公开(公告)号：USRE42933E1

公开(公告)日：2011-11-15

申请号：US11900901

申请日：2007-09-13

申请人： Zhengnian Tang ,  Julio C. Spinelli ,  Jeffrey E. Stahmann ,  Rene H. Wentkowski ,  Andrew P. Kramer ,  Paul A. Haefner

发明人： Zhengnian Tang ,  Julio C. Spinelli ,  Jeffrey E. Stahmann ,  Rene H. Wentkowski ,  Andrew P. Kramer ,  Paul A. Haefner

IPC分类号： A61N1/00

CPC分类号： A61N1/3704 ,  A61N1/3712

摘要： A cardiac rhythm management device that utilizes blanking or refractory periods to avoid misidentification of artifacts and evoked potentials, wherein the refractory periods are discontinuous and may be dependent upon sensed events, expiration of a predefined timing interval, or stimulation events in the same or other chambers of the heart. The discontinuous refractory periods enhance the ability of the device to sense intrinsic events. The present invention includes separate refractory and floating refractory periods incorporated within the sensing protocol for each selected cycle, thereby increasing the time period for normal sensing.

摘要翻译： 一种心律管理装置，其利用消隐期或难治期以避免伪像和诱发电位的错误识别，其中不应期是不连续的，并且可能取决于感测到的事件，预定时间间隔的期满或相同或其它室中的刺激事件 的心脏 不连续的不应期提高了器件感知内在事件的能力。 本发明包括针对每个选择的循环并入感测协议内的单独的耐火和浮动不应期，从而增加了正常感测的时间段。

公开(公告)号：US08027723B2

公开(公告)日：2011-09-27

申请号：US12109169

申请日：2008-04-24

申请人： Joseph M. Pastore ,  Julio C. Spinelli

发明人： Joseph M. Pastore ,  Julio C. Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36557 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/3702

摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.

摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

公开(公告)号：US20110137363A1

公开(公告)日：2011-06-09

申请号：US13019888

申请日：2011-02-02

申请人： Tamara Colette Baynham ,  Julio C. Spinelli ,  Frits W. Prinzen ,  Richard N. Cornelussen ,  Ward Y.R. Vanagt

发明人： Tamara Colette Baynham ,  Julio C. Spinelli ,  Frits W. Prinzen ,  Richard N. Cornelussen ,  Ward Y.R. Vanagt

IPC分类号： A61N1/365

CPC分类号： A61N1/36557 ,  A61B5/026 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3702

摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.

摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。

公开(公告)号：US07909769B2

公开(公告)日：2011-03-22

申请号：US12319740

申请日：2009-01-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Julio C. Spinelli

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/103

CPC分类号： A61B5/14539 ,  A61B5/0008 ,  A61B5/024 ,  A61B5/076 ,  A61B5/145

摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.

摘要翻译： 植入心脏监测器包括测量心力衰竭患者心脏的各个方面的传感器。 远程心脏监测系统将植入的心脏监测器连接到护理提供者，例如医师。 由植入式心脏监测器提供的数据允许护理提供者在心脏上获得有价值的数据，以便使医疗保健决定影响心力衰竭患者的治疗。 在许多情况下，核心体温和其他患者数据的测量将使护理人员能够改变患者的治疗以解决病人的状况。 植入的心脏监测器可以通过无线通信链路与外部监视器进行通信。 植入心脏监视器可以被实现为起搏装置（即，起搏器）的一部分，或者可以是专用于监视功能的单独单元。 外部监视器通过通信链路与监控站进行通信。 监控站可以作为集中数据采集单元运行，从多个外部监视器和多个植入心脏监视器收集数据。 可以监测心力衰竭患者的心脏和/或身体的各种其他方面，例如心率，血液pH值，血液二氧化碳水平以及心力衰竭患者活动的任何其他指征。 可以设置各种预定阈值以触发报警和/或数据报告。

公开(公告)号：US07894896B2

公开(公告)日：2011-02-22

申请号：US11382849

申请日：2006-05-11

申请人： Tamara Colette Baynham ,  Julio C. Spinelli ,  Frits W. Prinzen ,  Richard N. Cornelussen ,  Ward Y. R. Vanagt

发明人： Tamara Colette Baynham ,  Julio C. Spinelli ,  Frits W. Prinzen ,  Richard N. Cornelussen ,  Ward Y. R. Vanagt

IPC分类号： A61B8/14 ,  A61N1/36

CPC分类号： A61N1/36557 ,  A61B5/026 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3702

摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.

摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。

公开(公告)号：US20100286738A1

公开(公告)日：2010-11-11

申请号：US12838792

申请日：2010-07-19

申请人： Joseph M. Pastore ,  Imad Libbus ,  Andrew P. Kramer ,  Julio C. Spinelli

发明人： Joseph M. Pastore ,  Imad Libbus ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3622

摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.

摘要翻译： 用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。 高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。 高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

公开(公告)号：US07774065B2

公开(公告)日：2010-08-10

申请号：US11836502

申请日：2007-08-09

申请人： Julio C. Spinelli ,  Qingsheng Zhu

发明人： Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/371

摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

摘要翻译： 一种用于测量双极引线的捕获阈值的系统和方法，以便确定由心律管理装置与引线一起使用的刺激脉冲能量的适当值。 也可以确定适当的双极刺激构型。 该方法在测试用于激发左心室的双极引线（例如递送心脏再同步治疗时）特别有用。

公开(公告)号：US07774057B2

公开(公告)日：2010-08-10

申请号：US11220397

申请日：2005-09-06

申请人： Joseph M. Pastore ,  Jeffrey Ross ,  Tamara Colette Baynham ,  Rodney W. Salo ,  Andrew P. Kramer ,  Julio C. Spinelli

发明人： Joseph M. Pastore ,  Jeffrey Ross ,  Tamara Colette Baynham ,  Rodney W. Salo ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N1/08

CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

公开(公告)号：US07738957B2

公开(公告)日：2010-06-15

申请号：US11268284

申请日：2005-11-03

申请人： Julio C. Spinelli ,  Qingsheng Zhu ,  Jeffrey E. Stahmann ,  Andrew P. Kramer

发明人： Julio C. Spinelli ,  Qingsheng Zhu ,  Jeffrey E. Stahmann ,  Andrew P. Kramer

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。

公开(公告)号：US07664549B2

公开(公告)日：2010-02-16

申请号：US11125501

申请日：2005-05-10

申请人： Julio C. Spinelli ,  Qingsheng Zhu ,  Jeffrey E. Stahmann ,  Andrew P. Kramer

发明人： Julio C. Spinelli ,  Qingsheng Zhu ,  Jeffrey E. Stahmann ,  Andrew P. Kramer

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。