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公开(公告)号：US07962208B2
公开(公告)日：2011-06-14
申请号：US11113828
申请日：2005-04-25
申请人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/08
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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公开(公告)号：US08452400B2
公开(公告)日：2013-05-28
申请号：US13113706
申请日：2011-05-23
申请人： Allan C. Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan C. Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/06
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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公开(公告)号：US08396549B2
公开(公告)日：2013-03-12
申请号：US10834899
申请日：2004-04-28
IPC分类号： A61N1/36
CPC分类号： A61N1/0587 , A61N1/36017 , A61N1/3622
摘要： A method for pacing a left ventricle of a heart includes delivering a pacing pulse via a first electrode to activate a first papillary muscle and another pacing pulse via a second electrode to activate a second papillary muscle.
摘要翻译： 用于起搏心脏左心室的方法包括经由第一电极递送起搏脉冲以通过第二电极激活第一乳头肌和另一起搏脉冲以激活第二乳头肌。
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公开(公告)号：US20100298841A1
公开(公告)日：2010-11-25
申请号：US12778679
申请日：2010-05-12
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/36017 , A61N1/362 , A61N1/37252
摘要： A medical electrical trans-septal pacing lead includes a lead body, a tine-like structure terminating a distal end of the lead body and a distal electrode coupled to the lead body at a position proximal to and in close proximity to the structure. A method for delivering left ventricular pacing to a heart includes inserting the trans-septal pacing lead through an inter-ventricular septal wall of the heart, from a right ventricle to a left ventricle, and positioning the distal electrode in a left ventricular endocardial surface of the septal wall.
摘要翻译： 医疗电隔离起搏引线包括引线本体，终止引线主体的远端的齿状结构，以及在靠近并且非常接近结构的位置处联接到引线主体的远端电极。 用于向心脏递送左心室起搏的方法包括将跨隔间起搏引线穿过心脏的心室间隔壁，从右心室插入到左心室，并将远端电极定位在左心室心内膜的左心室心内表面 隔壁。
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5.发明申请公开(公告)号：US20110137363A1
公开(公告)日：2011-06-09
申请号：US13019888
申请日：2011-02-02
申请人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
发明人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
IPC分类号： A61N1/365
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。
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6.发明授权公开(公告)号：US07894896B2
公开(公告)日：2011-02-22
申请号：US11382849
申请日：2006-05-11
申请人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
发明人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。
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公开(公告)号：US20090043348A1
公开(公告)日：2009-02-12
申请号：US12250868
申请日：2008-10-14
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of lo depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 保护作用通过将心脏起搏装置配置为间歇地从正常操作模式切换到应变增强模式而产生，其中，lo去极化的空间模式被改变，从而使心室心肌的特定区域或区域增加机械应力 。
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8.发明授权公开(公告)号：US08396552B2
公开(公告)日：2013-03-12
申请号：US13019888
申请日：2011-02-02
申请人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
发明人： Tamara Colette Baynham , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。 起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。 在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。
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公开(公告)号：US08214040B2
公开(公告)日：2012-07-03
申请号：US12250868
申请日：2008-10-14
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20110230928A1
公开(公告)日：2011-09-22
申请号：US13113706
申请日：2011-05-23
申请人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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