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    Hydrogel entrapping therapeutic agent and stent with coating comprising this
    4.
    发明授权
    Hydrogel entrapping therapeutic agent and stent with coating comprising this 有权
    水凝胶包埋治疗剂和含有该涂层的涂层的支架

    公开(公告)号：US07138132B2

    公开(公告)日：2006-11-21

    申请号：US11037011

    申请日：2005-01-19

    申请人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    发明人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC分类号： C09D4/00 ,  A61L25/00 ,  A61L27/00 ,  A61L29/00

    CPC分类号： C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

    摘要翻译： 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。

    Contact lens
    5.
    发明申请
    Contact lens 有权

    公开(公告)号：US20060012751A1

    公开(公告)日：2006-01-19

    申请号：US10470651

    申请日：2003-07-09

    申请人： Howard Rosenzweig ,  Michael Quinn ,  Robert Tucker ,  Greg Carlson ,  Gerardo Ocampo

    发明人： Howard Rosenzweig ,  Michael Quinn ,  Robert Tucker ,  Greg Carlson ,  Gerardo Ocampo

    IPC分类号： G02C7/04

    CPC分类号： G02B1/043 ,  C08F220/56 ,  C08F230/08 ,  Y10S525/937 ,  C08L43/04 ,  C08L83/04

    摘要： This invention is directed to ophthalmic materials and ophthalmic lenses that are a co-polymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group-containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer, as well as optional monomers or monomer mixtures that can include a cationic monomer, a non-aromatic hydrophobic monomer and a poly(dimethylsiloxy)silyl group-containing monomer. A contact lens prepared from such a co-polymer exhibits enhanced water content, while maintaining exceptional oxygen permeability, thereby providing a lens that can be worn comfortably for prolonged periods of time. A process for the preparation of such lenses is also disclosed.

    Non-oxidizing polymeric medical implant
    7.
    发明申请
    Non-oxidizing polymeric medical implant 审中-公开
    非氧化聚合物医疗植入物

    公开(公告)号：US20050059750A1

    公开(公告)日：2005-03-17

    申请号：US10935510

    申请日：2004-09-07

    申请人： Deh-Chuan Sun ,  Casper Stark

    发明人： Deh-Chuan Sun ,  Casper Stark

    IPC分类号： A61L27/00 ,  A61L2/08 ,  A61L15/60 ,  A61L27/16 ,  A61L29/04 ,  A61L31/00 ,  A61L31/04 ,  A61L33/00 ,  B29C35/08 ,  B29C43/00 ,  B29C43/16 ,  C08F2/46 ,  C08G2/00

    CPC分类号： A61L2/081 ,  A61L2/08 ,  A61L2/082 ,  A61L2/087 ,  A61L15/60 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  B29C35/0805 ,  B29C43/00 ,  B29C43/16 ,  B29C2035/085 ,  B29K2023/0683 ,  B29K2105/253 ,  B29K2995/0087 ,  B29K2995/0089 ,  B29L2031/7532 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S623/901 ,  C08L23/06 ,  C08L23/04

    摘要： A medical implant made of polymeric material having an increased oxidation resistance is formed by a method including the steps of placing a resin powder in a sealed container. A substantial portion of the oxygen is removed from the sealed contained by either a vacuum, an oxygen absorbent or by flushing with inert gas. The container is then repressurized with a gas such as nitrogen, argon, helium or neon so that long term storage may be possible. On use, the resin in transferred to a forming device which both melts and forms the resin in an oxygen reduced atmosphere to produce a polymeric raw material such as a rod or bar stock. The medical implant is then formed from this raw material annealed and sealed in an airtight package in an oxygen reduced atmosphere. The implant is then radiation sterilized and thereafter annealed in the package for a predetermined time and temperature sufficient to form cross-links between any free radicals in neighboring polymeric chains.

    摘要翻译： 通过包括将树脂粉末放置在密封容器中的步骤的方法形成由聚合物材料制成的具有增加的抗氧化性的医疗植入物。 通过真空，氧吸收剂或通过用惰性气体冲洗，将氧气的相当一部分从密封物中除去。 然后将容器用诸如氮气，氩气，氦气或氖气的气体再加压，以便长期储存是可能的。 使用时，转移到成形装置中的树脂，其在氧还原气氛中熔融并形成树脂，以生产聚合物原料，例如棒材或棒料。 然后将医用植入物从该原料中形成，并在氧气还原气氛中以气密封装形式退火并密封。 然后将植入物辐射灭菌，然后在包装中退火预定的时间和温度，足以在相邻聚合物链中的任何自由基之间形成交联。

    Shape memory polyurethane or polyurethane-urea polymers
    8.
    发明授权
    Shape memory polyurethane or polyurethane-urea polymers 失效
    形状记忆聚氨酯或聚氨酯 - 脲聚合物

    公开(公告)号：US06858680B2

    公开(公告)日：2005-02-22

    申请号：US10054742

    申请日：2002-01-22

    申请人： Pathiraja A. Gunatillake ,  Simon J. McCarthy ,  Gordon F. Meijs ,  Raju Adhikari

    发明人： Pathiraja A. Gunatillake ,  Simon J. McCarthy ,  Gordon F. Meijs ,  Raju Adhikari

    IPC分类号： A61L27/00 ,  A61L27/18 ,  A61L27/26 ,  A61L27/50 ,  A61L29/04 ,  A61L29/06 ,  A61L29/14 ,  A61L31/00 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  C08G18/38 ,  C08G18/48 ,  C08G18/61 ,  C08G18/66 ,  C08J5/00 ,  C08L75/00 ,  C08L75/04 ,  C08L101/00 ,  C08G77/38

    CPC分类号： C08G18/6674 ,  A61L27/18 ,  A61L27/26 ,  A61L27/50 ,  A61L29/049 ,  A61L29/06 ,  A61L29/14 ,  A61L31/041 ,  A61L31/06 ,  A61L31/14 ,  A61L2400/16 ,  C08G18/3893 ,  C08G18/4858 ,  C08G18/61 ,  C08G2280/00 ,  C08L75/04 ,  Y10S525/937 ,  C08L75/02 ,  C08L83/04

    摘要： A shape memory polyurethane or polyurethane-urea polymer including a reaction product of: (A) (a) silicon-based macrodiol, silicon-based macrodiamine and/or polyether of the formula (I): A—[(CH2)m—O]n—(CH2)m—A′, wherein A and A are endcapping groups; m is an integer of 6 or more; and n is an integer of 1 or greater; (b) a diisocyanate; and (c) a chain extender; or (B) (b) a diisocyanate: and (c) a chain extender, said polymer having a glass transition temperature which enables the polymer to be formed into a first shape at a temperature higher than the glass transition temperature and maintained in said first shape when the polymer is cooled to a temperature lower than the glass transition temperature, said polymer then being capable of resuming its original shape on heating to a temperature higher than the glass transition temperature. The present invention also relates to a shape memory composition which includes a blend of two or more of the shape memory polyurethane or polyurethane-urea polymers defined above or at least one shape memory polyurethane or polyurethane-urea polymer defined above in combination with another material. The present invention further relates to processes for preparing materials having improved mechanical properties, clarity, processability, biostability and/or degradation resistance and devices or articles containing the shape memory polyurethane or polyurethane-urea polymer and/or composition defined above.

    摘要翻译： 一种形状记忆聚氨酯或聚氨酯 - 脲聚合物，其包括以下反应产物：（A）（a）硅基大分子二醇，硅基大二胺和/或式（I）的聚醚：A - [（CH 2）m O] n - （CH 2）m -A'，其中A和A'是封端基团; m为6以上的整数， n为1以上的整数， （b）二异氰酸酯; 和（c）扩链剂; 或（B）（b）二异氰酸酯和（c）扩链剂，所述聚合物具有玻璃化转变温度，使聚合物能够在高于玻璃化转变温度的温度下形成第一形状，并保持在所述第一 当聚合物冷却至低于玻璃化转变温度的温度时，所述聚合物在加热至高于玻璃化转变温度的温度时能够恢复其原始形状。 本发明还涉及一种形状记忆组合物，其包括两种或更多种上述定义的形状记忆聚氨酯或聚氨酯 - 脲聚合物或至少一种形状记忆聚氨酯或聚氨酯 - 脲聚合物与另一种材料组合的共混物。 本发明还涉及制备具有改进的机械性能，透明度，可加工性，生物稳定性和/或耐降解性的材料的方法以及含有上述定形形状记忆聚氨酯或聚氨酯 - 脲聚合物和/或组合物的装置或制品。

    Reinforced implantable medical devices
    9.
    发明申请
    Reinforced implantable medical devices 有权
    强化可植入医疗器械

    公开(公告)号：US20040254639A1

    公开(公告)日：2004-12-16

    申请号：US10401469

    申请日：2003-03-28

    发明人： Zhigang Li ,  Mark B. Roller ,  Murty N. Vyakarnam ,  Jenny J. Yuan ,  Joseph H. Contiliano ,  Yufu Li

    IPC分类号： A61F002/06

    CPC分类号： A61L31/127 ,  A61L31/125 ,  A61L31/148 ,  Y10S525/937

    摘要： The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.

    摘要翻译： 本发明涉及适用于至少部分由这样的组合物制备的可植入医疗装置和医疗装置的增强的，生物相容的，可生物降解的组合物，其中组合物包括生物相容的可生物降解的聚合物; 生物相容的，可生物降解的蜡; 和大于约30重量％的无机填料。