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11.发明授权公开(公告)号：US07049479B2
公开(公告)日：2006-05-23
申请号：US10625327
申请日：2003-07-23
IPC分类号： A61F13/00
CPC分类号： A61L15/48 , A61F13/0213 , A61F13/0226 , A61F13/023 , A61F13/0259 , A61F2013/00804 , A61F2013/00817 , A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/602
摘要： An ultra thin film transdermal, dermal, transmucosal, mucosal pharmaceutical delivery system is disclosed, which has a handle adhered by a first adhesive to an ultra thin film layer. The opposite side of the ultra thin film is coated with a second adhesive layer, and carries an active ingredient. The handle adheres firmly to the ultra thin film layer, but does not adhere to skin, mucosa, or the silicone coated surface of a release liner. A portion of the handle extends beyond an edge of the ultra thin film to facilitate separation of the film from the release liner, and handling thereof. The second adhesive is more aggressive with respect to the patient's skin than the first adhesive is with respect to the surface of the ultra thin film, whereby the handle can be peeled away from the ultra thin film after the film has been applied to the patient.
摘要翻译： 公开了一种超薄膜透皮，真皮，经粘膜，粘膜药物递送系统，其具有通过第一粘合剂粘附到超薄膜层的手柄。 超薄膜的相反侧涂有第二粘合剂层，并带有活性成分。 手柄牢固地粘附到超薄膜层，但不粘附到皮肤，粘膜或剥离衬垫的硅氧烷涂覆的表面上。 手柄的一部分延伸超出超薄膜的边缘，以便于膜与剥离衬垫的分离及其处理。 相对于第一粘合剂相对于超薄膜的表面，第二粘合剂相对于患者的皮肤更具攻击性，从而在膜施加到患者之后手柄可以从超薄膜剥离。
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公开(公告)号：US5153040A
公开(公告)日：1992-10-06
申请号：US383229
申请日：1989-07-19
CPC分类号： A61L15/26 , A61F13/023 , A61L15/58 , A61F2013/00812 , A61F2013/00817 , A61F2013/00868 , A61F2013/00897 , A61F2013/00982 , Y10T428/1462 , Y10T428/24273 , Y10T428/24281 , Y10T428/24322 , Y10T428/24777 , Y10T428/28 , Y10T428/2839 , Y10T428/2848
摘要： A wound dressing includes a transparent vapor and gas permeable polymeric film which has an adhesive coated surface. A pair of liners or release sheets cover the adhesive coated surface and the liners define overlapping gripping flaps. Additional adhesive strips are positioned at opposed edges of the film and interposed between the adhesive coated surface of the film and the liners. Increased adhesion of the film to the liners occurs at the adhesive strips. The film is perforated adjacent the adhesive strips.
摘要翻译： 伤口敷料包括具有粘合剂涂覆表面的透明蒸汽和透气聚合物膜。 一对衬垫或剥离片覆盖粘合剂涂覆表面，并且衬垫限定重叠的夹紧片。 另外的粘合剂条被定位在膜的相对边缘处，并且介于膜的粘合剂涂覆表面和衬垫之间。 在粘合剂条上发生膜对衬垫的增加的附着力。 胶片在胶带附近穿孔。
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公开(公告)号：US4556441A
公开(公告)日：1985-12-03
申请号：US460582
申请日：1983-01-24
CPC分类号： B32B38/10 , A61M35/00 , A61F2013/0296 , A61K9/7023 , B32B2037/268 , B32B2309/68 , B32B37/0053 , B32B37/226 , B32B38/0004 , Y10S602/90 , Y10T156/1062 , Y10T156/1075 , Y10T156/1077 , Y10T156/108 , Y10T156/1082
摘要： A machine and method for making base assemblies for medicine dispensing compresses, includes using a web of substantially imperforate material, and a web of backing material having a base layer with an adhesive on one side to attach the compress to the skin of the user. A plurality of individual foil lids or dam patches are cut from the web of imperforate material, and applied to the adhesive side of the base layer. A release or cover layer is applied to the adhesive side of the base layer to sandwich the dam patches between the base layer and the cover layer. Individual base units are cut into the base layer, with one of the dam patches positioned within each of the base units. Apertures are cut in the areas of the cover layer overlying the dam patches to access a portion of the foil surface of each of the dam patches. The offal portion of the base layer is removed from the cover layer, forming fabricated base assemblies for the compresses, which are conveniently carried together on the cover layer for final assembly. The dam patch cutting and applying steps may include roller die cutting the web of imperforate material, separating the dam patches from the offal portion by a vacuum operated applicator drum, and pressing the cut dam patches into contact with the adhesive side of the base layer. For final assembly of the compresses, a medicine-filled pad is positioned on each of the dam patches, and an imperforate, removable outer sheet is applied over each of the medicine-filled pads to form sealed reservoirs in which the medicine-filled pads are retained.
摘要翻译： 一种用于制造用于药物分配压缩物的基座组件的机器和方法，包括使用基本上无孔材料的腹板以及具有在一侧上具有粘合剂的基底层的背衬材料腹板以将压缩物附接到使用者的皮肤。 从无孔材料的纤维网上切割出多个单独的箔盖或坝贴，并施加到基层的粘合剂侧。 将释放层或覆盖层施加到基层的粘合剂侧以将堤坝夹在基层和覆盖层之间。 单个基本单元被切割成基层，其中一个坝块位于每个基本单元内。 在覆盖层的覆盖层的区域中切割孔径，以覆盖每个坝区块的箔表面的一部分。 基底层的内底部分从覆盖层移除，形成用于压缩物的制造的基座组件，这些基座组件方便地携带在覆盖层上用于最终组装。 大坝补片切割和施加步骤可以包括辊模切割无孔材料的网，通过真空操作的施加器鼓将污垢块从内部部分分离，并且将切割的坝块按压与基层的粘合剂侧接触。 为了最终组装压缩物，将药物填充垫定位在每个坝块上，并且将无孔的可移除的外片施加在每个药物填充的垫上，以形成密封的储存器，其中药物填充的垫是 保留。
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