公开(公告)号：US07342029B2

公开(公告)日：2008-03-11

申请号：US11187396

申请日：2005-07-22

Applicant: Olaf Ritzeler ,  Hans Ulrich Stilz ,  Bernhard Neises ,  Gerhard Jaehne ,  Joerg Habermann

Inventor： Olaf Ritzeler ,  Hans Ulrich Stilz ,  Bernhard Neises ,  Gerhard Jaehne ,  Joerg Habermann

IPC: A61K31/44 ,  A61K31/405 ,  C07D209/04

CPC classification number: C07D401/04 ,  C07D209/08 ,  C07D401/14

Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.

Abstract translation: 式I化合物适用于制备用于预防和治疗其中涉及NFκB活性升高的病症的药物。

公开(公告)号：US5498779A

公开(公告)日：1996-03-12

申请号：US447151

申请日：1995-05-22

Applicant: Bernhard Neises ,  Axel Ganzhorn ,  Celine Tarnus ,  Robert J. Broersma, Jr.

Inventor： Bernhard Neises ,  Axel Ganzhorn ,  Celine Tarnus ,  Robert J. Broersma, Jr.

IPC: A61K38/00 ,  C07K5/06 ,  C07K5/087 ,  A61K31/40

CPC classification number: C07K5/06191 ,  C07K5/0812 ,  A61K38/00 ,  Y10S514/822 ,  Y10S514/826

Abstract: This invention relates to novel polyfluorinated alkyl derivatives of certain tripeptides, to the methods for their preparation, the intermediates therefore, to their use in inhibiting thrombin and lung tryptase and in their end-use application as anti-coagulants useful in treating thrombophlebitis and coronary thrombosis and in the treatment of asthma.

Abstract translation: 本发明涉及某些三肽的新型多氟烷基衍生物，其制备方法，因此其中间体用于抑制凝血酶和肺类胰蛋白酶，并且在其最终用途中用作治疗血栓性静脉炎和冠状动脉血栓形成的抗凝血剂 和治疗哮喘。