公开(公告)号：USD949132S1

公开(公告)日：2022-04-19

申请号：US29788078

申请日：2021-03-09

Applicant: Galvani Bioelectronics Limited

Designer： Peng Cong ,  Damiano Patron ,  Stephen O'Driscoll

公开(公告)号：US11298544B2

公开(公告)日：2022-04-12

申请号：US15999427

申请日：2017-02-17

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc Pepin ,  Brian Otis

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61N1/378 ,  H02J50/10 ,  H02J50/20 ,  H02J50/40 ,  H02J50/80 ,  H02J7/02 ,  H02J7/34

Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.

公开(公告)号：USD947119S1

公开(公告)日：2022-03-29

申请号：US29693986

申请日：2019-06-06

Applicant: GALVANI BIOELECTRONICS LIMITED

Designer： Jay Canham ,  David Lari ,  Cindy Au ,  Melissa Lara ,  Daniel Nobre ,  Ryan Jongwoo Choi

公开(公告)号：US20220080208A1

公开(公告)日：2022-03-17

申请号：US17415599

申请日：2019-12-13

Applicant: Galvani Bioelectronics Limited

Inventor： David Karl Lee Peterson ,  Daniel John Chew ,  Matteo Donega ,  Xu Meng

IPC: A61N1/36 ,  A61N1/05

Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.

公开(公告)号：US20210402191A1

公开(公告)日：2021-12-30

申请号：US17279032

申请日：2019-09-23

Applicant: Galvani Bioelectronics Limited

Inventor： Alexander Loo ,  Peng Cong ,  David K. Peterson

IPC: A61N1/372 ,  A61N1/375 ,  A61N1/378 ,  A61N1/36

Abstract: An implantable pulse generator is provided that includes a power source, a wireless communication component configured to facilitate wireless communication with a non-implanted device and pulse-generating circuitry connected to the power source. The pulse-generating circuitry can be configured to identify, based on wireless communication with the non-implanted device, temporal and amplitude characteristics for electrical pulse stimuli and to trigger electrical output stimuli having the temporal and amplitude characteristics. The implantable pulse generation can further include one or more lead connections—each being shaped to engage a lead and electrically connected to the pulse-generating circuitry to enable the lead to deliver at least part of the electrical output stimuli triggered by the pulse-generating circuitry. The implantable pulse generator can further include one or more suture-engagement components, each including one or more holes each having a diameter that is at least 0.1 mm and less than 5 mm.

公开(公告)号：US11097115B2

公开(公告)日：2021-08-24

申请号：US16140471

申请日：2018-09-24

Applicant: Galvani Bioelectronics Limited

Inventor： Peng Cong

IPC: A61N1/00 ,  A61N1/375 ,  A61B17/34 ,  A61N1/372 ,  A61B17/04 ,  A61N1/378 ,  A61N1/36

Abstract: An implantable pulse generator is provided that includes a power source, a wireless communication component configured to facilitate wireless communication with a non-implanted device and pulse-generating circuitry connected to the power source. The pulse-generating circuitry can be configured to identify, based on wireless communication with the non-implanted device, temporal and amplitude characteristics for electrical pulse stimuli and to trigger electrical output stimuli having the temporal and amplitude characteristics. The implantable pulse generation can further include one or more lead connections—each being shaped to engage a lead and electrically connected to the pulse-generating circuitry to enable the lead to deliver at least part of the electrical output stimuli triggered by the pulse-generating circuitry. The implantable pulse generator can further include one or more suture-engagement components, each including one or more holes each having a diameter that is at least 0.1 mm and less than 5 mm.

公开(公告)号：US20210178153A1

公开(公告)日：2021-06-17

申请号：US17248735

申请日：2021-02-05

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal ZAIDI ,  Sabastien OUCHOUCHE ,  Paul MATTEUCCI

IPC: A61N1/05 ,  A61K9/00 ,  A61K31/56 ,  A61N1/36 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed comprising three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce never compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.

公开(公告)号：US20210154485A1

公开(公告)日：2021-05-27

申请号：US17164350

申请日：2021-02-01

Applicant: Galvani Bioelectronics Limited

Inventor： Rizwan BASHIRULLAH

IPC: A61N1/378 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  H04B5/00 ,  A61N1/375 ,  A61B5/00

Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device

公开(公告)号：US10974041B2

公开(公告)日：2021-04-13

申请号：US15568964

申请日：2016-04-22

Applicant: GALVANI BIOELECTRONICS LIMITED ,  ACADEMISCH MEDISCH CENTRUM

Inventor： Daniel John Chew ,  Wouter Jacob De Jonge ,  Hans Jakob Kristoffer Famm ,  Sonal Patel ,  Olaf Welting

IPC: A61N1/36 ,  A61N1/05

Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.

公开(公告)号：US20210093868A1

公开(公告)日：2021-04-01

申请号：US15733223

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER

IPC: A61N1/36 ,  A61N1/05

Abstract: There is provided a neural interface device for unidirectional stimulation of a nerve including at least one A-type nerve fiber or at least one at least partially myelinated nerve fiber. The device includes an electrode arrangement for placing on or around the nerve. The electrode arrangement includes a first electrode configured to be positively charged and a second electrode configured to be negatively charged, where the surface area of the second electrode is larger than the surface area of first electrode.