公开(公告)号：US20050016926A1

公开(公告)日：2005-01-27

申请号：US10626501

申请日：2003-07-24

Applicant: Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

Inventor： Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

IPC: A61K47/44 ,  B01D15/08 ,  B01D15/32

CPC classification number: C07D305/14 ,  A61K47/44 ,  B01D15/325 ,  B01J20/287

Abstract: A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.

Abstract translation: 公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。 使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

公开(公告)号：US06365191B1

公开(公告)日：2002-04-02

申请号：US09667417

申请日：2000-09-21

Applicant: Anand C. Burman ,  Rama Mukherjee ,  Dhiraj Khattar ,  Mukesh Kumar ,  Honey Bala ,  Rajiv Kumar Shrivastava

Inventor： Anand C. Burman ,  Rama Mukherjee ,  Dhiraj Khattar ,  Mukesh Kumar ,  Honey Bala ,  Rajiv Kumar Shrivastava

IPC: A61K914

CPC classification number: A61K9/5138 ,  A61K9/1075 ,  A61K31/337 ,  Y10S977/906

Abstract: This invention relates to pharmaceutical formulations of paclitaxel, its derivatives or analogs entrapped into nanoparticles of co-polymeric micelles, a process for preparing the same and the use thereof.

Abstract translation: 本发明涉及包埋在共聚合胶束纳米颗粒中的紫杉醇，其衍生物或类似物的药物制剂，其制备方法及其用途。

公开(公告)号：US09872873B2

公开(公告)日：2018-01-23

申请号：US14377047

申请日：2012-03-29

Applicant: Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

Inventor： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

IPC: A61K31/706 ,  A61K47/02 ,  A61K47/26 ,  A61K31/4184 ,  A61K9/19 ,  A61K9/00

CPC classification number: A61K31/706 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/4184 ,  A61K47/02 ,  A61K47/26

Abstract: The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.

公开(公告)号：US20140378407A1

公开(公告)日：2014-12-25

申请号：US14377047

申请日：2012-03-29

Applicant: Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

Inventor： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

IPC: A61K31/706 ,  A61K47/02 ,  A61K47/26 ,  A61K31/4184 ,  A61K9/19

CPC classification number: A61K31/706 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/4184 ,  A61K47/02 ,  A61K47/26

Abstract: The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.

Abstract translation: 本发明涉及一种制备易于水解的化合物的稳定药物组合物的方法，其包括a。 在配制容器中，任选地在注射用水中加入所需量的药学上可接受的冻干赋形剂; b。 加入有机溶剂形成适当比例的水和有机溶剂; C。 将制剂容器的温度保持在-5±1℃至-5±3℃的范围内。 d。 加入所需量的易水解的化合物形成溶液并冻干该溶液。

公开(公告)号：US20110301189A1

公开(公告)日：2011-12-08

申请号：US13151721

申请日：2011-06-02

Applicant: Dhiraj Khattar ,  Rajesh Khanna ,  Poonam Singla ,  Abhilasha Yadav ,  Vinay Gupta ,  Rajesh Kini ,  Sushil Kumar Dubey

Inventor： Dhiraj Khattar ,  Rajesh Khanna ,  Poonam Singla ,  Abhilasha Yadav ,  Vinay Gupta ,  Rajesh Kini ,  Sushil Kumar Dubey

IPC: A61K31/436 ,  A61P35/00 ,  C07D491/153

CPC classification number: A61K9/0019 ,  A61K31/436 ,  A61K47/10 ,  A61K47/12

Abstract: A stable pharmaceutical compositions of Rapamycin Esters, in particular Rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid that is free of antioxidants and a process of preparing the same.

Abstract translation: 雷帕霉素酯的稳定药物组合物，特别是不含抗氧化剂的3-羟基-2-（羟甲基）-2-甲基丙酸的雷帕霉素42-酯及其制备方法。

公开(公告)号：US20060226076A1

公开(公告)日：2006-10-12

申请号：US11449476

申请日：2006-06-08

Applicant: Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

Inventor： Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

IPC: B01D15/08

CPC classification number: C07D305/14 ,  A61K47/44 ,  B01D15/325 ,  B01J20/287

Abstract: A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.

Abstract translation: 公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。 使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

公开(公告)号：US20060159783A1

公开(公告)日：2006-07-20

申请号：US11219482

申请日：2005-09-02

Applicant: Rama Mukherjee ,  Dhiraj Khattar ,  Manu Jaggi ,  Anu Singh ,  Mukesh Kumar ,  Honey Bala

Inventor： Rama Mukherjee ,  Dhiraj Khattar ,  Manu Jaggi ,  Anu Singh ,  Mukesh Kumar ,  Honey Bala

IPC: A61K36/906

CPC classification number: A61K31/56 ,  A61K36/725

Abstract: This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.

Abstract translation: 本发明涉及具有广谱抗癌活性的口服有效的草药提取物组合物，更具体地，涉及治疗，抑制和/或预防结肠，肠，胃，乳腺，黑素瘤，成胶质细胞瘤，肺，子宫颈恶性肿瘤的方法 ，卵巢，前列腺，口腔，喉，肝，胰腺，肾，膀胱，内皮细胞，白血病和骨髓瘤，使用梓属的草药提取物，富含桦木酸。 提取物的优点是桦木酸具有低的全身毒性。 提取物抑制癌细胞的蛋白激酶C活性并诱导细胞凋亡。

公开(公告)号：US06656970B2

公开(公告)日：2003-12-02

申请号：US09802293

申请日：2001-03-08

Applicant: Anand C. Burman ,  Rama Mukherjee ,  Honey Bala ,  Dhiraj Khattar

Inventor： Anand C. Burman ,  Rama Mukherjee ,  Honey Bala ,  Dhiraj Khattar

IPC: A61K3120

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K31/19 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26

Abstract: The present invention provides compositions and methods for the solubilization of poorly soluble drugs such as triterpenes like betulinic acid and/its derivatives in pharmaceutically acceptable liquid vehicles that avoid use of potentially toxic solvents that are often used for the solubilization of poorly soluble drugs. In the compositions of this invention the drugs remain physically and chemically stable and can be administered intravascularly without undue toxicity from undissolved drug and/or from the solvent vehicles at a drug dose meant to be effective to exhibit clinically significant anticancer activity.