公开(公告)号：US06339143B1

公开(公告)日：2002-01-15

申请号：US08487949

申请日：1995-06-07

申请人： Alexander Krichevsky ,  Steven Birken ,  John O'Connor ,  Robert E. Canfield

发明人： Alexander Krichevsky ,  Steven Birken ,  John O'Connor ,  Robert E. Canfield

IPC分类号： C07K16/26 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574 ,  G01N33/76

CPC分类号： C07K16/26 ,  G01N33/5091 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/76 ,  G01N2333/59 ,  G01N2333/705

摘要： This invention provides methods for detecting the presence of human malignant cells in a sample of tumor cells; determining whether a tumor present in a human subject is malignant; obtaining an enriched population of live human malignant cells; determining the amount of intact luteinizing hormone in a sample; determining the ovulatory stage of a subject; determining the amount of intact follicle stimulating hormone in a sample; determining the ovulatory stage of a subject; determining the amount of intact human chorionic gonadotropin in a sample; determining whether a subject is pregnant; determining the ovulatory stage of a subject; determining the amount of free &agr; subunit of human luteinizing hormone in a sample; determining whether a subject has a malignant tumor; determining the amount of nicked human chorionic gonadotropin in a sample; and determining the likelihood of a fetus's being afflicted with Down's syndrome.

摘要翻译： 本发明提供了用于检测肿瘤细胞样品中人恶性细胞存在的方法; 确定存在于人类受试者中的肿瘤是否是恶性的; 获得活的人类恶性细胞的富集群体; 确定样品中完整的黄体生成激素的量; 确定受试者的排卵期; 确定样品中完整的促卵泡激素的量; 确定受试者的排卵期; 确定样品中完整的人绒毛膜促性腺激素的量; 确定受试者是否怀孕; 确定受试者的排卵期; 测定样品中人黄体生成激素的游离α亚基的量; 确定受试者是否具有恶性肿瘤; 确定样品中切口的人绒毛膜促性腺激素的量; 并确定胎儿患有唐氏综合征的可能性。