公开(公告)号：US20140364372A1

公开(公告)日：2014-12-11

申请号：US14471262

申请日：2014-08-28

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Dan DEUTSCH ,  Amir Haze ,  Anat Blumenfeld

IPC: C07K14/78

CPC classification number: C07K14/78 ,  A61K38/39

Abstract: A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of amelogenin.

Abstract translation: 治疗有需要的受试者对透明软骨损伤的方法。 该方法包括向受试者施用治疗有效量的牙釉蛋白。

公开(公告)号：US20140295454A1

公开(公告)日：2014-10-02

申请号：US14304948

申请日：2014-06-15

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Eli KESHET ,  Shay Sela ,  Ahuva Itin ,  Simcha Yagel

IPC: G01N33/68

CPC classification number: G01N33/689 ,  C07K14/71

Abstract: An isolated polypeptide comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed.

Abstract translation: 公开了包含与SEQ ID NO：4至少70％同源的氨基酸序列的分离的多肽和编码该多肽的分离的多核苷酸。 还公开了包含能够与分离的多核苷酸特异性杂交的核酸序列的多核苷酸和包含特异性结合分离的多肽的抗原识别结构域的分离的抗体。 还公开了药物组合物，包含其的诊断和治疗方法。

公开(公告)号：US20020128553A1

公开(公告)日：2002-09-12

申请号：US09802928

申请日：2001-03-12

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Eyal Mishani ,  Iris Ben-David ,  Yulia Rozen ,  Gluseppina Ortu ,  Alexander Levitzki

IPC: A61K051/00

CPC classification number: A61K51/0459

Abstract: Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.

Abstract translation: 公开了放射性标记的表皮生长因子受体酪氨酸激酶（EGFR-TK）不可逆抑制剂及其作为药物放射成像的生物标志物，如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）以及放射治疗放射性药物。

公开(公告)号：US12065435B2

公开(公告)日：2024-08-20

申请号：US17975214

申请日：2022-10-27

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Or Kakhlon ,  Miguel Enrique Weil ,  Leonardo Javier Solmesky

IPC: C07D409/12 ,  A61P25/28 ,  C07D487/08

CPC classification number: C07D409/12 ,  A61P25/28 ,  C07D487/08

Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.

公开(公告)号：US20240175867A1

公开(公告)日：2024-05-30

申请号：US18389293

申请日：2023-11-14

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Batia AVNI ,  Benjamin GLASER ,  Yuval DOR ,  Ruth SHEMER

IPC: G01N33/53 ,  G01N33/68

CPC classification number: G01N33/5308 ,  G01N33/6863 ,  G01N2800/245

Abstract: Methods of diagnosing graft versus host disease (GVHD) comprising quantifying cfDNA or employing a machine learning model are provided. Methods comprising training a machine learning model are also provided.

公开(公告)号：US11801220B2

公开(公告)日：2023-10-31

申请号：US16184079

申请日：2018-11-08

Applicant: Hadasit Medical Research Services and Development Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Ruth Gabizon ,  Haim Ovadia ,  Oded Abramsky ,  Shlomo Magdassi ,  Liraz Larush

IPC: A61K9/107 ,  A23L33/115 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61K31/202 ,  A61K36/185 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22

CPC classification number: A61K9/107 ,  A23L33/115 ,  A61K9/1075 ,  A61K31/202 ,  A61K36/185 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44

Abstract: The present invention relates to the use of pomegranate oil and fractions thereof for preventing and treating neurodegenerative diseases. Particularly, the present invention relates to emulsions of the pomegranate oil or fractions thereof for the prevention and treatment of brain diseases, including Creutzfeldt-Jacob disease (CJD) and multiple sclerosis (MS).

公开(公告)号：US11718666B2

公开(公告)日：2023-08-08

申请号：US17388218

申请日：2021-07-29

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Rifaat Safadi

IPC: C07K16/28 ,  A61K38/16 ,  A61K38/17 ,  A61P1/16 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/16 ,  A61K38/177 ,  A61K38/1709 ,  A61P1/16 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/76 ,  C07K2319/30

Abstract: Method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a therapeutically effective amount of an agent capable of interfering with, inhibiting and/or preventing neuroligin 4 (NLGn4)-Neurexin 1-beta (Nrx1b) protein-protein interaction; and compositions including the agent.

公开(公告)号：US20230212674A1

公开(公告)日：2023-07-06

申请号：US18147647

申请日：2022-12-28

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  GRAIL, LLC

Inventor： TOMER KAPLAN ,  YUVAL DOR ,  RUTH SHEMER ,  BENJAMIN GLASER

IPC: C12Q1/6881 ,  C12Q1/6883

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/154

Abstract: The present disclosure relates generally to compositions and methods for determining cell type based on a methylation profile of associated DNA. For cell free DNA, such determination can be used to identify disease or conditions relating to the cell type. For tumor cells, such determination is useful for identifying their primary origin.

公开(公告)号：US20230149418A1

公开(公告)日：2023-05-18

申请号：US18157438

申请日：2023-01-20

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Dana WOLF

IPC: A61K31/541 ,  A61P31/12 ,  A61K31/517 ,  A61K31/522 ,  A61K31/675 ,  A61K31/7056

CPC classification number: A61K31/541 ,  A61K31/517 ,  A61K31/522 ,  A61K31/675 ,  A61K31/7056 ,  A61P31/12

Abstract: The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising use of artemisone in combination with at least one antiviral compound selected from maribavir, cidofovir, brincidofovir, valganciclovir, and letermovir, and the combination provides a synergistic anti-viral effect. The invention also provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisone in combination with ganciclovir, wherein the molar ratio between artemisone and ganciclovir is about 1:100 to 100:1, and the combination provides a synergistic anti-viral effect. Pharmaceutical compositions comprising artemisone and at least one of said antiviral compounds are provided as well.

公开(公告)号：US20220184154A1

公开(公告)日：2022-06-16

申请号：US17681946

申请日：2022-02-28

Applicant: Yeda Research and Development Co. Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Eran ELINAV ,  Yotam COHEN ,  Ahinoam LEV-SAGIE ,  Debra GOLDMAN-WOHL

IPC: A61K35/747 ,  A61P31/04

Abstract: A method of treating bacterial vaginosis in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a composition which comprises between three and twenty species of bacteria or a secretion thereof, wherein at least 70% of the bacteria of the composition are of the species Lactobacillus crispatus, thereby treating the bacterial vaginosis.