公开(公告)号：US20160200677A1

公开(公告)日：2016-07-14

申请号：US14963114

申请日：2015-12-08

Applicant: Genomatica, Inc.

Inventor： Rudolf Philippus Maria GUIT ,  Thomas VAN DER DOES ,  Lourina Madeleine RAAMSDONK

IPC: C07D201/08 ,  C07D201/16 ,  C08G69/16

CPC classification number: C07D201/08 ,  C07D201/16 ,  C07D223/10 ,  C08G69/16

Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.

公开(公告)号：US08604188B2

公开(公告)日：2013-12-10

申请号：US13060885

申请日：2009-09-02

Applicant: Theodorus Maria Smeets ,  Leonardus Joseph Raets ,  Cornelis Marinus Van Liujk

Inventor： Theodorus Maria Smeets ,  Leonardus Joseph Raets ,  Cornelis Marinus Van Liujk

IPC: C07D201/16

CPC classification number: C07D201/16

Abstract: The invention relates to a process for extracting an impurity from an organic phase comprising caprolactam, comprising extracting the impurity by washing said organic phase as a discontinuous phase with an aqueous phase as a continuous phase, the ratio of the flow of the aqueous phase in m3/hr, to the flow of the organic phase in m3/hr, being 0.05 or less. Further the invention relates to a caprolactam production plant, wherein use can be made of a process of the invention.

Abstract translation: 本发明涉及一种从含有己内酰胺的有机相中提取杂质的方法，包括通过以水相作连续相洗涤作为不连续相的有机相萃取杂质，水相流量的比例（m3） / hr，有机相流量（m3 / hr）为0.05以下。 此外，本发明涉及己内酰胺生产设备，其中可以使用本发明的方法。

公开(公告)号：US20120330006A1

公开(公告)日：2012-12-27

申请号：US13581777

申请日：2011-03-01

Applicant: Hideto Nagami

Inventor： Hideto Nagami

IPC: C07D201/16

CPC classification number: C07D201/16 ,  C07D223/10

Abstract: An epsilon-caprolactam manufacturing method capable of manufacturing in good yield, high-quality epsilon-caprolactam containing less impurity has an epsilon-caprolactam purification step A of obtaining purified epsilon-caprolactam from raw epsilon-caprolactam by applying a drop crystallization method, a first-stage epsilon-caprolactam recovery step B of obtaining first recovered epsilon-caprolactam and a first recovered mother liquor by applying an evaporative crystallization method to a crystallization mother liquor obtained in the epsilon-caprolactam purification step A, and a second-stage epsilon-caprolactam recovery step C of obtaining second recovered purified epsilon-caprolactam by applying a melt crystallization method to the first recovered mother liquor, first recovered epsilon-caprolactam being recovered as a raw material for the epsilon-caprolactam purification step A and second recovered purified epsilon-caprolactam being recovered as a raw material for the epsilon-caprolactam purification step A and/or the first-stage epsilon-caprolactam recovery step B.

Abstract translation: 能够以良好的产率制造含有较少杂质的高品质ε-己内酰胺的ε-己内酰胺制造方法具有ε-己内酰胺纯化步骤A，其通过应用滴定结晶法从原始ε-己内酰胺获得纯化的ε-己内酰胺，第一 - 阶段ε-己内酰胺回收步骤B，其通过对在ε-己内酰胺纯化步骤A中获得的结晶母液进行蒸发结晶方法获得第一种回收的ε-己内酰胺和第一种回收的母液，以及第二级ε-己内酰胺 回收步骤C，通过对第一回收母液进行熔融结晶法获得第二回收的纯化ε-己内酰胺，首先回收ε-己内酰胺纯化步骤A的原料中回收的ε-己内酰胺和第二回收纯化的ε-己内酰胺 作为ε-caprolac的原料回收 提纯步骤A和/或第一阶段ε-己内酰胺回收步骤B.

公开(公告)号：US07141668B2

公开(公告)日：2006-11-28

申请号：US10495862

申请日：2002-11-25

Applicant: Theodorus M Smeets ,  Gerardus W. A. Hangx

Inventor： Theodorus M Smeets ,  Gerardus W. A. Hangx

IPC: C07D201/16

CPC classification number: C07D223/10 ,  B01D3/146 ,  B01D5/0036 ,  C07D201/16

Abstract: The invention relates to a process for recovering caprolactam from a mixture comprising caprolactam, water, light and heavy components, by subjecting the mixture to a first vacuum distillation resulting in a first bottom product comprising heavy components and caprolactam and in a fist overhead product comprising caprolactam, water, unsaturated lactams and light components; and subjecting at least part of the unsaturated lactams to a hydrogenation.

Abstract translation: 本发明涉及一种从包含己内酰胺，水，轻和重组分的混合物中回收己内酰胺的方法，该方法是使混合物进行第一次真空蒸馏，得到包含重组分和己内酰胺的第一底部产物，以及包含己内酰胺 ，水，不饱和内酰胺和轻组分; 并使至少部分不饱和内酰胺进行氢化。

公开(公告)号：US07060819B2

公开(公告)日：2006-06-13

申请号：US10663479

申请日：2003-09-15

Applicant: Alan Martin Allgeier ,  John J. Ostermaier

Inventor： Alan Martin Allgeier ,  John J. Ostermaier

IPC: C07D201/16 ,  C07D223/02

CPC classification number: C07C253/30 ,  C07C209/48 ,  C07C209/84 ,  C07C211/12 ,  C07C255/24

Abstract: Process for making both ACN and HMD from partial hydrogenation of ADN by using a combination of distillations resulting in the formation of a mixture of HMD and THA that can be hydrogenated to produce a mixture of HMD and HMI that can be separated easily by simple distillation.

Abstract translation: 通过使用蒸馏组合形成ACN和HMD来制备HMD和THA的混合物，可以被氢化以产生可通过简单蒸馏容易地分离的HMD和HMI的混合物来制备ADN的部分氢化的方法。

公开(公告)号：US07022844B2

公开(公告)日：2006-04-04

申请号：US10251335

申请日：2002-09-21

Applicant: Alan Levy ,  Gregory Cleotelis, II ,  James Sawyer ,  Nolan Henrich, III ,  Mohammed Loya ,  Matthew Warren ,  Gregory Moore

Inventor： Alan Levy ,  Gregory Cleotelis, II ,  James Sawyer ,  Nolan Henrich, III ,  Mohammed Loya ,  Matthew Warren ,  Gregory Moore

IPC: C07D201/04 ,  C07D201/16

CPC classification number: C07D201/04

Abstract: Methods are disclosed of producing and purifying at least one amide. In accordance with one of the methods disclosed herein, the at least one amide is produced by providing an organic liquid comprising at least one oxime, providing at least one catalyst, adding the at least one catalyst to the organic liquid to form a rearrangement mass, wherein the rearrangement mass comprises at least one amide, at least one impurity, and the at least one catalyst, and heating the rearrangement mass to a temperature of at least about 115° C. for a period of time in order to sulfonate, break down and/or reduce the concentration of some of the at least one impurity in the rearrangement mass.

公开(公告)号：US20050176954A1

公开(公告)日：2005-08-11

申请号：US10495862

申请日：2002-11-25

Applicant: Theodorus Smeets ,  Gerardus Hangx

Inventor： Theodorus Smeets ,  Gerardus Hangx

IPC: B01D3/14 ,  B01D5/00 ,  C07D201/16 ,  C07D223/10

CPC classification number: C07D223/10 ,  B01D3/146 ,  B01D5/0036 ,  C07D201/16

Abstract: The invention relates to a process for recovering caprolactam from a mixture comprising caprolactam, water, light and heavy components, by subjecting the mixture to a first vacuum distillation resulting in a first bottom product comprising heavy components and caprolactam and in a fist overhead product comprising caprolactam, water, unsaturated lactams and light components; and subjecting at least part of the unsaturated lactams to a hydrogenation.

Abstract translation: 本发明涉及一种从包含己内酰胺，水，轻和重组分的混合物中回收己内酰胺的方法，该方法是使混合物进行第一次真空蒸馏，得到包含重组分和己内酰胺的第一底部产物，以及包含己内酰胺 ，水，不饱和内酰胺和轻组分; 并使至少部分不饱和内酰胺进行氢化。

公开(公告)号：US20030100751A1

公开(公告)日：2003-05-29

申请号：US10151687

申请日：2002-05-20

Inventor： Thomas Mueller ,  Markus Ansorge

IPC: C07D213/08 ,  C07D241/02 ,  C07D201/16

CPC classification number: C07D231/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates to a process for the preparation of heterocycles, characterised in that the following components: i) a propargyl derivative of the general structural formula I 1 wherein Het is an optionally substituted hetero atom and A is a substituted or unsubstituted aromatic entity, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkyne, an acceptor group or a nitrile; (ii) a compound of the general structural formula II BnullXnullnullII,wherein B is an electron-deficient substituted or unsubstituted aromatic entity with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic entity with or without an acceptor group, an electron-deficient olefin and/or alkyne, a metal complex, and X is a leaving group; (iii) a nucleophile of the general structural formula III YnullCnnullZnullnullIII,wherein Y and/or Z, each independently of the other, is an amino group, thio group (mercapto group), seleno group, telluro group, hydroxy group (alcohol group), imido group, carbonyl group, thiocarbonyl group, selenocarbonyl group, tellurocarbonyl group; C is a substituted or unsubstituted C atom, a substituted or unsubstituted or annelated CC double bond or single bond and nnull0-10, preferably 1-5, preferably are reacted in a one-pot reaction by cyclocondensation to form 4- to 10-membered, preferably 5- to 7-membered, heterocyclic, aromatic or non-aromatic ring systems.

Abstract translation: 本发明涉及一种制备杂环的方法，其特征在于以下组分：i）一般结构式I的炔丙基衍生物，其中Het是任选取代的杂原子，A是取代或未取代的芳族实体，取代的 或未取代的芳族杂环，取代或未取代的乙烯基芳烃和/或其衍生物，烯烃，炔烃，受体基团或腈; （ii）一般结构式II BX II的化合物，其中B是具有或不具有受体基团的电子缺乏的取代或未取代的芳族实体，具有或不具有受体基团的电子缺乏的取代或未取代的杂芳族实体， 电子缺乏烯烃和/或炔烃，金属络合物，X是离去基团; （iii）一般结构式III Y-Cn-Z III的亲核试剂，其中Y和/或Z各自独立地为氨基，硫基（巯基），硒基，碲基，羟基 基团（醇基），亚氨基，羰基，硫代羰基，硒羰基，桥联羰基; C是取代或未取代的C原子，取代或未取代或未被取代的CC双键或单键，n = 0-10，优选1-5，优选在一釜反应中通过环化缩合反应形成4-至10 优选5-至7-元杂环，芳族或非芳族环体系。

公开(公告)号：US20020086995A1

公开(公告)日：2002-07-04

申请号：US09993872

申请日：2001-11-16

Inventor： David R. Kronenthal ,  Rajendra P. Deshpande ,  James Simpson

IPC: C07D491/02 ,  C07D471/02 ,  C07D201/16

CPC classification number: C07D513/04 ,  C07D223/12

Abstract: Mercaptoalkanoylamino lactam acids are recrystallized by treatment with an agent that minimizes the formation of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite.

公开(公告)号：US5994565A

公开(公告)日：1999-11-30

申请号：US271966

申请日：1999-03-18

Applicant: Kazuo Tanaka ,  Atsushi Okoshi ,  Hiroshi Ogawa

Inventor： Kazuo Tanaka ,  Atsushi Okoshi ,  Hiroshi Ogawa

IPC: C07D201/16 ,  C07D313/04

CPC classification number: C07D313/04

Abstract: A process for producing purified .epsilon.-caprolactone from an .epsilon.-caprolactone-containing reaction product produced by the oxidation of cyclohexanone comprising subjecting the .epsilon.-caprolactone-containing reaction product to an alkali-treatment in the presence of an inert gas atmosphere or to a heat treatment in the presence of an inert gas atmosphere or to a combined alkali-treatment and heat treatment, and distilling the treated reaction product.

Abstract translation: 由通过环己酮氧化制备的含有ε-己内酯的反应产物制备纯化的ε-己内酯的方法，包括在含有ε-己内酯的反应产物在惰性气体气氛或热的存在下进行碱处理 在惰性气体气氛的存在下进行处理或进行组合的碱处理和热处理，并蒸馏处理的反应产物。