Compounds which have activity at M1 receptor and their uses in medicine
    13.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 有权
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号:US08283364B2

    公开(公告)日:2012-10-09

    申请号:US12088465

    申请日:2006-09-27

    IPC分类号: A61K31/454 C07D405/04

    CPC分类号: C07D405/12 C07D235/26

    摘要: Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译: 提供式(I)和盐的化合物:其中R 4是氟,R 5选自氢,卤素,氰基,C 1-6烷基,被一个或多个氟原子取代的C 1-6烷基,C 1-6烷氧基和C 1-6烷氧基取代 具有一个或多个氟原子; 并且R 6选自卤素,氰基,C 1-6烷基,被一个或多个氟原子取代的C 1-6烷基,C 3-6环烷基,被一个或多个氟原子取代的C 3-6环烷基,C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基 更多的氟原子,Q是氢或C 1-6烷基。 预期化合物可用于治疗,例如治疗精神病和认知障碍。