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    Imidazolidine derivatives, the production thereof, their use and pharmaceutical preparations containing the same
    4.
    发明授权
    Imidazolidine derivatives, the production thereof, their use and pharmaceutical preparations containing the same 有权
    咪唑烷衍生物，其制备方法及其用途及药物制剂

    公开(公告)号：US06667334B1

    公开(公告)日：2003-12-23

    申请号：US09700178

    申请日：2001-03-12

    申请人： Bernhard Neises ,  Volkmar Wehner ,  Hans Ulrich Stilz

    发明人： Bernhard Neises ,  Volkmar Wehner ,  Hans Ulrich Stilz

    IPC分类号： A61K314166

    CPC分类号： C07K5/0202 ,  A61K38/00 ,  Y02A50/411

    摘要： The present invention relates to imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of diseases which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use, in particular as pharmaceutical active compounds, and pharmaceutical preparations which contain compounds of the formula I.

    摘要翻译： 本发明涉及式I的咪唑烷衍生物，其中B，E，W，Y，R，R 2，R 3，R 30，e和h具有权利要求中所示的含义。 式I的化合物是有价值的药物活性化合物，其适用于例如治疗和预防炎症性疾病，例如类风湿性关节炎或过敏性疾病。 式I的化合物是属于整联蛋白组的粘附受体VLA-4的白细胞和/或拮抗剂的粘附和迁移的抑制剂。 它们通常适用于治疗或预防由不良程度的白细胞粘附和/或白细胞迁移或与之相关的疾病或其中基于VLA- 4受体与其配体发挥作用。 本发明还涉及制备式I化合物，其用途，特别是作为药物活性化合物的方法和含有式I化合物的药物制剂。