公开(公告)号：US20120190738A1

公开(公告)日：2012-07-26

申请号：US13144263

申请日：2010-01-12

Applicant: Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

Inventor： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC: A61K31/36 ,  A61K31/225 ,  C07C215/54 ,  A61K31/138 ,  C07C255/33 ,  A61P35/02 ,  A61K31/15 ,  C07D317/50 ,  C07C39/10 ,  A61K31/05 ,  A61P35/00 ,  C07C69/353 ,  A61K31/277

CPC classification number: C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

Abstract: The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

Abstract translation: 本发明涉及通过抑制PI3-Akt途径或诱导NO而治疗恶性肿瘤的通式I化合物。 本发明还涉及通式I的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US20050153000A1

公开(公告)日：2005-07-14

申请号：US10809645

申请日：2004-03-25

Applicant: Debleena Dey ,  Swapan Mandal ,  Mohua Mukherjee ,  Bikash Pal ,  Tanushree Biswas ,  Malabika Datta ,  Sib Roy ,  Arun Bandyopadhyay ,  Samir Bhattacharya ,  B. Giri ,  Santu Bandopadhyay ,  Aditya Konar

Inventor： Debleena Dey ,  Swapan Mandal ,  Mohua Mukherjee ,  Bikash Pal ,  Tanushree Biswas ,  Malabika Datta ,  Sib Roy ,  Arun Bandyopadhyay ,  Samir Bhattacharya ,  B. Giri ,  Santu Bandopadhyay ,  Aditya Konar

IPC: A61K31/70 ,  A61K36/488 ,  A61K35/78

CPC classification number: A61K31/70 ,  A61K36/488 ,  Y10S514/866

Abstract: The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.

Abstract translation: 本发明涉及预防和/或治疗糖尿病2型的方法，还涉及增加Glut4磷酸化和Glut4易位到靶细胞膜以增强信号转导途径中的胰岛素信号的方法; 此外，本发明涉及一种简单且便宜的获得提取物的方法，其后选择性地，其活性正丁醇级分和活性分子Lupinoside PA（LPA 4 S）可用于预防和/或治疗糖尿病2型 ; 最后是其药物组合物。