公开(公告)号：US10519423B1

公开(公告)日：2019-12-31

申请号：US15853095

申请日：2017-12-22

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Kunhua Song ,  Yuanbiao Zhao ,  Pilar Londono ,  Timothy McKinsey

IPC: A61K48/00 ,  A61K38/17 ,  C12N5/077 ,  A61K45/06 ,  A61K31/713

Abstract: Pro-fibrotic signaling potently antagonizes cardiac reprogramming. Inhibition of pro-fibrotic signaling using small molecules that target the transforming growth factor-β/SMAD, or Rho kinase leads to conversion of approximately 60% of fibroblasts into beating cardiomyocytes. Conversely, over-activation of these pro-fibrotic signaling networks inhibits cardiac reprogramming. Using the disclosed methods, fibroblasts are converted to spontaneously contracting cardiomyocytes in less than two weeks.

公开(公告)号：US20190385697A1

公开(公告)日：2019-12-19

申请号：US16485717

申请日：2018-02-14

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： Robin DOWELL-DEEN ,  Joseph AZOFEIFA ,  Mary A. ALLEN

IPC: G16B20/30 ,  G01N33/50 ,  C12Q1/6869 ,  G16B40/10 ,  G16B50/30 ,  G06F17/18

Abstract: Provided herein are methods for approximating transcription factor (TF) activity in a cell. The methods can approximate changes in TF activity resulting from a stimulus, such as a drug or cell differentiation. Some methods for approximating TF activity in a cell are laboratory methods. Some methods may be used to identify diagnostic signatures of transcription factor activity, and identify cell type or disease state. Computer-based systems for evaluating the effect of a stimulus on TF activity in a cell are also provided.

公开(公告)号：US20190380968A1

公开(公告)日：2019-12-19

申请号：US16448647

申请日：2019-06-21

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Kimberly Hassett ,  Pradyot Nandi ,  John Carpenter ,  Theodore Randolph

IPC: A61K9/19 ,  A61K39/39 ,  A61K39/00 ,  A61K47/26

Abstract: The present invention relates generally to the field of immunogenic compositions containing volatile salts. In certain embodiments, compositions and methods disclosed herein relate to producing and using novel combinations to create frozen immunogenic agents bound to adjuvant having improved formulations and improved consistency of distribution of adjuvant for storage and subsequent delivery to a subject in need thereof.

公开(公告)号：US10463534B2

公开(公告)日：2019-11-05

申请号：US14894299

申请日：2014-05-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Malik Y. Kahook ,  Matthew Armstrong Powers

IPC: A61F9/007

Abstract: The present invention relates generally to the field of cataract surgery and more particularly to methods and apparatus for performing a capsulorhexis. This invention is in the field of medical devices. The present invention relates to a device constructed from metals, polymers or other materials that are amenable to precise surface modifications and methods for its use, wherein (1) the device assists in capsulorhexis and (2) a patterned surface having milli-, micron-, and/or nano-sized micropatterning characteristics that imparts surface stabilizing and self-adhesive properties.

公开(公告)号：US20190321448A1

公开(公告)日：2019-10-24

申请号：US16451188

申请日：2019-06-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Aaron Michels ,  Peter A. Gottlieb

IPC: A61K38/28 ,  G01N33/50 ,  C07K14/62

Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.

公开(公告)号：US20190310379A1

公开(公告)日：2019-10-10

申请号：US16375458

申请日：2019-04-04

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Dennis M. Akos ,  Nagaraj Channarayapatna Shivaramaiah ,  Yafeng Li

IPC: G01S19/32 ,  H01Q5/50

Abstract: Various embodiments of the present technology generally relate to Global Navigation Satellite Systems (GNSS). More specifically, the embodiments of the present technology relate to a smart antenna module resistant to RFI saturation for dual-frequency GNSS receivers. In some embodiments, a dynamically configured antenna module architecture can be for a dual-band (or multi-frequency) GNSS receiver that can adapt to different RFI conditions by performing corresponding working modes. For example, some embodiments of the smart antenna can measure (e.g., using a power detector) the power of an incoming multi-frequency signal to determine when the multifrequency signal is saturated. Then, using control logic the smart antenna can determine which frequency in the multi-frequency signal is usable and isolate (e.g. using radio frequency components) a frequency that is not saturated. A position estimate can then be generated based on the isolated multi-frequency signal.

公开(公告)号：US10435715B2

公开(公告)日：2019-10-08

申请号：US16275439

申请日：2019-02-14

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Ryan T. Gill ,  Andrew Garst

IPC: C12N15/90 ,  C12N15/10 ,  C12N15/11 ,  C12N9/22 ,  C40B40/08

Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.

公开(公告)号：US20190298811A1

公开(公告)日：2019-10-03

申请号：US16316018

申请日：2017-07-05

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jesse DAVIDSON

IPC: A61K38/46 ,  A61P7/04

Abstract: The present invention includes a method of inhibiting and/or reducing blood coagulation in a subject. The present invention further provides a method of treating and/or preventing inflammation and/or organ dysfunction in a subject.

公开(公告)号：US10428185B2

公开(公告)日：2019-10-01

申请号：US15539312

申请日：2016-12-05

Applicant: Colorado State University Research Foundation ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Travis S. Bailey ,  Chen Guo ,  Jackson T. Lewis ,  Kristine Fischenich ,  Tammy Haut Donahue ,  Dilanji Wijayasekara ,  Matthew G. Cowan ,  Douglas L. Gin ,  Richard D. Noble

IPC: C08J3/075 ,  B01D69/02 ,  B01D71/80 ,  B01J13/00 ,  C08L53/00 ,  H01M2/16 ,  B01D71/76 ,  B01D71/28 ,  B01D71/52

Abstract: Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

公开(公告)号：US10423736B2

公开(公告)日：2019-09-24

申请号：US15247720

申请日：2016-08-25

Applicant: The University of British Columbia ,  The Regents of the University of Colorado, a body corporate

Inventor： John Grace ,  Amir Hossein Ahmadi-Motlagh ,  Martha Salcudean ,  Christine Hrenya

IPC: G06F17/50

Abstract: A computer implemented method simulates the behavior of a gas-solid mixture in a fluidized bed having a particulate comprising Geldart group A particles using a Eulerian model comprising, for each time step (a current time step) and for each cell: obtaining an initial value of an agglomerate diameter corresponding to the cell and corresponding to the beginning of the current time step; performing a force-balance procedure for the cell to determine a first agglomerate diameter corresponding to the cell and corresponding to the current time step, wherein performing the force-balance procedure comprises determining a plurality of forces for the cell based at least in part on the initial value of the agglomerate diameter; updating one or more drag relationships for the current time step based at least in part on the first agglomerate diameter; and performing a computational fluid dynamic (CFD) solve procedure to determine, for the current time, the any one or more of: one or more of: a gas velocity {right arrow over (V)}g for the cell, a particle velocity {right arrow over (V)}s for the cell, a gas pressure for the cell, a particulate pressure for the cell and a solid fraction εs for the cell. Performing the CFD solve procedure is based at least in part on the updated drag relationships.