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公开(公告)号：US20050129734A1
公开(公告)日：2005-06-16
申请号：US11037011
申请日：2005-01-19
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K9/20 , A61K9/22 , A61K9/58 , A61K47/36 , C08B37/02 , C08G18/64 , C08G18/81 , C08L5/02 , C08L67/07 , A61F2/06 , A61F2/00
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.
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12.发明授权Hydrogel entrapping therapeutic agent and stent with coating comprising this 有权水凝胶包埋治疗剂和含有该涂层的涂层的支架公开(公告)号：US07138132B2
公开(公告)日：2006-11-21
申请号：US11037011
申请日：2005-01-19
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.
Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。
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Patent Agency Ranking
13.发明授权Hydrogel entrapping therapeutic agent and stent with coating comprising this 失效水凝胶包埋治疗剂和含有该涂层的涂层的支架公开(公告)号：US06905700B2
公开(公告)日：2005-06-14
申请号：US10762256
申请日：2004-01-23
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K9/20 , A61K9/22 , A61K9/58 , A61K47/36 , C08B37/02 , C08G18/64 , C08G18/81 , C08L5/02 , C08L67/07 , C08G63/08
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.
Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。
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公开(公告)号：US06583219B2
公开(公告)日：2003-06-24
申请号：US10096435
申请日：2002-03-13
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K958
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
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公开(公告)号：US07504477B2
公开(公告)日：2009-03-17
申请号：US11386876
申请日：2006-03-22
Applicant: Chee-Youb Won
Inventor： Chee-Youb Won
CPC classification number: C08G65/337 , A61K47/60 , C08G65/329 , C08G65/3322 , C08L2203/02
Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.
Abstract translation: 一类新的活性聚亚烷基二醇酸及其活性酯试剂，用于与生物药物如多肽，糖，蛋白质和治疗活性的小分子结合，以产生这些药物的生物活性缀合物和制备这些缀合物的方法。
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公开(公告)号：US07273909B2
公开(公告)日：2007-09-25
申请号：US10623978
申请日：2003-07-21
Applicant: Chee-Youb Won
Inventor： Chee-Youb Won
IPC: C08G65/324 , C08G65/327 , C08G35/331
CPC classification number: C08G65/324 , C08G65/329 , C08G65/331
Abstract: Polyethylene glycol aldehyde compounds are provided. Methods of making and using such compounds, as well as chemical intermediates are also provided.
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17.发明授权Hydrogel entrapping therapeutic agent and stent with coating comprising this 失效水凝胶包埋治疗剂和含有该涂层的涂层的支架公开(公告)号：US06716445B2
公开(公告)日：2004-04-06
申请号：US10143572
申请日：2002-05-13
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K958
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.
Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。
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