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Patent Agency Ranking
公开(公告)号：US6005120A
公开(公告)日：1999-12-21
申请号：US778173
申请日：1997-01-02
Applicant: Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
Inventor： Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
IPC: C07C69/00 , C07D305/14 , C07D307/935 , C07D317/72 , C07D493/10 , C07D317/70
CPC classification number: C07D307/935 , C07D305/14 , C07D317/72 , C07D493/10 , C07F7/1856
Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
Abstract translation: 紫杉醇等三环和四环紫杉烷的合成。
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12.发明授权
公开(公告)号：US5760252A
公开(公告)日：1998-06-02
申请号：US769935
申请日：1996-12-19
Applicant: Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
Inventor： Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
IPC: C07D317/36 , C07C49/733 , C07C69/00 , C07C69/608 , C07C69/757 , C07D305/14 , C07D307/93 , C07D307/935 , C07D317/72 , C07D319/08 , C07D493/10 , C07F7/18
CPC classification number: C07D307/935 , C07D305/14 , C07D307/93 , C07D317/72 , C07D493/10
Abstract: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
Abstract translation: 紫杉醇和其他三环和四环紫杉烷的合成方法。
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13.发明授权
公开(公告)号：US5618952A
公开(公告)日：1997-04-08
申请号：US383956
申请日：1995-02-06
Applicant: Robert A. Holton , Carmen Somoza , Hyeong B. Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
Inventor： Robert A. Holton , Carmen Somoza , Hyeong B. Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
IPC: C07D317/36 , C07C49/733 , C07C69/00 , C07C69/608 , C07C69/757 , C07D305/14 , C07D307/93 , C07D307/935 , C07D317/72 , C07D319/08 , C07D493/10 , C07F7/18 , C07D307/77
CPC classification number: C07D307/935 , C07D305/14 , C07D307/93 , C07D317/72 , C07D493/10
Abstract: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
Abstract translation: 紫杉醇和其他三环和四环紫杉烷的合成方法。
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公开(公告)号：US08450348B2
公开(公告)日：2013-05-28
申请号：US11708793
申请日：2007-02-21
Applicant: Krishna K. Murthi , Roland Köstler , Chase Smith , Tilman Brandstetter , Arthur F. Kluge
Inventor： Krishna K. Murthi , Roland Köstler , Chase Smith , Tilman Brandstetter , Arthur F. Kluge
IPC: A61K31/44 , C07D213/74
CPC classification number: C07D213/74 , C07D401/12 , C12N5/0693 , C12N2501/06
Abstract: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
Abstract translation: 本发明提供方酸的衍生物，特别是3,4-二氨基 - 环丁-3-烯-1,2-二酮及其互变异构体及其异构体的衍生物作为单一立体异构体或立体异构体的混合物，或作为药学上可接受的盐 其可接受的盐。 这些化合物显示抗增殖活性，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。
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公开(公告)号：US06433189B1
公开(公告)日：2002-08-13
申请号：US09907330
申请日：2001-07-17
Applicant: Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
Inventor： Robert A. Holton , Carmen Somoza , Hyeong Baik Kim , Mitsuru Shindo , Ronald J. Biediger , P. Douglas Boatman , Chase Smith , Feng Liang , Krishna Murthi
IPC: C07D31770
Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
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