting portion that the second surrounding wall part abuts on the culture vessel part.

公开(公告)号：US20220283186A1

公开(公告)日：2022-09-08

申请号：US17638044

申请日：2020-08-28

Applicant: NIPRO CORPORATION

Inventor： Hiroshi YOSHIDA ,  Yoshinori KOSOKU ,  Yuka SANO

IPC: G01N33/68

Abstract: The present disclosure provides a method for detecting Alzheimer's cognitive impairment or mild cognitive impairment, comprising: measuring an amount of homocysteic acid in a biological sample from a subject who suffers or possibly suffers from a neurological disease, and detecting Alzheimer's cognitive impairment or mild cognitive impairment based on the measured amount of the homocysteic acid.

公开(公告)号：US11432950B2

公开(公告)日：2022-09-06

申请号：US16495021

申请日：2018-03-22

Applicant: NIPRO CORPORATION

Inventor： Koji Akimoto

IPC: A61F2/88 ,  A61F2/915

Abstract: A stent having a line-shaped body that extends helically in a circumferential direction while reciprocating in an axial direction by continuously alternating straight parts and curved parts, wherein the plurality of straight parts in the line-shaped body have a substantially constant thickness throughout the entire stent, and a certain number of the plurality of curved parts in the line-shaped body have different thicknesses.

公开(公告)号：US20220080129A1

公开(公告)日：2022-03-17

申请号：US17424053

申请日：2020-01-09

Applicant: NIPRO CORPORATION

Inventor： Yuya IGUCHI ,  Koichi KANEMURA

IPC: A61M5/32

Abstract: A syringe cap assembly includes a lock collar to be attached to an ejection port at a proximal end of the syringe, and a plastic cap screwed and thereby tightened into the lock collar. An external surface of the lock collar has projecting ribs that are each extended in an axial direction and are arranged in a circumferential direction to define recessed grooves, each recessed groove is extended in the axial direction and located between adjacent projecting ribs of the projecting ribs, and the adjacent projecting ribs are adjacent to each other in the circumferential direction. A bottom of an external surface of the plastic cap includes a protrusion extending in a direction toward the lock collar. At a stage where a tightening rotation of the plastic cap implemented by screwing the plastic cap into the lock collar is completed, the protrusion is located in the recessed groove between the adjacent projecting ribs.

公开(公告)号：US20210346849A1

公开(公告)日：2021-11-11

申请号：US17278071

申请日：2019-09-18

Applicant: DAICEN MEMBRANE-SYSTEMS Ltd. ,  NIPRO CORPORATION

Inventor： Shuji NAKATSUKA ,  Takashi SUNOHARA ,  Toshinari TAKAHASHI

IPC: B01D69/08 ,  B01D71/68 ,  B01D69/02 ,  B01D63/04 ,  C02F1/44

Abstract: A hollow fiber porous membrane includes polyethersulfone or polysulfone. The hollow fiber porous membrane has an inner diameter from 300 to 600 μm, a thickness from 70 to 200 μm, a molecular weight cut-off of 10000 or lower, and a plurality of pores having a pore diameter from 0.1 to 0.5 μm throughout an outer surface; and a swelling rate of less than 5% as defined below: Swelling Rate (%): for 20 or more of the hollow fiber porous membranes, after a membrane thickness in a cross section of each one of the hollow fiber porous membranes in the width direction is measured at randomly selected 10 or more locations, an average membrane thickness is calculated based on 200 or more locations in total, and the swelling rate is calculated by a formula below: Swelling Rate (%)=(location numbers where the membrane thickness as measured exceeded 1.3 times the average membrane thickness)/(membrane thickness measurement numbers)×100.

公开(公告)号：US20210238563A1

公开(公告)日：2021-08-05

申请号：US16645120

申请日：2018-09-10

Applicant: NIPRO CORPORATION

Inventor： Takashi KIMURA ,  Yasushi TANI

IPC: C12N9/06

Abstract: A mutant glycine oxidase is obtained by substituting at least one wild-type amino acid sequence derived from thermophilic bacteria belonging to the family Bacillus with another amino acid, and has the following enzyme properties. Molecular weight: 40,000±2,000 daltons by SDS-PAGE. Optimum temperature: 45° C. under the condition of pH 8.5 in presence of pyrophosphate. Optimum pH: pH 8.0 under the condition of 37° C. in presence of pyrophosphate. Thermal stability: Stable up to 70° C. under the condition of pH 8.5 while retaining for 1 hour in presence of pyrophosphate. pH Stability: Stable in the range of pH 5.5 to 10.0 under the condition of 4° C. while retaining for 24 hours in presence of pyrophosphate. Specific activity: 1.2 units/mg or more. Kinetic constant Km: 0.2 mM or less.

公开(公告)号：US20210228077A1

公开(公告)日：2021-07-29

申请号：US17258031

申请日：2019-06-18

Applicant: NIPRO Corporation ,  Harada Electronics Industry Co., Ltd.

Inventor： Atsunori Nakano ,  Yoshiharu Kinoshita ,  Katsuhiro Hiejima ,  Tomoyuki Uchida ,  Masahide Harada

IPC: A61B5/00 ,  H04B1/02 ,  A61B5/332 ,  A61B5/0245 ,  A61B5/346

Abstract: An electrocardiographic transmitter executes statistical processes for an electrocardiographic signal to calculate an average value HRav of a heart rate HR in a predetermined period of time. In a case where the average value HRav of the heart rate HR is abnormal, the electrocardiographic transmitter continuously transmits electrocardiogram data based on the electrocardiographic signal to a terminal. The terminal receives and transfers the electrocardiogram data as it is to a host device. The host device stores therein and supplies the transferred electrocardiogram data for a diagnosis by medical worker. Thus, the state of a subject's heart can be monitored over the long term.