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公开(公告)号：US10780123B2
公开(公告)日：2020-09-22
申请号：US16833146
申请日：2020-03-27
发明人： Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号： A61K39/00 , A61K35/17 , A61K39/395 , C07K16/24 , A61K39/12 , C12N5/0783 , A61K45/06 , A61P35/02 , C07K14/47 , A61K38/08 , C07K14/54 , C07K7/06 , C07K16/28 , A61K39/39 , A61P35/00 , A61K45/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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132.发明授权公开(公告)号：US10722536B1
公开(公告)日：2020-07-28
申请号：US16839984
申请日：2020-04-03
发明人： Andrea Mahr , Toni Weinschenk , Anita Wiebe , Colette Song , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K35/16 , C12N5/0783 , A61K39/39 , A61K39/00 , A61K35/17
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10702553B2
公开(公告)日：2020-07-07
申请号：US16703034
申请日：2019-12-04
发明人： Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号： A61K39/00 , A61K35/17 , C07K16/28 , C07K14/47 , C07K14/54 , C07K7/06 , A61P35/02 , A61K39/12 , A61K38/08 , C07K16/24 , A61K39/39 , A61K39/395 , C12N5/0783 , A61K45/06 , A61P35/00 , A61K45/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10695377B2
公开(公告)日：2020-06-30
申请号：US16692108
申请日：2019-11-22
发明人： Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号： A61K39/00 , A61K35/17 , C07K14/47 , A61K39/12 , C07K14/54 , C07K7/06 , A61P35/02 , A61K38/08 , C07K16/28 , A61K39/395 , A61K45/06 , A61K39/39 , C12N5/0783 , A61P35/00 , C07K16/24 , A61K45/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10695374B2
公开(公告)日：2020-06-30
申请号：US16659291
申请日：2019-10-21
发明人： Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号： A61K39/00 , A61K35/17 , A61P35/00 , A61K39/39 , C07K16/28 , C07K7/06 , C07K14/54 , A61P35/02 , A61K45/06 , C12N5/0783 , A61K39/12 , C07K16/24 , A61K39/395 , A61K38/08 , C07K14/47 , A61K45/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10683495B2
公开(公告)日：2020-06-16
申请号：US15813879
申请日：2017-11-15
摘要： The present invention relates to improved yeast transformation of yeast cells and yeast cell libraries transformed thereby. More specifically, the present invention relates to the transformation of yeast by electroporation.
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137.发明授权公开(公告)号：US10597433B2
公开(公告)日：2020-03-24
申请号：US16504134
申请日：2019-07-05
发明人： Andrea Mahr , Toni Weinschenk , Valentina Goldfinger , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： C07K14/47 , C07K16/28 , C07K16/30 , A61K39/00 , C07K14/725 , C07K7/06 , G01N33/574 , C12N5/0783 , C07K14/74 , C12N15/115 , C12N15/62
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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138.发明授权公开(公告)号：US10576132B2
公开(公告)日：2020-03-03
申请号：US15982293
申请日：2018-05-17
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , C07K16/28 , C12N15/115 , C07K14/47 , A61P35/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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139.发明授权公开(公告)号：US10561718B2
公开(公告)日：2020-02-18
申请号：US16563096
申请日：2019-09-06
发明人： Toni Weinschenk , Jens Fritsche , Harpreet Singh , Andrea Mahr , Martina Ott , Claudia Wagner , Oliver Schoor
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10548958B2
公开(公告)日：2020-02-04
申请号：US16367790
申请日：2019-03-28
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Colette Song
IPC分类号： A61K39/00 , G16B25/00 , C07K14/47 , A61P35/00 , A61K35/17 , C07K16/18 , C12N5/0783 , C12N15/115 , C07K14/74 , C07K16/28 , C07K16/30 , A61K35/12 , C07K14/705
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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