公开(公告)号：US08696699B2

公开(公告)日：2014-04-15

申请号：US13280608

申请日：2011-10-25

Applicant: James E. Chomas ,  Leonard Pinchuk ,  John Martin ,  Aravind Arepally ,  Brett E. Naglreiter ,  Norman R. Weldon ,  Bryan M. Pinchuk

Inventor： James E. Chomas ,  Leonard Pinchuk ,  John Martin ,  Aravind Arepally ,  Brett E. Naglreiter ,  Norman R. Weldon ,  Bryan M. Pinchuk

IPC: A61M29/00

CPC classification number: A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0076 ,  A61F2230/008 ,  A61M25/005 ,  A61M25/0075 ,  A61M2025/0004 ,  A61M2025/0042 ,  A61M2025/0076 ,  A61M2025/0681

Abstract: An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve.

Abstract translation: 在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。 该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。 第一个细丝具有径向扩张阀的弹簧偏压。 向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。 导管的内腔与阀的中心连通。

公开(公告)号：US20120116351A1

公开(公告)日：2012-05-10

申请号：US13306105

申请日：2011-11-29

Applicant: James E. Chomas ,  Leonard Pinchuk ,  John Martin ,  Aravind Arepally ,  Brett E. Naglreiter ,  Norman R. Weldon ,  Bryan M. Pinchuk

Inventor： James E. Chomas ,  Leonard Pinchuk ,  John Martin ,  Aravind Arepally ,  Brett E. Naglreiter ,  Norman R. Weldon ,  Bryan M. Pinchuk

IPC: A61M25/14

CPC classification number: A61F2/013 ,  A61B17/00491 ,  A61B17/12186 ,  A61B2017/22082 ,  A61F2/01 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0076 ,  A61F2230/008 ,  A61M25/005 ,  A61M25/0075 ,  A61M2025/0004

Abstract: An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.

Abstract translation: 在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。 该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。 第一个细丝具有径向扩张阀的弹簧偏压。 向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。 导管的内腔与阀的中心连通。 该装置用于提供其中将治疗剂输注到器官中的治疗。

公开(公告)号：US20100047355A1

公开(公告)日：2010-02-25

申请号：US12226648

申请日：2007-04-24

Applicant: Jeff Bulte ,  Bradley Powers ,  Aravind Arepally ,  Dara Lee Kraitchman

Inventor： Jeff Bulte ,  Bradley Powers ,  Aravind Arepally ,  Dara Lee Kraitchman

IPC: A61K9/50 ,  A61K35/12 ,  G01R33/48

CPC classification number: A61K35/39 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/1818 ,  A61K49/1887 ,  A61K49/1896 ,  A61L31/022 ,  A61L31/042 ,  A61L31/047 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/45 ,  C08L5/04

Abstract: The present invention provides a microcapsule for implantation into a mammalian body, comprising: a) at least one cell and/or bioactive agent; and b) a biocompatible semi-permeable membrane encapsulating the at least one cell, wherein the biocompatible semi-permeable membrane comprises: at least one polycationic polymer region, at least one alginate polymer region, and a paramagnetic or superparamagnetic metal that does not participate in the crosslinking of the alginate polymer. The present invention further provides methods of making the microcapsules of this invention and use of the microcapsules of this invention in methods of delivering cells and/or therapeutic agents to a subject and in methods of embolization.

Abstract translation: 本发明提供一种用于植入哺乳动物体内的微胶囊，其包含：a）至少一种细胞和/或生物活性剂; 以及b）包封所述至少一个细胞的生物相容性半透膜，其中所述生物相容性半透膜包括：至少一个聚阳离子聚合物区域，至少一个藻酸盐聚合物区域和不参与所述至少一个藻酸盐聚合物区域的顺磁性或超顺磁性金属 藻酸盐聚合物的交联。 本发明进一步提供了制备本发明的微胶囊的方法以及本发明的微胶囊在对受试者和栓塞方法中递送细胞和/或治疗剂的方法中的用途。