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公开(公告)号：US20070167606A1
公开(公告)日：2007-07-19
申请号：US11724009
申请日：2007-03-14
Applicant: Chee-Youb Won
Inventor： Chee-Youb Won
IPC: C08G65/34 , C07C271/20 , C07C275/14
CPC classification number: C08G65/324 , C08G65/329 , C08G65/331
Abstract: Polyethylene glycol aldehyde compounds are provided. Methods of making and using such compounds, as well as chemical intermediates are also provided.
Abstract translation: 提供聚乙二醇醛化合物。 还提供了制备和使用这些化合物的方法以及化学中间体。
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公开(公告)号：US07084261B2
公开(公告)日：2006-08-01
申请号：US10625103
申请日：2003-07-22
Applicant: Pascal S. Bailon , Chee-Youb Won
Inventor： Pascal S. Bailon , Chee-Youb Won
CPC classification number: C07K14/005 , A61K38/00 , A61K47/60 , C12N2740/15022 , C12N2740/16122
Abstract: Pegylated T1249 polypeptide compounds are provided. Also provided are pharmaceutical compositions containing pegylated T1249 polypeptide compounds, and methods of making. Further provided are methods of inhibiting HIV infection using such compounds and compositions.
Abstract translation: 提供了聚乙二醇化的T1249多肽化合物。 还提供了含有聚乙二醇化T1249多肽化合物的药物组合物和制备方法。 还提供了使用这些化合物和组合物来抑制HIV感染的方法。
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公开(公告)号：US20060167218A1
公开(公告)日：2006-07-27
申请号：US11386876
申请日：2006-03-22
Applicant: Chee-Youb Won
Inventor： Chee-Youb Won
CPC classification number: C08G65/337 , A61K47/60 , C08G65/329 , C08G65/3322 , C08L2203/02
Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.
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公开(公告)号：US07049415B2
公开(公告)日：2006-05-23
申请号：US10623873
申请日：2003-07-21
Applicant: Pascal Sebastian Bailon , Chee-Youb Won
Inventor： Pascal Sebastian Bailon , Chee-Youb Won
CPC classification number: C07K14/005 , A61K38/00 , C12N2740/16122
Abstract: Pegylated T20 polypeptide compounds are provided. Also provided are pharmaceutical compositions containing pegylated T20 polypeptide compounds, and methods of making and using such compounds and compositions.
Abstract translation: 提供了聚乙二醇化的T20多肽化合物。 还提供含有聚乙二醇化的T20多肽化合物的药物组合物，以及制备和使用这些化合物和组合物的方法。
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公开(公告)号：US06916857B2
公开(公告)日：2005-07-12
申请号：US10733291
申请日：2003-12-12
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K9/20 , A61K9/22 , A61K9/58 , A61K31/405 , A61K38/00 , A61K38/28 , A61K47/32 , A61K47/36 , A61P3/10 , A61P29/00 , C08B37/02 , C08F299/00 , C08G18/64 , C08G18/81 , C08L5/02 , C08L67/07 , C08G63/08
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g. dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
Abstract translation: 包含具有不饱和基团末端的疏水性大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的羟基的多糖（例如葡聚糖），可通过自由基聚合反应形成含有 含有疏水和亲水组分的三维交联聚合物网络。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。
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Patent Agency Ranking
公开(公告)号：US06388047B1
公开(公告)日：2002-05-14
申请号：US09531451
申请日：2000-03-20
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: A61K958
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Preferably, the hydrophobic polymer is prepared by reacting the hydroxyls of a diol obtained by converting hydroxy of terminal carboxylic acid group of poly(lactic acid) to aminoethanol group, with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of the molecule. Preferably, the hydrophilic polymer is dextran wherein one or more hydroxyls in a glucose unit of the dextran is (are) reacted with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of a molecule. Agent can be entrapped in the polymer network, e.g., drugs, water-soluble macromolecules or synthetic or natural polymers, for controlled release therefrom.
Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 优选地，疏水性聚合物通过将通过将聚（乳酸）的末端羧酸基团的羟基与氨基乙醇基团的羟基与不饱和基团引入化合物（其是丙烯酰氯或具有不饱和基团的异氰酸酯） 分子的一端。 优选地，亲水性聚合物是葡聚糖，其中葡聚糖的葡萄糖单元中的一个或多个羟基与不饱和基团引入化合物反应，该化合物是分子的一端具有不饱和基团的丙烯酰氯或异氰酸酯。 药剂可以被包埋在聚合物网络中，例如药物，水溶性大分子或合成或天然聚合物，用于从其中控释。
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公开(公告)号：US06709668B2
公开(公告)日：2004-03-23
申请号：US10369676
申请日：2003-02-21
Applicant: Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
Inventor： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC: C09D400
CPC classification number: C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的含羟基的多糖（例如，葡聚糖），可通过自由基聚合反应形成含有 含有疏水和亲水组分的三维交联聚合物网络。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。
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公开(公告)号：US08524215B2
公开(公告)日：2013-09-03
申请号：US13193958
申请日：2011-07-29
Applicant: Chee-Youb Won , Helen Cui
Inventor： Chee-Youb Won , Helen Cui
IPC: A61K31/74
CPC classification number: A61K9/0024 , A61K9/06 , A61K47/10 , A61K47/34 , C08L71/02 , C08L2201/56
Abstract: An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.
Abstract translation: 由具有约3至约8个臂的多臂-PEG-乙烯基砜制备的可吸收PEG基水凝胶和具有约3至约8个臂的多臂-PEG-R-巯基; 其中R被定义为酯键，例如羧酸酯，乳酸酯和异丁酸酯。 此外，已经公开了由可吸收的基于PEG的水凝胶和蛋白质制备的持续释放组合物，其提供蛋白质和肽的持续释放。
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公开(公告)号：US20120027775A1
公开(公告)日：2012-02-02
申请号：US13193958
申请日：2011-07-29
Applicant: Chee-Youb Won , Helen Cui
Inventor： Chee-Youb Won , Helen Cui
IPC: A61K39/395 , A61K47/40 , A61P37/00 , A61K47/20
CPC classification number: A61K9/0024 , A61K9/06 , A61K47/10 , A61K47/34 , C08L71/02 , C08L2201/56
Abstract: An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.
Abstract translation: 由具有约3至约8个臂的多臂-PEG-乙烯基砜制备的可吸收PEG基水凝胶和具有约3至约8个臂的多臂-PEG-R-巯基; 其中R被定义为酯键，例如羧酸酯，乳酸酯和异丁酸酯。 此外，已经公开了由可吸收的基于PEG的水凝胶和蛋白质制备的持续释放组合物，其提供蛋白质和肽的持续释放。
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公开(公告)号：US07193031B2
公开(公告)日：2007-03-20
申请号：US10625033
申请日：2003-07-22
Applicant: Pascal Sebastian Bailon , Chee-Youb Won
Inventor： Pascal Sebastian Bailon , Chee-Youb Won
IPC: C08G65/34
CPC classification number: C08G65/337 , A61K47/60 , C08G65/329 , C08G65/3322 , C08L2203/02
Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.
Abstract translation: 一类新的活性聚亚烷基二醇酸及其活性酯试剂，用于与生物药物如多肽，糖，蛋白质和治疗活性的小分子结合，以产生这些药物的生物活性缀合物和制备这些缀合物的方法。
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