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公开(公告)号：US11306084B2
公开(公告)日：2022-04-19
申请号：US16474505
申请日：2017-12-28
IPC分类号： C07D471/04 , A61K9/00
摘要： The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβι and/or α5βι. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.
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12.发明授权公开(公告)号：US11191754B2
公开(公告)日：2021-12-07
申请号：US16533204
申请日：2019-08-06
IPC分类号： A61K31/4412 , C07D213/89 , A61P31/12 , C12N9/22 , A61P31/22 , A61K9/00 , A61K31/122 , A61K31/4375 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/662 , A61K31/675 , A61K31/7072 , A61K31/7076 , A61K38/21 , C07C50/28 , C07D471/04
摘要： The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
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公开(公告)号：US20210284638A1
公开(公告)日：2021-09-16
申请号：US17257432
申请日：2019-06-27
IPC分类号： C07D471/04
摘要： The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβ1 and/or α5β1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.
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公开(公告)号：US20210260172A1
公开(公告)日：2021-08-26
申请号：US17314510
申请日：2021-05-07
发明人： Adriana M. Montaño-Suarez , Angela Catalina Sosa-Molano , Alan Knutsen , Clifford Bellone , Shunji Tomatsu , Luis Barrera
摘要： Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS.
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公开(公告)号：US20210147378A1
公开(公告)日：2021-05-20
申请号：US17046885
申请日：2019-04-10
IPC分类号： C07D333/76 , A61K41/00 , A61P35/00 , A61K45/06
摘要： In one aspect, the present disclosure provides a compound of the formula: In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
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公开(公告)号：US20200346183A1
公开(公告)日：2020-11-05
申请号：US16863109
申请日：2020-04-30
IPC分类号： B01J19/12 , C07D345/00 , C01B13/02
摘要： The present invention generally relates to various polycyclic aromatic selenoxide compounds, methods for preparing these compounds, and methods of us these and other compounds to generate ground state atomic oxygen.
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公开(公告)号：US10821164B2
公开(公告)日：2020-11-03
申请号：US15738209
申请日：2016-06-06
发明人： Daniel Hoft , Chris Eickhoff , Annie De Groot
摘要： The present disclosure relates to vaccine formulations and their use in treating and preventing Chagas Disease.
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公开(公告)号：US10801018B2
公开(公告)日：2020-10-13
申请号：US16599730
申请日：2019-10-11
摘要： Disclosed are methods and compositions for reduced immunogenic proteins used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are genetically engineered variants of N-acetylgalactosamine-6-sulfatase (GALNS), which are less immunogenetic then wild-type GALNS, but maintain enzymatic activity, and may be used to treat Mucopolysaccharidosis IVA (Morquio A disease, MPS IVA).
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公开(公告)号：US20200297696A1
公开(公告)日：2020-09-24
申请号：US16766030
申请日：2018-11-16
发明人： Francis M. SVERDRUP , Stephen J. TAPSCOTT , Jonathan OLIVA , Amy E. CAMPBELL , Marvin J. MEYERS
IPC分类号： A61K31/415 , A61K9/00 , A61K31/495 , A61K31/506 , A61K31/437 , A61K31/519 , A61K31/44 , A61K31/5513 , A61K31/4412 , A61K31/4439 , A61K31/496 , A61K31/5025 , A61P21/00
摘要： The present disclosure provides methods of treating a patient comprising administering a p38 inhibitor for the treatment of FSHD. In some embodiments, the present methods comprise using one or more p38 inhibitors as a therapeutic agent for the treatment of FSHD patients including patients who are being treated with one or more palliative treatments such as therapy and/or agents which lead to increased muscle mass.
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公开(公告)号：US10766832B1
公开(公告)日：2020-09-08
申请号：US16004098
申请日：2018-06-08
发明人： Jacob M Laktas , Ian D Stochl , Gregory J Place , Paul Jelliss , Stephen Chung , Steven W Buckner
摘要： The present invention generally concerns a nano-enhanced explosive that is integrated at many points across an explosive train. More specifically, a nano-enhanced explosive is formed when a nanocomposite we call nMx is combined with a secondary high explosive. nMx is made of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer having unique burning profiles that lend energy to the explosive process including increased shockwave propagation through a chemical explosive and increased temperatures and gaseous pressure build up and release in and about the same. Our nano-enhanced explosive can be integrated at various points across an explosive train, e.g. use within a detonation cord (fuse), or as a detonation charge (initiator), or as the main charge, where the use of the nano-enhanced explosive can be characterized by the energy lent to projectiles from munitions, bubbles formed by underwater explosive trains, or blast profiles.
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