公开(公告)号：US20240219409A1

公开(公告)日：2024-07-04

申请号：US18608269

申请日：2024-03-18

Applicant: Zomedica Biotechnologies LLC

Inventor： James Russell Webster

IPC: G01N33/78 ,  B01L3/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N33/543

CPC classification number: G01N33/78 ,  B01L3/502738 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N33/54386 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N2291/012 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2333/59

Abstract: A device that includes a first portion, the first portion including at least one fluid channel; a fluid actuator; and an introducer, a second portion, the second portion including at least one well, the well containing at least one material, wherein one of the first or second portion is moveable with respect to the other, wherein the introducer is configured to obtain at least a portion of the material from the at least one well and deliver it to the fluid channel, and wherein the fluid actuator is configured to move at least a portion of the material in the fluid channel.

公开(公告)号：US11935657B2

公开(公告)日：2024-03-19

申请号：US17408698

申请日：2021-08-23

Applicant: Reliant Immune Diagnostics, Inc.

Inventor： Jovan Hutton Pulitzer ,  Henry Joseph Legere, III

IPC: G06K9/00 ,  G01N33/53 ,  G01N33/543 ,  G06Q30/0251 ,  G06T7/00 ,  G16H10/65 ,  G16H50/30 ,  H04N23/60 ,  G06F3/0482

CPC classification number: G16H50/30 ,  G01N33/5302 ,  G01N33/54388 ,  G01N33/54389 ,  G01N33/54391 ,  G06Q30/0267 ,  G06Q30/0269 ,  G06T7/0014 ,  G16H10/65 ,  H04N23/64 ,  G01N2333/59 ,  G01N2333/9513 ,  G06F3/0482 ,  G06F2218/00

Abstract: A system and method are provided for collection and testing of a biologic sample. The system and method comprise collecting by a user of a testing device a biologic sample for use with the testing device, assigning correlative values as test results, and receiving the test results at a server disposed on a network. Some aspects further include presenting advertisements and other messages to users through a mobile application operating on a mobile device. These aspects take into account the results of the self-diagnostic test and present different advertisements to the user based on the results of the test.

公开(公告)号：US11802868B2

公开(公告)日：2023-10-31

申请号：US15804986

申请日：2017-11-06

Applicant: RELIANT IMMUNE DIAGNOSTICS, LLC

Inventor： Jovan Hutton Pulitzer ,  Henry Joseph Legere, III

IPC: G01N33/543 ,  G06T7/00 ,  G16H10/40 ,  G16H30/40 ,  G16H50/30 ,  G06T7/90 ,  G16H40/67 ,  G01N33/569 ,  G16H50/20 ,  G16H10/60

CPC classification number: G01N33/54388 ,  G01N33/54389 ,  G01N33/54391 ,  G01N33/56983 ,  G06T7/0012 ,  G06T7/90 ,  G16H10/40 ,  G16H30/40 ,  G16H40/67 ,  G16H50/30 ,  G01N2333/185 ,  G01N2333/59 ,  G06T2207/10024 ,  G06T2207/30004 ,  G16H10/60 ,  G16H50/20 ,  Y02A90/10

Abstract: A method for providing variable function medical tests, comprising providing by a mobile device application a plurality of selectable medical test functions, receiving information from the mobile device application regarding test results from a test performed using a testing device, wherein the testing device includes an alignment target disposed on the testing device and a plurality of immunoassay test strips receiving at the server an image of the testing device from the mobile device application, determining by the server RGB values for a plurality of pixels of the image, normalizing by the server the RGB values into a single value, comparing by the server the single value to a control value stored on the server, and providing by the server a risk indicator, wherein the risk indicator indicates a likelihood of a presence of a medical condition.

公开(公告)号：US20170052193A1

公开(公告)日：2017-02-23

申请号：US15118613

申请日：2015-02-13

Applicant: Concepta Diagnostics Limited

Inventor： Robert Porter ,  Zhi Zhang

IPC: G01N33/68 ,  G06F19/00 ,  G01N33/84 ,  G01N33/487 ,  G01N33/76 ,  G01N21/78

CPC classification number: G01N33/689 ,  G01N21/78 ,  G01N33/48792 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/76 ,  G01N33/84 ,  G01N2021/7759 ,  G01N2021/7793 ,  G01N2333/59 ,  G01N2800/368 ,  G16H40/63

Abstract: A pregnancy monitoring device and method improve detection in the first trimester of the occurrence of ectopic pregnancy and the occurrence of multiple foetuses. The device includes a sample absorbing member and an analyser to analyse a plurality of sequential a biological liquid samples and computing means to determine an ovulation date and deviations in the measured quantity of hCG from predetermined values which are indicators of ectopic pregnancy or multiple pregnancy. The device and method enables early detection of ectopic pregnancy or multiple pregnancy.

Abstract translation: 妊娠监测装置和方法改善妊娠前期发生异位妊娠和多发胎儿发生的检测。 该装置包括样本吸收构件和分析器，用于分析多个连续的生物液体样品和计算装置，以从作为异位怀孕或多次怀孕的指标的预定值确定测量的hCG量的排卵日期和偏差。 该装置和方法能够早期检测异位妊娠或多发怀孕。

公开(公告)号：US09575077B2

公开(公告)日：2017-02-21

申请号：US14927505

申请日：2015-10-30

Applicant: Abbott Point of Carie Inc.

Inventor： Dan Wang ,  Gordon Bruce Collier ,  Joseph P. Skinner ,  Qiaoqiao Ruan ,  Sergey Y. Tetin

IPC: G01N33/76 ,  G01N33/543 ,  C07K16/26 ,  G01N33/74 ,  G01N33/53 ,  B01L3/00

CPC classification number: G01N33/76 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/161 ,  B01L2300/163 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0688 ,  C07K16/26 ,  G01N33/5302 ,  G01N33/543 ,  G01N33/74 ,  G01N2333/59

Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).

Abstract translation: 本发明涉及使用在抗原捕获，检测抗体添加和底物引入步骤之间缺少一个或多个洗涤步骤的ELISA夹心测定来设计全血点护甲甲状腺刺激激素（TSH）免疫测定的抗体特征。 本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。

公开(公告)号：US09453850B2

公开(公告)日：2016-09-27

申请号：US14453918

申请日：2014-08-07

Applicant: Church & Dwight, Co., Inc.

Inventor： Andy Sturman ,  Benedict Zin ,  Albert Nazareth ,  Henry Bell

IPC: G01N21/03 ,  G01N33/68 ,  G01N21/84 ,  G01N21/17 ,  G01N33/493 ,  G01N33/62 ,  G01N33/76

CPC classification number: G01N33/48792 ,  G01N21/17 ,  G01N21/8483 ,  G01N33/48785 ,  G01N33/493 ,  G01N33/62 ,  G01N33/689 ,  G01N33/76 ,  G01N2201/062 ,  G01N2201/12 ,  G01N2333/59

Abstract: An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period.

Abstract translation: 用于检测流体样品中分析物的存在的改进的电子诊断装置包括具有显示器的壳体，安装在壳体中的测试条，安装在壳体中的处理器，以及安装在壳体中并可操作地耦合到 处理器。 该处理器被配置为当该设备暴露于环境光从而导致该设备被激活时从第一传感器接收信号。 该装置包括遮光板，其在测试条的宽度上施加压力，以防止沿着测试条的长度的流体通道。 处理器被配置为当在预定的早期测试时间段之后的任何时间测量值超过预定的早期读取阈值时呈现早期的正测试结果读数。

公开(公告)号：US20160223536A1

公开(公告)日：2016-08-04

申请号：US15025274

申请日：2014-10-09

Applicant: SONG DIAGNOSTIC RESEARCH LLC

Inventor： Martin D Johnson ,  Linda G Lee ,  Eric S Nordman ,  Mark F Oldham

IPC: G01N33/558 ,  G01N33/68 ,  G01N21/64 ,  G01N33/543 ,  G01N33/552

CPC classification number: G01N33/558 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/6893 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2333/161 ,  G01N2333/59 ,  G01N2800/26 ,  G01N2800/52 ,  Y02A50/53 ,  Y02A50/58

Abstract: Lateral flow test strips, systems, and methods are provided for measuring the presence and levels of analytes in samples in which the analyte may be complexed, for example within an analyte-antibody complex. Test strips are provided that can decomplex the analyte from the analyte-antibody complex during the lateral flow assay, resulting in high quality assays without the need for a decomplexation pre-treatment step. Various systems and methods for improving the performance of lateral flow assays are described, which include minimization of the Prozone effect, improved dynamic range, improving sensitivity by disrupting complexation of target antigens. The resulting lateral flow system has improved sensitivity and improved dynamic range, and may utilize fluorescence. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters for the excitation and emission light.

Abstract translation: 提供侧流测试条，系统和方法用于测量分析物可能在其中复合的样品中的分析物的存在和水平，例如在分析物 - 抗体复合物内。 提供了测试条，其可以在侧流测定期间使分析物 - 抗体复合物的分析物分解复合物，从而产生高质量的测定，而不需要解复合预处理步骤。 描述了用于改善侧流测定性能的各种系统和方法，其包括最小化Prozone效应，改善的动态范围，通过破坏靶抗原的复合来提高灵敏度。 所产生的横向流动系统具有改进的灵敏度和改善的动态范围，并且可以利用荧光。 照明系统使用LED，塑料镜片和塑料和彩色玻璃过滤器用于激发和发射光。

公开(公告)号：US20160213791A1

公开(公告)日：2016-07-28

申请号：US14913733

申请日：2014-08-22

Applicant: PREGTECH PTY LTD

Inventor： Nicolas Hans VOELKER

IPC: A61K49/00

CPC classification number: A61K49/0006 ,  A61B5/0082 ,  A61B5/4343 ,  A61B10/0012 ,  A61D17/002 ,  A61D17/006 ,  A61K49/0004 ,  G01N33/54373 ,  G01N33/689 ,  G01N33/76 ,  G01N2333/59

Abstract: The present disclosure relates to methods for detecting a biological parameter and to sensors for detecting a biological parameter. Certain embodiments of the present disclosure provide a method of detecting a biological parameter in a subject, the method comprising: implanting a sensor into the subject, wherein the sensor comprises an optical reflectance property between 400 and 1200 nm which is responsive to the biological parameter; detecting an optical reflectance property between 400 and 1200 nm through the skin of the subject from the implanted sensor, and using the optical reflectance property to detect the biological parameter.

Abstract translation: 本公开涉及用于检测生物参数的方法和用于检测生物参数的传感器。 本公开的某些实施例提供了一种检测受试者的生物学参数的方法，所述方法包括：将传感器植入到所述受试者中，其中所述传感器包括响应于所述生物学参数的400至1200nm的光学反射特性; 通过来自植入的传感器的被检体的皮肤检测400〜1200nm的光反射率，使用光反射率检测生物参数。

公开(公告)号：US20160178640A1

公开(公告)日：2016-06-23

申请号：US14910711

申请日：2014-04-29

Applicant: SARTORIUS STEDIM BIOTECH GMBH

Inventor： Dieter MELZNER ,  Denise VAN ROSSUM

IPC: G01N33/68 ,  B05D3/00 ,  B05D1/02 ,  B05D3/06 ,  G01N33/558 ,  G01N33/76

CPC classification number: G01N33/689 ,  B05D1/02 ,  B05D3/002 ,  B05D3/06 ,  G01N33/525 ,  G01N33/558 ,  G01N33/76 ,  G01N2333/59

Abstract: The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone (5) has a thickness (7) of 100 to 150 μm over the entire width of the membrane, the non-detection zone has a thickness (8) of at most 300 μm over the entire width of the membrane, and the lateral flow membrane arrangement (1) has a constant thickness (9), as well as to a lateral flow immunoassay device comprising said membrane arrangement (1).

Abstract translation: 本发明涉及一种横向流动膜装置（1），其包括微孔膜层（2）和液体不可渗透支撑层（3），用于通过微多孔膜层（2）横向流动液体，其中 微孔膜层（2）被支撑在液体不可渗透的支撑层（3）上并且具有至少一个检测区域（5）和至少一个非检测区域，其中结合剂固定在至少一个检测区域 如图5所示，液体不可渗透的支撑层（3）具有至少一个具有大厚度的区域和至少一个具有小厚度的区域，微孔膜层（2）被支撑在液体不可渗透的支撑层（3）上， 使得所述至少一个检测区域设置在具有大厚​​度的支撑层的所述至少一个区域上方，并且所述至少一个非检测区域设置在具有小厚度的支撑层的所述至少一个区域之上， 区域定向 在与所述液体的横向流动方向（a）正交的方向上，检测区域（5）在膜的整个宽度上具有100至150μm的厚度（7），非检测区域具有厚度 8）在膜的整个宽度上至多为300μm，并且横向流动膜装置（1）具有恒定的厚度（9），以及包括所述膜装置（1）的横向流动免疫测定装置。

公开(公告)号：US20160109465A1

公开(公告)日：2016-04-21

申请号：US14926375

申请日：2015-10-29

Applicant: Dan Wang ,  Gordon Bruce Collier ,  Joseph P. Skinner ,  Qiaoqiao Ruan ,  Sergey Y. Tetin

Inventor： Dan Wang ,  Gordon Bruce Collier ,  Joseph P. Skinner ,  Qiaoqiao Ruan ,  Sergey Y. Tetin

IPC: G01N33/76

CPC classification number: G01N33/76 ,  B01L3/50273 ,  B01L3/502738 ,  C07K16/26 ,  C07K2317/33 ,  G01N33/5302 ,  G01N33/543 ,  G01N33/74 ,  G01N2333/59

Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).

Abstract translation: 本发明涉及使用ELISA夹心测定法的低洗涤甲状腺刺激激素（TSH）免疫测定法，其在抗原捕获，检测抗体添加和底物引入步骤之间具有有限或不洗涤步骤。 本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。