Abstract:
The present invention relates to a class of substituted 1,2,4-triazoles of formula (1) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).
Abstract:
The present invention relates to a method of manipulating a software application and processing data stored in a data source. The method includes receiving a natural language input and analyze the natural language input to identify semantic information contained therein. Portions of the natural language input are associated with command objects and entity objects of a schema based on the semantic information and the natural language input. The method also includes rendering data from the data source in a table of columns and rows based on the schema and the associated portions of the natural language input.
Abstract:
A system and method for automatically completing a formula of a spreadsheet application, calculator application, accounting application, business application or banking application. One aspect of the present invention is a computer-implemented method for automatically completing formulaic cell data. The computer-implemented method includes a step for substantiating an autocomplete process in response to a user input of formulaic cell data and aggregating autocomplete options based on the user input. Another aspect of the present invention includes displaying a dynamic list of autocomplete options when the user input is a trigger.
Abstract:
The present invention is directed towards a method for making a healthy snack food having an appearance and taste similar to conventional fried snack products without the use of an oil-frying process. The method of the present invention includes the steps of providing food slices from a starch-based food or dough. The food slices can be blanched and a controlled amount of oil can be added to enhance final organoleptical properties. The food slices are then rapidly dehydrated to a much lower moisture content in a primary drying step that simulates conventional frying dehydration rates. A food snack, such as a corn or potato-based snack, produced by this method is a low-fat, ready-to-eat snack having the conventional texture and taste associated with fried snack products.
Abstract:
The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyil, buprenorphine, and sufentanil, or its pharmaceutically acceptable salts thereof, wherein the ω-conopeptide retains its potency and is physically and chemically compatible with the analgesic compound. A preferred route of administration is intrathecal administration, particularly continuous intrathecal infusion. The present invention is also directed to a pharmaceutical formulation comprising an omega conopeptide, preferably ziconotide, an antioxidant, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine, and sufentanil.
Abstract:
An inspection system for removably mounting to a platform movable in relation to a generally upright mast for inspection of the mast has a mounting support assembly removably fixable to the platform. The mounting support assembly for scanning the mast carries a detector device and collecting mast scanned information. A power supply is carried by one or more of the mounting support assembly or the detector device and is connected to the detector device. A communications device is carried by one or more of the mounting support assembly or the detector device and is connected to the detector device for receiving and relaying the collected mast scanned information.
Abstract:
A medical imaging system including an imaging device and a patient positioning area in close proximity to the imaging device. A protective bumper is attached to, and conforms to a shape of the imaging device. The system may also include a detection system that has a pressure sensing device.
Abstract:
An optical network includes a number of nodes coupled to an optical transmission medium, such as an optical fiber bus. Each of the nodes includes a dark pulse generator. Different nodes output dark pulses in different time slots onto the transmission medium, forming a dark pulse OTDM (optical time division multiplexed) signal. The network may have a re-entrant bus topology.
Abstract:
This invention relates to compounds of formula (I), ##STR1## pharmaceutically acceptable salt thereof, and pharmaceutically acceptable solvates of either entity, wherein X is CH or N; Y is optionally monousaturated C.sub.3 -C.sub.5 alkylene optionally substituted with C.sub.1 -C.sub.4 alkyl or methylene; R.sup.1 is H; C.sub.1 -C.sub.4 alkyl optionally substituted with C.sub.1 -C.sub.4 alkoxy, OH, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, C.sub.3 -C.sub.6 cycloalkyl or aryl; or C.sub.3 -C.sub.6 alkenyl; R.sup.2 is H; C.sub.1 -C.sub.4 alkyl optionally substituted with C.sub.1 -C.sub.4 alkoxy, OH, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, C.sub.3 -C.sub.6 cycloalkyl or aryl; or CONR.sup.5 R.sup.6 ; R.sup.3 and R.sup.4 are each independently selected from H; C.sub.1 -C.sub.4 alkyl optionally substituted with NR.sup.5 R.sup.6 ; C.sub.1 -C.sub.4 alkoxy; halo; CONR.sup.5 R.sup.6 and aryl; R.sup.5 and R.sup.6 are each independently selected from H and C.sub.1 -C.sub.4 alkyl; and m and n are each independently 1, 2 or 3; are potent and selective thrombin inhibitors useful in the treatment of, inter alia, deep vein thrombosis; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; restenosis and occlusion following angioplasty; or neurodegenerative disorders.