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22 条记录 (耗时 0.037 秒)

    Dipeptide derivatives
    13.
    发明授权
    Dipeptide derivatives 失效
    二肽衍生物

    公开(公告)号：US06525047B2

    公开(公告)日：2003-02-25

    申请号：US09822738

    申请日：2001-03-30

    申请人： Philip Albert Carpino ,  David Andrew Griffith ,  Bruce Allen Lefker

    发明人： Philip Albert Carpino ,  David Andrew Griffith ,  Bruce Allen Lefker

    IPC分类号： A61K31517

    CPC分类号： C07D487/04 ,  A61K38/00 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/0207 ,  C07K5/021 ,  C07K5/06026

    摘要： This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis and/or frailty, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintenance of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis and/or frailty when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B- HT920. The invention is also directed to intermediates useful in the preparation of compounds of Formula I.

    摘要翻译： 本发明涉及式的化合物及其药学上可接受的盐，其中取代基如本说明书中所定义，其是生长激素分泌元素，并且其增加内源性生长激素的水平。 本发明的化合物可用于治疗和预防骨质疏松症和/或虚弱，充血性心力衰竭，与衰老相关的脆弱性，肥胖症; 加速骨折修复，减轻主要手术后的蛋白质分解代谢反应，减少慢性疾病引起的恶病质和蛋白质损失，加速伤口愈合，或加速烧伤患者或经历大手术的患者的恢复; 改善肌肉力量，移动性，维持皮肤厚度，代谢体内平衡或肾脏体内平衡。 当与以下物质组合使用时，本发明的化合物还可用于治疗骨质疏松症和/或虚弱：双膦酸盐化合物如阿仑膦酸盐; 雌激素，雌激素和可选的孕酮; 雌激素激动剂或拮抗剂; 或降钙素，以及对此有用的药物组合物。 此外，本发明涉及可用于增加人或其他动物中生长激素的内源性产生或释放的药物组合物，其包含有效量的本发明化合物和选自GHRP-6的生长激素促分泌素， Hexarelin，GHRP-1，生长激素释放因子（GRF），IGF-1，IGF-2或B-HT920。 本发明还涉及可用于制备式I化合物的中间体。

    Dipeptide derivatives
    14.
    发明授权
    Dipeptide derivatives 失效
    二肽衍生物

    公开(公告)号：US06433171B1

    公开(公告)日：2002-08-13

    申请号：US09823051

    申请日：2001-03-30

    申请人： Philip Albert Carpino ,  David Andrew Griffith ,  Bruce Allen Lefker

    发明人： Philip Albert Carpino ,  David Andrew Griffith ,  Bruce Allen Lefker

    IPC分类号： C07D48704

    CPC分类号： C07D487/04 ,  A61K38/00 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/0207 ,  C07K5/021 ,  C07K5/06026

    摘要： This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis and/or fraility, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintenance of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis and/or frailty when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B-HT920. The invention is also directed to intermediates useful in the preparation of compounds of Formula I.

    摘要翻译： 本发明涉及式的化合物及其药学上可接受的盐，其中取代基如本说明书中所定义，其是生长激素分泌元素，并且其增加内源性生长激素的水平。 本发明的化合物可用于治疗和预防骨质疏松症和/或虚弱，充血性心力衰竭，与衰老相关的脆弱性，肥胖症; 加速骨折修复，减轻主要手术后的蛋白质分解代谢反应，减少慢性疾病引起的恶病质和蛋白质损失，加速伤口愈合，或加速烧伤患者或经历大手术的患者的恢复; 改善肌肉力量，移动性，维持皮肤厚度，代谢体内平衡或肾脏体内平衡。 当与以下物质组合使用时，本发明的化合物还可用于治疗骨质疏松症和/或虚弱：双膦酸盐化合物如阿仑膦酸盐; 雌激素，雌激素和可选的孕酮; 雌激素激动剂或拮抗剂; 或降钙素，以及对此有用的药物组合物。 此外，本发明涉及可用于增加人或其他动物中生长激素的内源性产生或释放的药物组合物，其包含有效量的本发明化合物和选自GHRP-6的生长激素促分泌素， Hexarelin，GHRP-1，生长激素释放因子（GRF），IGF-1，IGF-2或B-HT920。 本发明还涉及可用于制备式I化合物的中间体。

    COMPOSITE COUNTERTOP MODULES WITH INTREGRAL BUILT-UP EDGE AND METHOD OF MAKING COUNTERTOPS
    16.
    发明申请
    COMPOSITE COUNTERTOP MODULES WITH INTREGRAL BUILT-UP EDGE AND METHOD OF MAKING COUNTERTOPS 审中-公开
    具有内置式边缘的复合计数器模块和制造计数器的方法

    公开(公告)号：US20120187808A1

    公开(公告)日：2012-07-26

    申请号：US13092961

    申请日：2011-04-24

    申请人： Andrew Griffith

    发明人： Andrew Griffith

    IPC分类号： A47B96/18 ,  B32B38/04

    CPC分类号： A47B77/022 ,  A47B96/18 ,  Y10T156/1062

    摘要： An improved countertop structure and method of manufacture thereof, said countertop structure having a laminate or composite horizontal upper surface and a laminate or composite vertical face with a front corner element adapted to form a contoured surface that smoothly fairs into both the upper surface and the face. The countertop is manufactured by first mounting a piece of solid surface sheet material to a plurality of elongated structural elements extending the length of said sheet and having thermal expansion compensation slots, the structural elements being strategically placed and adhered to the bottom surface of the solid surface sheet material to permit cutting to the desired width while providing the required structural support. The solid surface is bonded to the front vertical laminate surface and the front structural element to create a joined edge piece firmly attached to said sheet and said front structural element. The joined front edge piece and sheet is finished to the desired contour. The surface is then cut to the desired width and installed.

    摘要翻译： 一种改进的台面结构及其制造方法，所述台面结构具有层压体或复合水平上表面以及具有前角元件的层压板或复合垂直面，其适于形成平滑地展开到上表面和面中的轮廓表面 。 台面是通过首先将一片固体表面片材安装到延伸有所述片材的长度并具有热膨胀补偿槽的多个细长结构元件，其结构元件被策略地放置并粘附到固体表面的底表面 片材，以允许切割成所需的宽度，同时提供所需的结构支撑。 固体表面粘合到前垂直层压体表面和前结构元件以形成牢固地附接到所述片材和所述前结构元件的接合边缘片。 连接的前边缘片和片材被完成到所需的轮廓。 然后将表面切割成所需的宽度并安装。

    Transductin-1 and transductin-2 and applications to hereditary deafness
    18.
    发明申请
    Transductin-1 and transductin-2 and applications to hereditary deafness 失效
    Transductin-1和转导素-2以及遗传性耳聋的应用

    公开(公告)号：US20050196759A1

    公开(公告)日：2005-09-08

    申请号：US10792307

    申请日：2004-03-03

    申请人： Andrew Griffith ,  Kiyoto Kurima ,  Edward Wilcox ,  Thomas Friedman

    发明人： Andrew Griffith ,  Kiyoto Kurima ,  Edward Wilcox ,  Thomas Friedman

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K16/28 ,  C12N15/09 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C07K14/705 ,  C12Q2600/156

    摘要： The invention provides an isolated or purified nucleic acid molecule consisting essentially of the nucleotide sequence encoding transductin-2 (TDC2), related and derivative nucleic acid molecules, vectors comprising the isolated or purified nucleic acid sequences, cells comprising such vectors, polypeptides encoded by the nucleic acid molecules, monoclonal antibodies and cell lines producing the monoclonal antibodies. The invention also provides methods of treating, prognosticating and monitoring hearing loss.

    摘要翻译： 本发明提供了分离或纯化的核酸分子，其基本上由编码转氨酶-2（TDC2），相关和衍生的核酸分子的核苷酸序列组成，包含分离或纯化的核酸序列的载体，包含此类载体的细胞，由 核酸分子，单克隆抗体和产生单克隆抗体的细胞系。 本发明还提供治疗，预后和监测听力损失的方法。