公开(公告)号：US08134006B2

公开(公告)日：2012-03-13

申请号：US12701108

申请日：2010-02-05

Applicant: Pierre-Jean Colson ,  Adam D. Hughes ,  Craig Husfeld ,  Mathai Mammen ,  Miroslav Rapta

Inventor： Pierre-Jean Colson ,  Adam D. Hughes ,  Craig Husfeld ,  Mathai Mammen ,  Miroslav Rapta

IPC: C07D211/00

CPC classification number: C07D211/46

Abstract: This invention relates to compounds of formula I: wherein R1 and R2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions and combinations comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compound to, for example, treat pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明涉及式I化合物：其中R1和R2如本说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物和组合物，用于制备这些化合物的方法和中间体，以及使用该化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。

公开(公告)号：US08133905B2

公开(公告)日：2012-03-13

申请号：US12640869

申请日：2009-12-17

Applicant: YongQi Mu ,  YuHua Ji ,  Mathai Mammen ,  Viengkham Malathong

Inventor： YongQi Mu ,  YuHua Ji ,  Mathai Mammen ,  Viengkham Malathong

IPC: A61K31/45 ,  A61K31/454 ,  A61K31/4545 ,  C07D401/10 ,  C07D295/08

CPC classification number: C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，m，n，q，r，w，Z1，Ar1，Z2，Y，R1，R2和R3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20110312994A1

公开(公告)日：2011-12-22

申请号：US13011100

申请日：2011-01-21

Applicant: Mathai Mammen ,  Eric Stangeland

Inventor： Mathai Mammen ,  Eric Stangeland

IPC: A61K31/4709 ,  A61P11/08 ,  A61P11/06 ,  C07D401/12 ,  A61P11/00

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I的联苯衍生物：其中R1，R2，R3，R4，R5，R6，R7，W，a，b和c如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的联苯衍生物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

公开(公告)号：US08034946B2

公开(公告)日：2011-10-11

申请号：US12814629

申请日：2010-06-14

Applicant: Mathai Mammen ,  YuHua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  YuHua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: C07D211/00

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US08008278B2

公开(公告)日：2011-08-30

申请号：US12891459

申请日：2010-09-27

Applicant: Mathai Mammen ,  Adam Hughes

Inventor： Mathai Mammen ,  Adam Hughes

IPC: A01N55/00 ,  A01N43/36 ,  A61K31/47 ,  C07D403/00 ,  C07D253/00

CPC classification number: C07D401/12 ,  C07D207/04 ,  C07D207/09 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14

Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，Ar 1，Ar 2，E，a，b，c和z如说明书中所定义，或其药学上可接受的盐或溶剂合物 或其立体异构体。 本发明的化合物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这些化合物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

公开(公告)号：US20100331375A1

公开(公告)日：2010-12-30

申请号：US12880752

申请日：2010-09-13

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

IPC: A61K31/4439 ,  C07D401/12 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08

CPC classification number: C07D211/62 ,  C07D409/14

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，Ar1，R1，R2，R3，R4，R6，R7，R8和W如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07838535B2

公开(公告)日：2010-11-23

申请号：US12001363

申请日：2007-12-11

Applicant: Mathai Mammen ,  Sarah Dunham

Inventor： Mathai Mammen ,  Sarah Dunham

IPC: A61K31/445

CPC classification number: C07D417/12 ,  A61K31/439 ,  A61K31/445 ,  A61K31/4545 ,  C07D277/68

Abstract: The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US07816532B2

公开(公告)日：2010-10-19

申请号：US12328033

申请日：2008-12-04

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

IPC: C07D211/40 ,  A61K31/445

CPC classification number: C07D211/62 ,  C07D409/14

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，Ar1，R1，R2，R3，R4，R6，R7，R8和W如 规范。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07732441B2

公开(公告)日：2010-06-08

申请号：US12069168

申请日：2008-02-07

Applicant: Mathai Mammen ,  Adam Hughes

Inventor： Mathai Mammen ,  Adam Hughes

IPC: A61K31/44 ,  A61K31/54 ,  C07D221/22 ,  C07D45/02 ,  C07D417/00

CPC classification number: C07D451/02 ,  A61K31/46 ,  A61K31/4743 ,  C07D451/12 ,  C07D471/08

Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 这些化合物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

公开(公告)号：US20100093753A1

公开(公告)日：2010-04-15

申请号：US12640869

申请日：2009-12-17

Applicant: YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Viengkham Malathong

Inventor： YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Viengkham Malathong

IPC: A61K31/45 ,  C07D211/44 ,  C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61P11/00

CPC classification number: C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.