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254 条记录 (耗时 0.056 秒)

    Macrocyclic oximyl hepatitis C serine protease inhibitors
    141.
    发明授权
    Macrocyclic oximyl hepatitis C serine protease inhibitors 有权
    大环肟基丙型肝炎丝氨酸蛋白酶抑制剂

    公开(公告)号：US08222203B2

    公开(公告)日：2012-07-17

    申请号：US12333457

    申请日：2008-12-12

    申请人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    发明人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/00

    CPC分类号： C07K5/0812 ,  A61K38/00 ,  C07K5/06165

    摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，酯或前体药物：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    System and method for automatic registration of 4D (3D plus time) renal perfusion MRI data
    143.
    发明授权
    System and method for automatic registration of 4D (3D plus time) renal perfusion MRI data 有权
    自动注册4D（3D加时间）肾灌注MRI数据的系统和方法

    公开(公告)号：US08150133B2

    公开(公告)日：2012-04-03

    申请号：US12421862

    申请日：2009-04-10

    申请人： Ying Sun ,  Gareth Funka-Lea

    发明人： Ying Sun ,  Gareth Funka-Lea

    IPC分类号： G06K9/00

    CPC分类号： G06T7/33 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30084

    摘要： A method for registering digital renal perfusion images includes selecting a volume of interest (VOI) containing a kidney in a reference renal perfusion image, computing 3D intensity gradients for a plurality of points in the VOI of the reference renal perfusion image, computing 3D intensity gradients for a plurality of points in a search window of a current renal perfusion image, and maximizing a similarity measure between the reference image VOI and the current image search window, where the similarity measure is a function of the 3D intensity gradients computed for the reference image and the current image.

    摘要翻译： 用于登记数字肾灌注图像的方法包括在参考肾灌注图像中选择包含肾脏的感兴趣体积（VOI），计算参考肾灌注图像的VOI中的多个点的3D强度梯度，计算3D强度梯度 对于当前肾灌注图像的搜索窗口中的多个点，并且使参考图像VOI和当前图像搜索窗口之间的相似性度量最大化，其中相似性度量是针对参考图像计算的3D强度梯度的函数 和当前图像。

    Method And A Device In A Wireless Communication System
    144.
    发明申请
    Method And A Device In A Wireless Communication System 有权
    无线通信系统中的方法和设备

    公开(公告)号：US20110143766A1

    公开(公告)日：2011-06-16

    申请号：US13058661

    申请日：2008-08-12

    申请人： Ying Sun ,  Girum Fantaye ,  Christian Skarby

    发明人： Ying Sun ,  Girum Fantaye ,  Christian Skarby

    IPC分类号： H04W72/08

    CPC分类号： H04L1/0027 ,  H04L1/0025

    摘要： In a wireless communication system, a base station adaptively schedule CQI reports form mobile stations. By adaptively prioritizing the CQI report from the mobile station against the uplink traffic and control data, the CQI reporting rate avoids unnecessary overhead in the uplink while maintaining good performance. The CQI reports are requested in response to a calculated weighting factor which is based on channel coherence time that can be estimated by the base station. The adaptivity in the CQI reporting allows achieving an optimal tradeoff between uplink traffic data and downlink control feedback signaling.

    摘要翻译： 在无线通信系统中，基站从移动台自适应地调度CQI报告。 通过对来自移动台的CQI报告对上行流量和控制数据进行自适应优先排序，CQI报告速率避免了上行链路中不必要的开销，同时保持了良好的性能。 响应于基于可由基站估计的信道相干时间的计算的加权因子来请求CQI报告。 CQI报告中的适应性允许在上行链路业务数据和下行链路控制反馈信令之间实现最佳权衡。

    SYSTEM AND METHOD FOR AUTOMATIC REGISTRATION OF 4D (3D PLUS TIME) RENAL PERFUSION MRI DATA
    146.
    发明申请
    SYSTEM AND METHOD FOR AUTOMATIC REGISTRATION OF 4D (3D PLUS TIME) RENAL PERFUSION MRI DATA 有权
    自动注册4D（3D加时间）RENAL PERFUSION MRI数据的系统和方法

    公开(公告)号：US20090324043A1

    公开(公告)日：2009-12-31

    申请号：US12421862

    申请日：2009-04-10

    申请人： Ying Sun ,  Gareth Funka-Lea

    发明人： Ying Sun ,  Gareth Funka-Lea

    IPC分类号： G06K9/00

    CPC分类号： G06T7/33 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30084

    摘要： A method for registering digital renal perfusion images includes selecting a volume of interest (VOI) containing a kidney in a reference renal perfusion image, computing 3D intensity gradients for a plurality of points in the VOI of the reference renal perfusion image, computing 3D intensity gradients for a plurality of points in a search window of a current renal perfusion image, and maximizing a similarity measure between the reference image VOI and the current image search window, where the similarity measure is a function of the 3D intensity gradients computed for the reference image and the current image.

    摘要翻译： 用于登记数字肾灌注图像的方法包括在参考肾灌注图像中选择包含肾脏的感兴趣体积（VOI），计算参考肾灌注图像的VOI中的多个点的3D强度梯度，计算3D强度梯度 对于当前肾灌注图像的搜索窗口中的多个点，并且使参考图像VOI和当前图像搜索窗口之间的相似性度量最大化，其中相似性度量是针对参考图像计算的3D强度梯度的函数 和当前图像。

    SYSTEM AND METHOD FOR GENERATING MR MYOCARDIAL PERFUSION MAPS WITHOUT USER INTERACTION
    147.
    发明申请
    SYSTEM AND METHOD FOR GENERATING MR MYOCARDIAL PERFUSION MAPS WITHOUT USER INTERACTION 有权
    用于在没有用户交互的情况下产生MR MYOCARDIAL PERFUSION MAPS的系统和方法

    公开(公告)号：US20090290778A1

    公开(公告)日：2009-11-26

    申请号：US12431888

    申请日：2009-04-29

    申请人： Ying Sun ,  Jens Gühring

    发明人： Ying Sun ,  Jens Gühring

    IPC分类号： G06K9/00

    CPC分类号： G06K9/3233 ,  G06K9/342 ,  G06K9/6207 ,  G06K2209/051 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10076 ,  G06T2207/30048

    摘要： A method for automatically generating a myocardial perfusion map from a sequence of magnetic resonance (MR) images includes determining a region of interest (ROI) in a reference frame selected from a time series of myocardial perfusion MR image slices, registering each image slice in the time series of slices to the reference frame to obtain a series of registered ROIs, and using the series of registered ROIs to segment endo- and epi-cardial boundaries of a myocardium in the ROI.

    摘要翻译： 从磁共振（MR）图像序列自动生成心肌灌注图的方法包括确定选自心肌灌注MR图像切片的时间序列的参考帧中的感兴趣区域（ROI），将每个图像切片记录在 时间序列切片到参考帧以获得一系列注册的ROI，并且使用一系列注册的ROI来分割ROI中的心肌的内部和外部的边界。

    Apparatus for changing bits of machine tool
    149.
    发明授权
    Apparatus for changing bits of machine tool 失效
    用于更换机床位的装置

    公开(公告)号：US07578776B1

    公开(公告)日：2009-08-25

    申请号：US12229007

    申请日：2008-08-19

    申请人： Ying Sun ,  Chi Sun

    发明人： Ying Sun ,  Chi Sun

    IPC分类号： B23Q3/157

    CPC分类号： B23Q3/15706 ,  B23Q3/15534 ,  Y10S483/90 ,  Y10T483/1755 ,  Y10T483/1795

    摘要： A machine tool is provided with a bit-changing apparatus including a cam, a rocker, a roller, a linkage, a pulling element, a disc and clips. The cam is attached to the machine tool. The roller is attached to the rocker and movable against the cam. The linkage includes two connecting rods each formed with an end pivotally connected to the machine tool and another end pivotally connected to the rocker. The pulling element is provided between the rocker and the machine tool so that the roller is kept against the cam. The disc is rotationally supported on the rocker. Each of the clips is attached to the disc and used to clip a holder for holding a bit so that a selected bit can be engaged with a bit-driving unit of the machine tool.

    摘要翻译： 一种机床设置有包括凸轮，摇杆，滚子，连杆机构，牵引元件，圆盘和夹子的位移装置。 凸轮连接到机床上。 滚轮安装在摇臂上，可抵靠凸轮移动。 联动装置包括两个连接杆，每个连接杆形成有可枢转地连接到机床的端部，另一端枢转地连接到摇臂。 牵引元件设置在摇杆和机床之间，使得辊保持抵靠凸轮。 盘被旋转地支撑在摇杆上。 每个夹子连接到盘上，并用于夹持保持器以保持位，使得所选择的位可以与机床的位驱动单元接合。

    OXIMYL MACROCYCLIC DERIVATIVES
    150.
    发明申请
    OXIMYL MACROCYCLIC DERIVATIVES 有权
    OXIMYL MACROCYCLIC衍生物

    公开(公告)号：US20090191153A1

    公开(公告)日：2009-07-30

    申请号：US12327453

    申请日：2008-12-03

    申请人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

    发明人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K31/407 ,  C07D487/04 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/497 ,  A61K31/427 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/55 ,  A61P31/12 ,  A61K38/21 ,  A61K31/708

    CPC分类号： C07D245/04

    摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，酯或前体药物：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。