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公开(公告)号：US06339143B1
公开(公告)日：2002-01-15
申请号：US08487949
申请日：1995-06-07
IPC分类号： C07K16/26 , G01N33/50 , G01N33/569 , G01N33/574 , G01N33/76
CPC分类号： C07K16/26 , G01N33/5091 , G01N33/56966 , G01N33/57492 , G01N33/76 , G01N2333/59 , G01N2333/705
摘要： This invention provides methods for detecting the presence of human malignant cells in a sample of tumor cells; determining whether a tumor present in a human subject is malignant; obtaining an enriched population of live human malignant cells; determining the amount of intact luteinizing hormone in a sample; determining the ovulatory stage of a subject; determining the amount of intact follicle stimulating hormone in a sample; determining the ovulatory stage of a subject; determining the amount of intact human chorionic gonadotropin in a sample; determining whether a subject is pregnant; determining the ovulatory stage of a subject; determining the amount of free &agr; subunit of human luteinizing hormone in a sample; determining whether a subject has a malignant tumor; determining the amount of nicked human chorionic gonadotropin in a sample; and determining the likelihood of a fetus's being afflicted with Down's syndrome.
摘要翻译： 本发明提供了用于检测肿瘤细胞样品中人恶性细胞存在的方法; 确定存在于人类受试者中的肿瘤是否是恶性的; 获得活的人类恶性细胞的富集群体; 确定样品中完整的黄体生成激素的量; 确定受试者的排卵期; 确定样品中完整的促卵泡激素的量; 确定受试者的排卵期; 确定样品中完整的人绒毛膜促性腺激素的量; 确定受试者是否怀孕; 确定受试者的排卵期; 测定样品中人黄体生成激素的游离α亚基的量; 确定受试者是否具有恶性肿瘤; 确定样品中切口的人绒毛膜促性腺激素的量; 并确定胎儿患有唐氏综合征的可能性。
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公开(公告)号：US5976876A
公开(公告)日：1999-11-02
申请号：US763669
申请日：1996-12-11
CPC分类号： C07K16/26
摘要： This invention provides an antibody which specifically binds to hLH.beta.cf without cross-reacting with hLH, hLH.beta. or hCG.beta.cf. In an embodiment, the monoclonal antibody is designated B505. In a further embodiment, the hybridoma cell line producing the monoclonal antibody B 505 is designated ATCC Accession No.12000. This invention provides different uses of the antibodies. Finally, this invention provides a method for determining the amount of hLH.beta.cf or hLH.beta.cf-related molecule in a sample.
摘要翻译： 本发明提供了一种特异性结合hLH beta cf而不与hLH，hLHβ或hCGβ比较的交叉反应的抗体。 在一个实施方案中，单克隆抗体命名为B505。 在另一个实施方案中，产生单克隆抗体B 505的杂交瘤细胞系称为ATCC登录号12000。 本发明提供了抗体的不同用途。 最后，本发明提供了一种测定样品中hLH beta cf或hLH beta cf相关分子量的方法。
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公开(公告)号：US07034124B2
公开(公告)日：2006-04-25
申请号：US09404076
申请日：1999-09-23
IPC分类号： C07K16/00
CPC分类号： C07K16/26
摘要： This invention provides an antibody which specifically binds to hLHβcf without cross-reacting with hLH, hLHβ or hCGβcf. In an embodiment, the monoclonal antibody is designated B505. In a further embodiment, the hybridoma cell line producing the monoclonal antibody B 505 is designated ATCC Accession No. 12000. This invention provides different uses of the antibodies. Finally, this invention provides a method for determining the amount of hLHβcf or hLHβcf-related molecule in a sample.
摘要翻译： 本发明提供了与hLHbetacf特异性结合而不与hLH，hLHbeta或hCGbetacf交叉反应的抗体。 在一个实施方案中，单克隆抗体命名为B505。 在另一个实施方案中，产生单克隆抗体B 505的杂交瘤细胞系被命名为ATCC登录号12000.本发明提供了抗体的不同用途。 最后，本发明提供了一种测定样品中hLHbetacf或hLHbetacf相关分子量的方法。
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公开(公告)号：US4851356A
公开(公告)日：1989-07-25
申请号：US72802
申请日：1987-07-14
IPC分类号： G01N33/574 , G01N33/577 , G01N33/76
CPC分类号： G01N33/76 , G01N33/57476 , G01N33/577 , Y10S436/804 , Y10S436/813 , Y10S436/814 , Y10S436/818 , Y10S436/823
摘要： An immunoassay for detecting and measuring hCG in a sample includes an antibody directed to the carboxy terminal portion of the .beta. subunit of hCG and a monoclonal antibody directed to a determinant on hCG at a locus sufficiently remote from the carboxy terminal portion of the .beta. subunit of hCG that both antibodies can simultaneously bind to hCG, wherein at least one of the antibodies is delectable when both are bound to hCG.In a presently preferred embodiment, an immunoassay for hCG or hCB.beta. in urine includes a purified, labeled or detectable serum-derived antibody directed to the carboxy-terminal portion of the .beta. subunit of hCG and a matrix-bound monoclonal antibody directed to a locus on the .beta. subunit sufficiently remote from the carboxy-terminal portion that both antibodies can simultaneously bind to hCG or hCG.beta..
摘要翻译： 用于检测和测量样品中的hCG的免疫测定包括针对hCG的β亚单位的羧基末端部分的抗体和针对hCG上的决定簇的单克隆抗体，其位于足够远离β-亚基的β亚基的羧基末端部分 两种抗体可以同时结合hCG的hCG，其中当二者结合hCG时，至少一种抗体是可选的。 在目前优选的实施方案中，尿中hCG或hCBβ的免疫测定包括针对hCG的β亚基的羧基末端部分的纯化的，标记的或可检测的血清衍生的抗体，以及针对基因座的基质结合的单克隆抗体 在足够远离羧基末端部分的β亚基上，两个抗体可以同时结合hCG或hCGβ。
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公开(公告)号：US08163508B2
公开(公告)日：2012-04-24
申请号：US13180845
申请日：2011-07-12
IPC分类号： G01N33/53
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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公开(公告)号：US06927034B2
公开(公告)日：2005-08-09
申请号：US09311428
申请日：1999-05-13
IPC分类号： G01N33/53 , C07K16/26 , C12N15/02 , G01N33/577 , G01N33/76 , G01N33/543 , G01N33/537
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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公开(公告)号：US08802381B2
公开(公告)日：2014-08-12
申请号：US13846172
申请日：2013-03-18
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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公开(公告)号：US07993858B2
公开(公告)日：2011-08-09
申请号：US12807513
申请日：2010-09-07
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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公开(公告)号：US20140087393A1
公开(公告)日：2014-03-27
申请号：US13846172
申请日：2013-03-18
IPC分类号： G01N33/76
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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公开(公告)号：US08420339B2
公开(公告)日：2013-04-16
申请号：US13446723
申请日：2012-04-13
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译： 本发明提供了通过确定样品中hCG的早期妊娠相关分子同种型的量来预测受试者的妊娠结局的方法。 本发明还提供了一种用于确定样品中人绒毛膜促性腺激素（hCG）的早期妊娠相关分子同种型的量的方法。 本发明还提供了用于确定样品中早期妊娠相关hCG的量的诊断试剂盒。 本发明另外提供了与人绒毛膜促性腺激素的早期怀孕相关分子同种型特异性结合的抗体。 最后，本发明提供了检测样品中滋养层细胞或非滋养层恶性肿瘤的方法。
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