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公开(公告)号：US20100087386A1
公开(公告)日：2010-04-08
申请号：US12574666
申请日：2009-10-06
IPC分类号： A61K31/5383 , A61P29/00 , A61K31/7036
CPC分类号： A61K45/06 , A61K31/536 , A61K31/5383 , A61K31/7036 , A61K33/06 , A61K47/02 , C07D498/14 , A61K2300/00
摘要： The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.
摘要翻译： 本发明涉及用于治疗肺部炎症的方法和组合物。 特别地，提供了使用气溶胶左氧氟沙星或氧氟沙星来减少肺部炎症的方法和组合物。
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公开(公告)号：US20140105985A1
公开(公告)日：2014-04-17
申请号：US14134348
申请日：2013-12-19
IPC分类号： A61K31/5383 , A61K45/06 , A61K47/02
CPC分类号： A61K45/06 , A61K31/536 , A61K31/5383 , A61K31/7036 , A61K33/06 , A61K47/02 , C07D498/14 , A61K2300/00
摘要： The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.
摘要翻译： 本发明涉及用于治疗肺部炎症的方法和组合物。 特别地，提供了使用气溶胶左氧氟沙星或氧氟沙星来减少肺部炎症的方法和组合物。
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13.发明申请QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF 失效季铵盐氨基脲类止痛剂抑制剂及其治疗用途公开(公告)号：US20120165276A1
公开(公告)日：2012-06-28
申请号：US12116164
申请日：2008-05-06
IPC分类号： A61K38/06 , C07D265/16 , A61K31/421 , C07C237/22 , A61P31/04 , A61K31/7056 , C07K5/09 , C07K5/083 , A61K31/536 , A61K38/05 , A61K31/65 , A61K31/7008 , C07K5/068 , A61K38/02
CPC分类号： C07D215/38 , C07C237/22 , C07D277/82 , C07K5/06086
摘要： Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
摘要翻译： 公开了具有至少一个季烷基铵官能团的化合物。 该化合物抑制细菌外排泵抑制剂，并与抗菌剂组合使用以治疗或预防细菌感染。 这些组合可以有效地抵抗通过外排泵机制对抗细菌剂产生抗性的细菌感染。
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公开(公告)号：US07947741B2
公开(公告)日：2011-05-24
申请号：US11082745
申请日：2005-03-16
申请人： Keith Bostian , Tomasz Glinka , Olga Lomovskaya , Mark Surber
发明人： Keith Bostian , Tomasz Glinka , Olga Lomovskaya , Mark Surber
IPC分类号： A01N37/52 , A61K31/155
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/421 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial, and novel medical methods.
摘要翻译： 本发明提供了与抗微生物剂共同施用的外排泵抑制剂，用于治疗由耐药性病原体引起的感染，新型外排泵抑制剂，具有抗微生物剂的外排泵抑制剂的组合剂型和新颖的医学方法。
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公开(公告)号：US20100158957A1
公开(公告)日：2010-06-24
申请号：US12695981
申请日：2010-01-28
IPC分类号： A61K9/00 , A61K31/5383 , A61K31/496 , A61K31/4375 , A61P31/04
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
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公开(公告)号：US20100040560A1
公开(公告)日：2010-02-18
申请号：US12604324
申请日：2009-10-22
IPC分类号： A61K9/12
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
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公开(公告)号：US20100037890A1
公开(公告)日：2010-02-18
申请号：US12604347
申请日：2009-10-22
申请人： Mark W. Surber , Keith A. Bostian , Michael N. Dudley , Olga Lomovskaya (AKA Olga Rodny) , David C. Griffith
发明人： Mark W. Surber , Keith A. Bostian , Michael N. Dudley , Olga Lomovskaya (AKA Olga Rodny) , David C. Griffith
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
摘要翻译： 本文公开了适用于气雾化和使用这种制剂的氟喹诺酮类制剂用于气雾剂施用氟喹诺酮抗微生物剂以治疗肺细菌感染。 特别地，描述了专门配制并递送用于肺细菌感染的吸入性左氧氟沙星。 方法包括用于生产和使用所述组合物的吸入方案和制造方法。
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公开(公告)号：US08546423B2
公开(公告)日：2013-10-01
申请号：US12604340
申请日：2009-10-22
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4412 , A61K33/00 , A61K33/14 , A61K33/26 , A61K33/30 , A01N25/00 , A01N25/02 , A01N25/06 , A01N59/08
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
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公开(公告)号：US08357696B2
公开(公告)日：2013-01-22
申请号：US12695981
申请日：2010-01-28
IPC分类号： A61K9/14 , A61K31/00 , A61K31/44 , A61K31/4412 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A01N25/00 , A01N25/02 , A01N25/06 , A01N59/08
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/5123 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
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20.发明申请公开(公告)号：US20120276153A1
公开(公告)日：2012-11-01
申请号：US13412423
申请日：2012-03-05
申请人： Jeffery S. Loutit , Elizabeth E. Morgan , Michael N. Dudley , David C. Griffith , Olga Lomovskaya
发明人： Jeffery S. Loutit , Elizabeth E. Morgan , Michael N. Dudley , David C. Griffith , Olga Lomovskaya
CPC分类号： A61K31/5383 , A61K9/0078 , A61K9/08 , A61K33/06 , A61K33/14 , A61K45/06 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
摘要翻译： 囊性纤维化的治疗方法 该方法包括向有需要的人施用包含左氧氟沙星或氧氟沙星和二价或三价阳离子的气溶胶溶液。 更具体地，该方法包括将气溶胶溶液施用于包含铜绿假单胞菌的肺部感染的人。
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