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公开(公告)号：US11970544B2
公开(公告)日：2024-04-30
申请号：US17353087
申请日：2021-06-21
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
CPC classification number: C07K16/30 , A61P35/00 , C12N15/79 , A61K2039/505 , C07K2317/31 , C07K2317/51 , C07K2317/565
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US11939388B2
公开(公告)日：2024-03-26
申请号：US17360437
申请日：2021-06-28
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil Altintas , David Satijn , Rik Rademaker , Paul Parren , Friederike Gieseke , Ugur Sahin
IPC: C07K16/28 , A61K39/395 , G01N33/569
CPC classification number: C07K16/2878 , A61K39/3955 , G01N33/56972 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/92
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US11866514B2
公开(公告)日：2024-01-09
申请号：US16777053
申请日：2020-01-30
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
CPC classification number: C07K16/468 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , G01N33/6854 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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公开(公告)号：US11858995B2
公开(公告)日：2024-01-02
申请号：US17559935
申请日：2021-12-22
Applicant: GENMAB A/S
Inventor： Brian Elliott , Jenny Jianlin Chen , Tahamtan Ahmadi , Christopher W. L. Chiu , Esther C. W. Breij , Ida Hiemstra , Maria N. Jure-Kunkel
CPC classification number: C07K16/2809 , C07K16/2887 , A61K2039/507 , A61K2039/545 , C07K2317/24 , C07K2317/31
Abstract: Provided are methods of clinical treatment of chronic lymphoblastic leukemia (CLL) in human subjects using a bispecific antibody which binds to CD3 and CD20.
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155.发明公开公开(公告)号：US20230312759A1
公开(公告)日：2023-10-05
申请号：US18025208
申请日：2021-09-10
Applicant: GENMAB A/S
Inventor： Brian ELLIOTT , Tahamtan AHMADI , Patricia GARRIDO CASTRO
CPC classification number: C07K16/468 , A61P35/00 , C07K2317/565 , C07K2317/31
Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., relapsed and/or refractory DLBCL ineligible for autologous stem cell transplant) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of car regimen of gemcitabine and oxaliplatin (GemOx).
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Patent Agency Ranking
156.发明公开公开(公告)号：US20230312757A1
公开(公告)日：2023-10-05
申请号：US18025202
申请日：2021-09-10
Applicant: GENMAB A/S
Inventor： Brian ELLIOTT , Jenny J. CHEN , Tahamtan AHMADI , Christopher W.L. CHIU , Esther C.W. BRElJ , Ida HIEMSTRA , Maria N. JURE-KUNKEL
CPC classification number: C07K16/468 , A61P35/00 , C07K2317/565 , C07K2317/31
Abstract: Provided are methods of clinical treatment of chromic lymphoblastic leukemia (CLL) inhuman subjects using a bispecific-antibody which binds to CD3 and CD20.
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公开(公告)号：US20230295335A1
公开(公告)日：2023-09-21
申请号：US18184120
申请日：2023-03-15
Applicant: Genmab A/S , BioNTech SE
Inventor： Andreea IOAN , Esther Cornelia Wilhelmina BREIJ , Lars GUELEN , David P.E. SATIJN , Ugur SAHIN , Alexander MUIK , Kristina SCHÖDEL , Sina FELLERMEIER-KOPF , Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran Frank LABRIJN
CPC classification number: C07K16/30 , C07K16/2878 , C07K2317/31 , C07K2317/92
Abstract: The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.
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公开(公告)号：US20230272105A1
公开(公告)日：2023-08-31
申请号：US17792268
申请日：2021-01-15
Applicant: GENMAB A/S
Inventor： Jacob D. CLAUSEN , Richard HIBBERT , Michael B. DALGAARD
CPC classification number: C07K16/2896 , A61K47/22 , A61K47/12 , A61K47/26 , C07K2317/35 , C07K2317/92 , C07K2317/76 , C07K2317/73
Abstract: The present invention provides pharmaceutical formulations comprising antibodies binding to CD38 and to the use of said formulations in the treatment of cancer and other indications.
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公开(公告)号：US20230027394A1
公开(公告)日：2023-01-26
申请号：US17739934
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil Altintas , Patrick Engelberts , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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160.发明申请公开(公告)号：US20220411505A1
公开(公告)日：2022-12-29
申请号：US17635258
申请日：2020-08-14
Applicant: GENMAB A/S
Inventor： Jesper VALBJOERN , Lene Schantz HARLOW , Jacob Dahlqvist CLAUSEN , Mette Hamborg JENSEN , Christian CIMANDER , Jesper PASS , Peter Juul MADSEN , Shan REN , Maria Anna Cecilia WAHLBOM , Bolette BJERREGAARD
Abstract: The present invention relates to improved pharmaceutical compositions and dosage unit forms of bispecific CD3×CD20 antibodies and to routes of administration.
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