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公开(公告)号：US20220332683A1
公开(公告)日：2022-10-20
申请号：US17724125
申请日：2022-04-19
发明人： Jun Wang
IPC分类号： C07D207/273 , C07D207/46 , A61K31/16 , A61P11/00 , A61P31/14 , C07D209/02 , A61K9/00
摘要： This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrrolidinone-acetamide (or similar) structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as inhibitors of the SARS-CoV-2 related viral 3CL protease (MPpro), which function as therapeutics for the treatment of viral infection characterized with PLPpro and/or Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLPpro and/or Mpro protease activity and/or expression.
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12.发明授权公开(公告)号：US11454759B2
公开(公告)日：2022-09-27
申请号：US16641297
申请日：2018-08-22
摘要： In accordance with a method of forming a waveguide in a polymer film disposed on a substrate, a plurality of regions on a polymer film are selectively exposed to a first dosage of radiation. The polymer film is formed from a material having a refractive index that decreases by exposure to the radiation and subsequent heating. At least one region of the polymer film that was not previously exposed to the radiation is selectively exposing to a second dosage of radiation. The second dosage of radiation is less than the first dosage of radiation. The polymer film is heated to complete curing of the polymer film.
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公开(公告)号：US20220291496A1
公开(公告)日：2022-09-15
申请号：US17638592
申请日：2020-08-28
发明人： Rongguang Liang
摘要： Methods, apparatus and systems that relate to a portable chromatic light microscope are described. One example chromatic light microscope includes a light source including light producing elements that produce non-monochromatic output light that can be modulated. The chromatic light microscope further includes an illumination subsection to receive light that is output from the light source. The illumination subsection includes one or more lenses to spatially disperse spectral contents of the light that is received by the illumination subsection and to deliver light having chromatic aberration to a target object. The chromatic light microscope also includes an imaging subsection that includes one or more lenses to receive scattered light from the target object and to deliver the same to a sensor, and a linear variable filter to selectively pass a portion of the light having a particular spectral range of wavelengths to the sensor.
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公开(公告)号：US20220283431A1
公开(公告)日：2022-09-08
申请号：US17634734
申请日：2020-08-12
发明人： Hong Hua , Hekun Huang
摘要： Methods and frameworks for designing and optimizing of high-performance light field displays, such as integral imaging head-mounted displays, are disclosed. The disclosed techniques enable user-defined metrics for characterizing the performance and optimization of such systems. One design method relates to an integral-imaging based three-dimensional (3D) display system that includes an arrayed optics, an arrayed display device to produce a plurality of elemental images, a first reference plane representing a virtual central depth plane (CDP), a second reference plane representing a viewing window for viewing a reconstructed 3D scene, and an optical subsection representing a model of a human eye. The method includes tracing rays starting at the arrayed display device, through the arrayed optics, and to the optical subsection for each element of the arrayed display device and arrayed optics, and adjusting one or more parameters to obtain at least a first metric value within a predetermined value.
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15.发明申请公开(公告)号：US20220276484A1
公开(公告)日：2022-09-01
申请号：US17633767
申请日：2020-08-10
发明人： Yuzuru Takashima , Brandon Hellman
摘要： A design and implementation of a new optical architecture: space, time, and angular division multiplexed image transfer by Digital Micromirror Device. The method, like various multiplexing methods employed in communication engineering, enables image transfer via an angular band-limited data channel such as an optical image guide by dynamically redistributing a signal into multiple domains such as space, time, angle, wavelength, and polarization.
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公开(公告)号：US20220274856A1
公开(公告)日：2022-09-01
申请号：US17631653
申请日：2020-07-31
摘要： A phyto-mediated wastewater treatment bioreactor (PWBR) for treating wastewater effluent and agricultural effluent is disclosed herein. The PWBR is used to clean and remove emerging contaminants from water. These emerging compounds include, but are not limited to, pharmaceutical compounds, steroids and hormones, and industrial and household chemicals. Plants and/or the microorganisms adhering to the plant roots and their growing medium have the ability to take up many of these contaminants and the PWBR maximizes their treatment capability in a given space and time.
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公开(公告)号：US11426366B2
公开(公告)日：2022-08-30
申请号：US15574346
申请日：2016-05-12
发明人： Scott Sherman , Torsten Falk , Miguel Estevez
IPC分类号： A61P25/26 , A61K31/135 , A61K31/166 , A61K31/198 , A61K31/454 , A61K31/4545 , A61K31/551 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/5415 , A61K31/4439 , A61P25/16
摘要： This invention provides methods utilizing ketamine for the treatment of motor disorders and/or side effects associated with certain medications used in the treatment of motor disorders. For example, in some embodiments, methods are provided for treating side effects associated with the administration of levodopa to a subject having Parkinson's disease, by administering a dose of ketamine or a pharmaceutically acceptable salt thereof. In particular, the invention provides methods for reducing dyskinesia associated with motor disorder (e.g., Parkinson's disease) treatments, and effective doses of ketamine or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220269086A1
公开(公告)日：2022-08-25
申请号：US17631713
申请日：2020-07-31
发明人： Brandon Hellman , Yuzuru Takashima
摘要： A light projection system includes an angle-dependent pattern projection device projecting light of multiple patterns into corresponding multiple directions, and a waveguide comprising an input and an output, configured to accept the light from the angle-dependent pattern projection device and emit the light through the output, whereby the light from each of the multiple patterns takes a unique path through the waveguide. The waveguide is built into a headset display device, and the output of the waveguide couples light emitted through the output to an eye.
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公开(公告)号：US20220257845A1
公开(公告)日：2022-08-18
申请号：US17047955
申请日：2019-04-25
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , Banner University Medical Group
发明人： Zain I. Khalpey , Zachary David Frankman , David A. Bull , Marvin J. Slepian , Richard G. Smith
摘要： Systems and methods for providing oxygenated blood to a patient, e.g., in a patient with inadequate or failing circulation, including a dual lumen cannula system for drawing blood from the heart and returning oxygenated blood therein. Methods may feature inserting the dual lumen cannula system through the left ventricle such that intake aperture are positioned entirely within the left ventricle and the tip of the cannula is positioned in the aorta of the patients heart. By fluidly connecting the cannula to a cardiac assistance device, deoxygenated blood may be drained from the left ventricle through the intake apertures and oxygenated blood may be pumped into the aorta thorough the tip.
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公开(公告)号：US20220243160A1
公开(公告)日：2022-08-04
申请号：US17622147
申请日：2020-06-26
摘要： A modular microfluidic device for simulating in vivo conditions of a biological system may include a first perfusion chamber having an inlet and an outlet, a second perfusion chamber having an inlet and an outlet, a well configured to hold one or more 3D structures of cultured biological cells. The well may be in fluid communication with the first and second perfusion chambers. A first porous membrane may be disposed between the first perfusion chamber and the well. A second porous membrane may be disposed between the second perfusion chamber and the well. The well may be configured to facilitate growth of cultured biological cells along all three dimensional axes, thereby providing or ensuring a more representative 3D structure of biological cells compared to conventional monolayer cultures.
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