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15 条记录 (耗时 0.052 秒)

    1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel
    9.
    发明申请
    1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel 审中-公开
    1,2-二氢 - 螺[3H-吲哚-3,4'-哌啶]化合物，作为Mas受体小分子的调节剂

    公开(公告)号：US20080200491A1

    公开(公告)日：2008-08-21

    申请号：US11917731

    申请日：2006-06-21

    申请人： Thuy-Anh Tran ,  Sangdon Han ,  P. Douglas Boatman

    发明人： Thuy-Anh Tran ,  Sangdon Han ,  P. Douglas Boatman

    IPC分类号： A61K31/438 ,  C07D471/10 ,  A61P9/10 ,  A61P25/02 ,  A61P25/16

    CPC分类号： C07D471/10

    摘要： The present invention relates to certain 1,2-dihydro-spiro[3H-indole-3,4′-piperidine]compounds of Formula (Ia): and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein G, R1, R2, R3, R4, R5, and Ar are as disclosed herein (“Compound(s) of the Invention”), which are useful, for example, as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.

    摘要翻译： 本发明涉及式（Ia）的某些1,2-二氢螺[3H-吲哚-3,4'-哌啶]化合物及其药学上可接受的盐，溶剂化物和水合物，其中G，R1，R2，R3 ，R4，R5和Ar如本文所公开的（“本发明的化合物”），其可用作例如心保护和/或神经保护剂。 本发明还提供了包含本发明化合物和治疗，预防和/或控制血管，心血管或神经疾病或病症的方法的药物组合物，其包括向有需要的患者施用本发明的化合物。

    FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
    10.
    发明申请
    FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF 审中-公开
    熔化的吡唑衍生物及其代谢相关疾病的治疗方法

    公开(公告)号：US20090258892A1

    公开(公告)日：2009-10-15

    申请号：US12433704

    申请日：2009-04-30

    申请人： P. Douglas Boatman ,  Thomas O. Schrader ,  Graeme Semple ,  Philip J. Skinner ,  Jae-Kyu Jung

    发明人： P. Douglas Boatman ,  Thomas O. Schrader ,  Graeme Semple ,  Philip J. Skinner ,  Jae-Kyu Jung

    IPC分类号： A61K31/437 ,  C07D231/54 ,  C07D403/04 ,  A61K31/416 ,  A61K31/41 ,  A61K31/40

    CPC分类号： C07D403/04 ,  C07D209/80 ,  C07D209/88 ,  C07D231/54 ,  C07D265/36 ,  C07D471/04 ,  C07D471/14

    摘要： The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

    摘要翻译： 本发明涉及式（Ia）的某些稠合吡唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病的方法 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂，DP受体拮抗剂等。