公开(公告)号：US20240337051A1

公开(公告)日：2024-10-10

申请号：US18627732

申请日：2024-04-05

申请人： Berry Global, Inc.

发明人： Ralph A. Moody, III ,  Mehmet Selcuk Sinangil ,  James Ernest Sparks ,  Michael Wade Hayes ,  Christopher Bradley Walter ,  Sergio Rafael Diaz de Leon Izquierdo

IPC分类号： D04H1/4291 ,  A61F13/15 ,  A61F13/494 ,  A61L15/26 ,  A61L15/42 ,  D01F1/10 ,  D01F6/06 ,  D04H1/4374 ,  D04H1/4382 ,  D04H1/56 ,  D04H3/16

CPC分类号： D04H1/4291 ,  A61F13/49413 ,  A61L15/26 ,  A61L15/42 ,  D01F1/10 ,  D01F6/06 ,  D04H1/4374 ,  D04H1/43838 ,  D04H1/56 ,  D04H3/16 ,  A61F2013/15292 ,  A61F2013/15959 ,  A61F2013/15967 ,  D10B2321/022 ,  D10B2401/063 ,  D10B2509/026

摘要： Nonwoven fabrics are provided that include a first nonwoven layer comprising a first plurality of fine fibers. The first plurality of fine fibers comprises a first polymeric material including (i) a first polymer component and (ii) optionally one or more first additives, wherein the first polymer component comprises a first recycled-polypropylene (rPP) comprising a visbroken spunbond grade polypropylene having a first melt flow rate (MFR) before visbreaking and second MFR after visbreaking, and wherein the second MFR is larger than the first MFR.

公开(公告)号：US12109334B2

公开(公告)日：2024-10-08

申请号：US18159412

申请日：2023-01-25

申请人： Washington University

发明人： Matthew R. MacEwan

IPC分类号： A61L27/18 ,  A61F13/02 ,  A61L15/26 ,  A61L15/44 ,  A61L15/64 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L31/04 ,  B29C48/18 ,  B32B5/02 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  D01D5/00 ,  D04H1/728 ,  D04H3/16

CPC分类号： A61L31/04 ,  A61L15/26 ,  A61L15/44 ,  A61L15/64 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  B29C48/18 ,  B32B5/022 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  D01D5/0007 ,  D01D5/0038 ,  D01D5/0061 ,  D01D5/0076 ,  D04H1/728 ,  D04H3/16 ,  A61F13/02 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61L2430/32 ,  B32B2250/20 ,  B32B2262/0276 ,  B32B2307/518 ,  B32B2307/54 ,  B32B2307/726 ,  B32B2307/7265 ,  B32B2556/00 ,  D10B2509/00 ,  A61L15/26 ,  C08L67/04 ,  A61L27/18 ,  C08L67/04

摘要： A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

公开(公告)号：US12102516B2

公开(公告)日：2024-10-01

申请号：US16982810

申请日：2018-03-22

申请人： Kimberly-Clark Worldwide, Inc.

发明人： Jin Chen ,  Xuedong Song ,  William Clayton Bunyard ,  Andrew M. Long

IPC分类号： A61F13/537 ,  A61F13/15 ,  A61F13/47 ,  A61F13/49 ,  A61L15/26 ,  A61L15/42

CPC分类号： A61F13/537 ,  A61F13/15577 ,  A61F13/47 ,  A61F13/49007 ,  A61L15/26 ,  A61L15/425 ,  A61F2013/53773

摘要： A disposable absorbent product includes a double-network polymer element including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the element has a moisture level less than or equal to 15 percent of the total weight of the element, wherein the element comprises a latent retractive force, and wherein the element is configured to release the retractive force to achieve a dimensional change in the disposable absorbent product with exposure of the element to an aqueous liquid. Manufacturing a disposable absorbent product includes producing a double-network hydrogel; elongating by force and dehydrating while still elongated the double-network hydrogel, wherein elongating and dehydrating captures a latent retractive force in the element; and positioning the element in a disposable absorbent product such that a dimensional change in the disposable absorbent product is achieved with exposure of the element to an aqueous liquid.

公开(公告)号：US12083232B2

公开(公告)日：2024-09-10

申请号：US16630402

申请日：2018-07-12

申请人： Smith & Nephew PLC

发明人： Anthony Dagger ,  Helene Anne Lecomte

IPC分类号： A61F13/00 ,  A61F13/01 ,  A61F13/05 ,  A61L15/18 ,  A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L15/46 ,  A61L15/60 ,  A61F13/0206 ,  A61M1/00

CPC分类号： A61L15/225 ,  A61F13/00063 ,  A61F13/01012 ,  A61F13/01017 ,  A61F13/01042 ,  A61F13/05 ,  A61L15/18 ,  A61L15/26 ,  A61L15/28 ,  A61L15/46 ,  A61L15/60 ,  A61F13/0209 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/108 ,  A61L2300/404 ,  A61M1/79

摘要： Material comprising a flexible porous hydrophilic polymer foam or fibre matrix comprising two matrix faces and therebetween a structural matrix framework defining a network of cells, having a cell network surface and therein a network of pores and a powder charge comprising antimicrobial additive and/or wound dressing additive, wherein the powder charge is comprised at the matrix face or faces and/or within the cell network or within the structural matrix framework and wherein the additive is micronized, a method for the preparation thereof comprising micronizing the additive and dosing powder charge to the matrix or a reactive phase for the manufacture of said matrix, devices comprising the material and uses thereof.

公开(公告)号：US12042358B2

公开(公告)日：2024-07-23

申请号：US18197899

申请日：2023-05-16

申请人： Medline Industries, LP

发明人： Martin Coffey ,  Ramon Verduzco

IPC分类号： A61F13/00 ,  A61L15/18 ,  A61L15/26 ,  A61L15/46

CPC分类号： A61F13/00063 ,  A61F13/00991 ,  A61L15/18 ,  A61L15/26 ,  A61L15/46 ,  A61L2300/102 ,  A61L15/26 ,  C08L71/02

摘要： Disclosed is a wound dressing material comprising a substrate, about 2.5% to about 8% by weight of a bicarbonate, and a film-forming agent, the film-forming agent serving as a binder for said bicarbonate to said substrate, the film-forming agent and the bicarbonate being present in a ratio of between 1:2 and 2:1 with respect to one another. Also disclosed are a method for preparing a wound dressing material and a method for treating a wound.

公开(公告)号：US11986561B2

公开(公告)日：2024-05-21

申请号：US17499221

申请日：2021-10-12

申请人： THE PENN STATE RESEARCH FOUNDATION ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jian Yang ,  Kytai T. Nguyen ,  Zhiwei Xie

IPC分类号： A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L31/04 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  C08L67/04

CPC分类号： A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/425 ,  A61L15/44 ,  A61L15/64 ,  A61L31/042 ,  A61L31/06 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  C08L67/04 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/624 ,  A61L31/06 ,  C08L71/02 ,  A61L31/042 ,  C08L1/26 ,  A61L31/042 ,  C08L5/08 ,  A61L31/129 ,  C08L67/04 ,  A61L31/129 ,  C08L71/02 ,  A61L31/129 ,  C08L1/26 ,  A61L31/129 ,  C08L5/08 ,  A61L15/28 ,  C08L5/08 ,  A61L15/28 ,  C08L1/26 ,  A61L15/26 ,  C08L71/02

摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

公开(公告)号：US11911524B2

公开(公告)日：2024-02-27

申请号：US17469385

申请日：2021-09-08

申请人： Stryker European Operations Holdings LLC

发明人： Catharina Everdina Hissink ,  Theodorus Adrianus Cornelius Flipsen ,  Johan Zuidema ,  Linda Joan Gibcus

IPC分类号： A61L15/26 ,  C08G18/32 ,  A61L15/42 ,  A61L26/00 ,  C08L75/04 ,  A61L24/00 ,  A61L24/04 ,  C08G18/10 ,  C08G18/42 ,  C08G18/73 ,  A61L15/64 ,  C08G18/08 ,  C08G18/40

CPC分类号： A61L15/26 ,  A61L15/425 ,  A61L15/64 ,  A61L24/0036 ,  A61L24/046 ,  A61L26/0085 ,  C08G18/10 ,  C08G18/14 ,  C08G18/3206 ,  C08G18/4018 ,  C08G18/4277 ,  C08G18/73 ,  C08L75/04 ,  C08G2110/0083 ,  C08G2230/00 ,  A61L24/046 ,  C08L75/04 ,  C08G18/10 ,  C08G18/3206

摘要： The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

公开(公告)号：US11911521B2

公开(公告)日：2024-02-27

申请号：US17227940

申请日：2021-04-12

申请人： UNIVERSITY OF MANITOBA

发明人： Song Liu ,  Sarvesh Logsetty

IPC分类号： A61K9/70 ,  D01D5/00 ,  A61L15/24 ,  A61P17/02 ,  A61P31/04 ,  A61F13/00 ,  A61L15/26 ,  A61K47/32 ,  A61K47/34 ,  A61K9/00 ,  A61L15/46 ,  D01F1/10 ,  D01F8/14 ,  D01F8/10 ,  B82Y30/00

CPC分类号： A61K9/7007 ,  A61F13/00017 ,  A61K9/0092 ,  A61K9/703 ,  A61K47/32 ,  A61K47/34 ,  A61L15/24 ,  A61L15/26 ,  A61L15/46 ,  A61P17/02 ,  A61P31/04 ,  D01D5/0007 ,  D01F1/103 ,  D01F8/10 ,  D01F8/14 ,  A61F2013/00089 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/604 ,  A61L2400/12 ,  B82Y30/00 ,  A61L15/24 ,  C08L39/06 ,  A61L15/26 ,  C08L67/04

摘要： Bacteria-responsive core-shell nanofibers and a process for the preparation thereof are described. The nanofibers release of an antibacterial agent in response to the presence of bacteria. The core of the nanofiber comprises a biocompatible polymer together with an antibacterial agent such as a quaternary ammonium compound, for example benzyl dimethyl tetradecyl ammonium chloride (BTAC). Surrounding the core is shell comprised of a bacterially degradable polymer, which is susceptible to break-down by bacterial enzymes such as lipase, or to acidic pH conditions. The shell may comprise, for example, polycaprolactone (PCL) and poly(ethylene succinate) (PES). The nanofibers may be incorporated into wound dressings.

公开(公告)号：US20240042091A1

公开(公告)日：2024-02-08

申请号：US18205399

申请日：2023-06-02

申请人： STRYKER EUROPEAN OPERATIONS HOLDINGS LLC

发明人： Bhushan Chandrashekhar-Bhat ,  Robbert Arnold De Graaf

IPC分类号： A61L15/28 ,  A61L15/64 ,  A61L15/44 ,  A61L15/26 ,  A61L15/42

CPC分类号： A61L15/28 ,  A61L15/64 ,  A61L15/44 ,  A61L15/26 ,  A61L15/425 ,  A61L2300/232 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2300/236

摘要： The invention is directed a hemostatic foam, to a process for preparing a biodegradable hemostatic foam, and to the use of said foam. The hemostatic foam comprises a blend of a chitosan hemostatic agent and a polymer, which polymer provides the foam with a porosity of 85-99% and a foam density of 0.01-0.2 g/cm3.

公开(公告)号：US20240009351A1

公开(公告)日：2024-01-11

申请号：US18315355

申请日：2023-05-10

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

发明人： Daniel COHN ,  Ariel ELYASHIV ,  Abir KHALAILA ,  Aaron SLOUTSKI

IPC分类号： A61L27/36 ,  A61L31/04 ,  A61L31/00 ,  A61L31/16 ,  A61L31/02 ,  A61L17/10 ,  A61L17/00 ,  A61L17/14 ,  A61L17/08 ,  A61L15/40 ,  A61L15/44 ,  A61L15/18 ,  A61L15/26 ,  A61L27/54 ,  A61L27/04 ,  A61L27/18

CPC分类号： A61L27/36 ,  A61L31/04 ,  A61L31/005 ,  A61L31/16 ,  A61L31/022 ,  A61L17/10 ,  A61L17/005 ,  A61L17/145 ,  A61L17/08 ,  A61L15/40 ,  A61L15/44 ,  A61L15/18 ,  A61L15/26 ,  A61L27/54 ,  A61L27/04 ,  A61L27/18

摘要： The technology concerns a construct comprising at least one tissular region and at least one polymeric region for use as an implant.