公开(公告)号：US20210070869A1

公开(公告)日：2021-03-11

申请号：US17046199

申请日：2019-04-10

Applicant: GENMAB A/S

Inventor： Maarten JANMAAT ,  Esther BREIJ ,  Ulf FORSSMANN ,  Tahamtan AHMADI ,  Julia BOSHUIZEN ,  Daniel PEEPER ,  Nora PENCHEVA

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: The disclosure relates to anti-AXL antibodies, immunoconjugates, and compositions for treatment of cancer, which is resistant to or is predicted to be or become resistant to treatment with a programmed cell death-1/programmed cell death-1 ligand (PD-1/PD-L1) inhibitor.

公开(公告)号：US20210061919A1

公开(公告)日：2021-03-04

申请号：US16947021

申请日：2020-07-15

Applicant: GENMAB A/S

Inventor： Jan VAN DE WINKEL ,  Tom VINK ,  Janine SCHUURMAN ,  Paul PARREN ,  Rob AALBERSE ,  Marijn VAN DER NEUT KOLFSCHOTEN

IPC: C07K16/28 ,  A61K51/10 ,  C07K16/00 ,  A61K47/68 ,  C07K16/16 ,  C07K16/18

Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

公开(公告)号：US10927181B2

公开(公告)日：2021-02-23

申请号：US16582534

申请日：2019-09-25

Applicant: BIONTECH SE ,  GENMAB A/S

Inventor： Ugur Sahin ,  Friederike Gieseke ,  Isil Altintas ,  David Satijn ,  Paul Parren

IPC: C07K16/28

Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.

公开(公告)号：US20200317799A1

公开(公告)日：2020-10-08

申请号：US16689361

申请日：2019-11-20

Applicant: Genmab A/S

Inventor： Jessica Teeling ,  Sigrid Ruuls ,  Martin Glennie ,  Jan G.J. van de Winkel ,  Paul Parren ,  Jørgen Petersen ,  Ole Baadsgaard ,  Haichun Huang

IPC: C07K16/28 ,  C07K16/42 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US20200262932A1

公开(公告)日：2020-08-20

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46 ,  G01N33/68 ,  C07K16/40 ,  C07K16/32 ,  C07K16/28 ,  C07K16/10

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

公开(公告)号：US20200246477A1

公开(公告)日：2020-08-06

申请号：US16742158

申请日：2020-01-14

Applicant: GENMAB A/S

Inventor： Jesper VALBJØRN ,  Xiaona JING ,  Kelly Ann ROBY ,  Timothy Warren PAUL ,  Gregory Allan SACHA ,  Nathan Alan PEASE ,  Bodil WILLUMSEN

IPC: A61K47/68 ,  A61K9/19 ,  A61K39/395 ,  A61K47/22 ,  C07K16/36 ,  A61K47/26 ,  A61K47/18

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

公开(公告)号：US10512688B2

公开(公告)日：2019-12-24

申请号：US15325364

申请日：2015-07-10

Applicant: GENMAB A/S

Inventor： Esther Breij ,  David Satijn ,  Edward Norbert Van Den Brink ,  Dennis Verzijl ,  Rob N. De Jong ,  Paul Parren ,  Riemke Van Dijkhuizen Radersma

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00 ,  C07K16/30

Abstract: The present disclosure relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.

公开(公告)号：US20190284278A1

公开(公告)日：2019-09-19

申请号：US15744317

申请日：2016-07-14

Applicant: GENMAB A/S

Inventor： Rik RADEMAKER ,  Isil ALTINTAS ,  Patrick ENGELBERTS ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

公开(公告)号：US20180326084A1

公开(公告)日：2018-11-15

申请号：US15742818

申请日：2016-07-08

Applicant: GENMAB A/S

Inventor： Julia BOSHUIZEN ,  Kirstine JACOBSEN ,  Esther BREIJ ,  Louise KOOPMAN ,  David SATIJN ,  Edward VAN DEN BRINK ,  Dennis VERZIJL ,  Rob DE JONG ,  Riemke VAN DIJKHUIZEN RADERSMA ,  Daniel PEEPER ,  Henrik Jørn DITZEL ,  Paul PARREN

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00

CPC classification number: A61K47/6803 ,  A61K39/001102 ,  A61K45/06 ,  A61K47/6801 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6869 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2863 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of resistant or refractory cancers.

公开(公告)号：US20180194849A1

公开(公告)日：2018-07-12

申请号：US15538419

申请日：2016-01-08

Applicant: BIONTECH AG ,  GENMAB A/S

Inventor： Ugur Sahin ,  Friederike Gieseke ,  Isil Altintas ,  David Satijn ,  Paul Parren

IPC: C07K16/28

Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.