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公开(公告)号:USD580496S1
公开(公告)日:2008-11-11
申请号:US29288687
申请日:2007-06-18
申请人: Kevin M. Reardon , Angela Smith
设计人: Kevin M. Reardon , Angela Smith
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公开(公告)号:USD565662S1
公开(公告)日:2008-04-01
申请号:US29288689
申请日:2007-06-18
申请人: Kevin M. Reardon , Angela Smith
设计人: Kevin M. Reardon , Angela Smith
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公开(公告)号:US20050221812A9
公开(公告)日:2005-10-06
申请号:US10133118
申请日:2002-04-26
申请人: Michael Gailey , Eric Portman , Chad Holmes , Michael Burgiss , Angela Smith
发明人: Michael Gailey , Eric Portman , Chad Holmes , Michael Burgiss , Angela Smith
IPC分类号: G06F17/30 , G06Q10/00 , G06Q30/00 , G10L13/00 , G10L15/00 , G10L15/08 , G10L15/10 , G10L15/18 , G10L15/26 , G10L15/28 , G10L19/00 , H04L29/08 , H04M3/42 , H04M3/493 , H04W4/02 , H04W76/02 , H04Q7/20
CPC分类号: G06F17/3043 , G06F17/30684 , G06F17/3087 , G06Q10/06 , G06Q30/02 , G10L15/1822 , G10L15/26 , G10L15/30 , G10L2015/228 , H04L67/18 , H04L67/306 , H04M3/42204 , H04M3/42348 , H04M3/4936 , H04M2201/40 , H04M2207/18 , H04M2242/15 , H04M2242/30 , H04W4/02 , H04W4/20 , H04W76/10
摘要: A method and system for routing call failures in a location-based services system. A remote terminal is connected to a location-based services system and is used to generate a voice-based tailored request for information. The voice-based tailored request for information is interpreted with a voice recognition application and a natural language processing application. If the voice recognition application or the natural language processing application fail to determine the meaning of the tailored request for information to a predetermined level of accuracy then the remote terminal is routed to a call center.
摘要翻译: 一种用于在基于位置的服务系统中路由呼叫失败的方法和系统。 远程终端连接到基于位置的服务系统,并用于生成基于语音的量身定制的信息请求。 用语音识别应用程序和自然语言处理应用程序解释基于语音的量身定制的信息请求。 如果语音识别应用程序或自然语言处理应用程序无法将定制的信息请求的含义确定为预定的准确度,则远程终端被路由到呼叫中心。
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公开(公告)号:US20050209239A1
公开(公告)日:2005-09-22
申请号:US11078614
申请日:2005-03-09
申请人: Barton Kamen , Peter Cole , Angela Smith , John Zebala
发明人: Barton Kamen , Peter Cole , Angela Smith , John Zebala
IPC分类号: A61K31/519
CPC分类号: A61K31/519
摘要: The present invention relates to pharmaceutical compositions containing the antifolate aminopterin, processes for making the compositions, and methods of using them to treat disorders in adult and pediatric patients. Pharmaceutical compositions substantially free of impurities are provided comprising a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof. Relative to the teachings of the prior art, the disclosed methods and compositions provide unexpected improvements that include a greater interpatient oral bioavailability in pediatric patients, a smaller interpatient coefficient of variation of oral bioavailability, a smaller mean intrapatient coefficient of variation of oral bioavailability, a greater therapeutic index, a smaller coefficient of variation of toxicity, efficacy in combination therapy, and efficacy of certain polyglutamated metabolites.
摘要翻译: 本发明涉及含有抗叶酸氨蝶呤的药物组合物,用于制备组合物的方法,以及使用它们治疗成人和儿科患者的疾病的方法。 提供了基本上不含杂质的药物组合物,其包含治疗有效量的氨基喋呤或其药学上可接受的盐。 相对于现有技术的教导,所公开的方法和组合物提供意想不到的改进,其包括在儿科患者中具有更大的患者口服生物利用度,口服生物利用度的较小的间质变异系数,口服生物利用度的较小的平均脑室内变异系数 更大的治疗指数,较小的毒性变异系数,联合治疗的疗效以及某些聚谷氨酸代谢物的功效。
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