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公开(公告)号：USD963887S1
公开(公告)日：2022-09-13
申请号：US29822811
申请日：2022-01-12
Applicant: NIPRO CORPORATION
Designer： Yusuke Wagatsuma , Ryosuke Nakamura , Hideaki Yamamoto , Masafumi Yao , Masakatsu Takeuchi , Yoshihiro Yoshikawa , Shinya Asaka , Naoki Nakagawa
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2.发明授权公开(公告)号：US09738861B2
公开(公告)日：2017-08-22
申请号：US14771358
申请日：2014-02-20
Applicant: KYOTO UNIVERSITY , Nipro Corporation
Inventor： Norio Nakatsuji , Yoshihiro Yoshikawa , Masakatsu Takeuchi , Daiki Tateyama
Abstract: A culture system has a culture bag for suspending and culturing pluripotent stem cells in a culture medium; a waste liquid container for storing used culture medium that is connected to the culture bag; a fresh medium container for storing a fresh culture medium that is connected to the culture bag; three-way stopcocks for switching flow channels from the culture bag to the waste liquid container or the fresh culture medium container, etc.; a trap portion for trapping the pluripotent stem cells in the culture medium in the flow toward the waste liquid container side; and a filter portion for subculturing that is formed in fourth and fifth flow channels in parallel to a first flow channel. The first flow channel connects the trap part to the culture bag, and has a mesh by which a cell mass of the pluripotent stem cells can be divided. A pump is used to pump the liquid in the individual flow channels.
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公开(公告)号：US10975345B2
公开(公告)日：2021-04-13
申请号：US15574516
申请日：2016-05-24
Applicant: Nipro Corporation
Inventor： Masakatsu Takeuchi , Atsushi Taguchi
IPC: C12M3/04 , C12M1/36 , C12M1/00 , C12M1/10 , B01L3/00 , C12M1/06 , C12M1/38 , C12M3/02 , C12M3/00
Abstract: A compact culture device capable of performing large-scale culture in an aseptic state. A culture device has a culture bag which has ports through which a liquid flows and enables cell culture, a bag holding portion having holding plates holding the culture bag and rotating shafts, a rotation mechanism supporting and rotating the rotating shaft, a liquid supply/discharge mechanism supplying and discharging a liquid to/from the culture bag, and a rotation control portion controlling the rotation of the rotation mechanism. The rotation control portion brings the bag holding portion into a first position in parallel with the approximately horizontal direction according to a first information, brings the bag holding portion into a second position when a culture medium in the culture bag is caused to flow out of the port according to a second information, and brings the bag holding portion into a third position in parallel with the approximately vertical direction at least when a cell suspension in the culture bag is caused to flow out of the port according to a third information.
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公开(公告)号：US10883078B2
公开(公告)日：2021-01-05
申请号：US15574546
申请日：2016-05-24
Applicant: Nipro Corporation
Inventor： Norihisa Sasayama , Masakatsu Takeuchi , Atsushi Taguchi
Abstract: A culture device supplying an accurate amount of liquid into a culture bag has a culture bag having ports, a first bag holding portion having supporting surfaces supporting the culture bag, a rotation mechanism rotating the first bag holding portion, a liquid supplying mechanism supplying a liquid through a tube communicating with the ports a weight detector detecting the weight of the culture bag and the first bag holding portion, and a control portion, in which the control portion sets a first reference value according to a first detection information output from the weight detector in a first state and carries out a liquid supplying step of stopping the liquid supplying mechanism under the condition where a second detection information output from the weight detector when a liquid is supplied to the culturing bag reaches a first target value obtained by adding the weight of the liquid to be supplied to the first reference value.
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公开(公告)号：US20220290084A1
公开(公告)日：2022-09-15
申请号：US17625585
申请日：2020-07-07
Applicant: NIPRO CORPORATION
Inventor： Yoshihiro Yoshikawa , Masakatsu Takeuchi , Masafumi Yao , Hideaki Yamamoto , Yusuke Wagatsuma , Ryosuke Nakamura
IPC: C12M1/12
Abstract: A multilayer culture vessel, comprising a culture vessel part and a reservoir part attached to the culture vessel part, wherein the culture vessel part comprises at least two culture trays that are stacked; the reservoir part comprises a surrounding wall defining an internal space and a port communicating with the internal space; the surrounding wall comprises a first surrounding wall part provided with the port and a second surrounding wall part facing the first surrounding wall part; the culture vessel part has openings communicating individual culture trays of the at least two culture trays with the internal space of the reservoir part; and the openings of the culture vessel part extend toward a first abutting portion that the first surrounding wall part abuts on the culture vessel part from a second abutting portion that the second surrounding wall part abuts on the culture vessel part.
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Patent Agency Ranking
公开(公告)号：US20180148680A1
公开(公告)日：2018-05-31
申请号：US15574530
申请日：2016-05-24
Applicant: Norihisa SASAYAMA , Masakatsu TAKEUCHI , Atsushi TAGUCHI , Nipro Corporation
Inventor： Norihisa Sasayama , Masakatsu Takeuchi , Atsushi Taguchi
CPC classification number: C12M47/02 , B01D61/243 , B01D63/02 , B01D63/04 , B01D63/16 , B01D2313/06 , B01D2313/10 , B01D2313/12 , B01D2315/02 , B01D2315/18 , C12M1/10 , C12M3/02 , C12M3/043 , C12M3/06 , C12M3/065 , C12M23/14 , C12M23/42 , C12M23/44 , C12M23/50 , C12M29/04 , C12M29/16 , C12M41/48
Abstract: A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.
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公开(公告)号：USD952898S1
公开(公告)日：2022-05-24
申请号：US29822804
申请日：2022-01-12
Applicant: NIPRO CORPORATION
Designer： Yusuke Wagatsuma , Ryosuke Nakamura , Hideaki Yamamoto , Masafumi Yao , Masakatsu Takeuchi , Yoshihiro Yoshikawa , Shinya Asaka , Naoki Nakagawa
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公开(公告)号：US10793822B2
公开(公告)日：2020-10-06
申请号：US15574530
申请日：2016-05-24
Applicant: Nipro Corporation , Norihisa Sasayama , Masakatsu Takeuchi , Atsushi Taguchi
Inventor： Norihisa Sasayama , Masakatsu Takeuchi , Atsushi Taguchi
IPC: C12M1/00 , C12M1/10 , C12M3/06 , C12M3/00 , B01D63/02 , C12M3/04 , C12M3/02 , B01D63/04 , B01D63/16 , C12M1/36 , B01D61/24
Abstract: A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.
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公开(公告)号：USD961113S1
公开(公告)日：2022-08-16
申请号：US29822782
申请日：2022-01-12
Applicant: NIPRO CORPORATION
Designer： Yusuke Wagatsuma , Ryosuke Nakamura , Hideaki Yamamoto , Masafumi Yao , Masakatsu Takeuchi , Yoshihiro Yoshikawa , Shinya Asaka , Naoki Nakagawa
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公开(公告)号：USD952896S1
公开(公告)日：2022-05-24
申请号：US29732650
申请日：2020-04-27
Applicant: NIPRO CORPORATION
Designer： Yusuke Wagatsuma , Ryosuke Nakamura , Hideaki Yamamoto , Masafumi Yao , Masakatsu Takeuchi , Yoshihiro Yoshikawa , Shinya Asaka , Naoki Nakagawa
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