-
公开(公告)号：US20070149484A1
公开(公告)日：2007-06-28
申请号：US11558503
申请日：2006-11-10
申请人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
发明人： Eckhard Claus , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Michael Czech , Tilmann Schuster
IPC分类号： A61K31/675 , C07D487/02 , A61K31/498
CPC分类号： A61K31/4985 , A61K31/5377 , A61K31/675 , A61K31/695 , C07D487/04
摘要： The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
摘要翻译： 本发明涉及通式（I）和（II）的新型吡啶并[2,3-b]吡嗪衍生物及其作为药物的制备和用途，特别是用于治疗基于病理细胞的恶性疾病和其它病症 激增。
-
![Modulating signal transduction pathways with substituted pyridol [2,3-b] pyrazines](/abs-image/US/2013/09/17/US08536332B2/abs.jpg.150x150.jpg)
12.发明授权Modulating signal transduction pathways with substituted pyridol [2,3-b] pyrazines 失效用取代的吡啶并[2,3-b]吡嗪调节信号转导通路公开(公告)号：US08536332B2
公开(公告)日：2013-09-17
申请号：US13455187
申请日：2012-04-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： Method of modulating ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and/or SAPK signal transduction pathway with a pyrido[2,3-b]pyrazine of formula (Ia).
摘要翻译： 用式（Ia）的吡啶并[2,3-b]吡嗪调节ras-Raf-Mek-Erk信号转导途径，PI3K-Akt信号转导途径和/或SAPK信号转导途径的方法。
-
公开(公告)号：US08461178B2
公开(公告)日：2013-06-11
申请号：US12953680
申请日：2010-11-24
申请人： Tilmann Schuster , Matthias Gerlach , Irene Seipelt , Emmanuel Polymeropoulos , Gilbert Mueller , Eckhard Guenther , Pascal Marchand , Julien Defaux
发明人： Tilmann Schuster , Matthias Gerlach , Irene Seipelt , Emmanuel Polymeropoulos , Gilbert Mueller , Eckhard Guenther , Pascal Marchand , Julien Defaux
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyrosine and serine/threonine kinases and for the treatment of malignant or benign tumors and other disorders based on pathological cell proliferation, such as, for example, restenosis, psoriasis, arteriosclerosis and cirrhosis of the liver.
摘要翻译： 本发明涉及萘啶类型的激酶调节剂以及其作为用于调节错误定向的细胞信号转导过程的药物的制备和用途，特别是用于影响酪氨酸和丝氨酸/苏氨酸激酶的功能以及治疗恶性或 良性肿瘤和基于病理性细胞增殖的其它病症，例如再狭窄，牛皮癣，动脉硬化和肝硬化。
-
14.发明授权Quinoxaline derivatives and their use for treating benign and malignant tumour disorders 失效喹喔啉衍生物及其用于治疗良性和恶性肿瘤疾病的用途公开(公告)号：US08394801B2
公开(公告)日：2013-03-12
申请号：US12731243
申请日：2010-03-25
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Tilmann Schuster , Emmanuel Polymeropoulos , Michael Czech , Eckhard Claus
IPC分类号： A61K31/495
CPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D409/12 , C07D413/12
摘要： The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.
摘要翻译： 本发明提供了通式I的喹喔啉，其用作优选用于治疗肿瘤病症的药物，特别是在对其它活性化合物的耐药性和转移性癌症的情况下。 可能的应用不限于肿瘤病症。
-
公开(公告)号：US20120277219A1
公开(公告)日：2012-11-01
申请号：US13542101
申请日：2012-07-05
申请人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
发明人： Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
IPC分类号： A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P35/00 , A61P29/00 , A61P19/02 , A61P31/18 , A61P25/28 , A61P17/06 , A61P37/02 , A61P35/02 , A61P3/10 , A61P37/06 , A61P11/06 , A61P1/00 , A61P9/10 , A61P9/00 , A61P13/12 , A61P7/02 , A61P3/04 , A61P9/12 , A61K31/538
CPC分类号： C07D471/04
摘要： The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
-
16.发明申请公开(公告)号：US20110150831A1
公开(公告)日：2011-06-23
申请号：US12953680
申请日：2010-11-24
申请人： Tilmann SCHUSTER , Matthias GERLACH , Irene SEIPELT , Emmanuel POLYMEROPOULOS , Gilbert MUELLER , Eckhard GUENTHER , Pascal MARCHAND , Julien DEFAUX
发明人： Tilmann SCHUSTER , Matthias GERLACH , Irene SEIPELT , Emmanuel POLYMEROPOULOS , Gilbert MUELLER , Eckhard GUENTHER , Pascal MARCHAND , Julien DEFAUX
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/5377 , A61K31/444 , A61K38/46 , A61K38/14 , A61K33/24 , A61K31/675 , A61K31/7068 , A61K31/704 , A61K31/7048 , A61K38/21 , A61K39/395 , A61K38/12 , A61K31/655 , A61K31/7076 , A61P9/10 , A61P1/16 , A61P17/06 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyrosine and serine/threonine kinases and for the treatment of malignant or benign tumours and other disorders based on pathological cell proliferation, such as, for example, restenosis, psoriasis, arteriosclerosis and cirrhosis of the liver.
摘要翻译： 本发明涉及萘啶类型的激酶调节剂以及其作为用于调节错误定向的细胞信号转导过程的药物的制备和用途，特别是用于影响酪氨酸和丝氨酸/苏氨酸激酶的功能以及治疗恶性或 良性肿瘤和基于病理性细胞增殖的其它病症，例如再狭窄，牛皮癣，动脉硬化和肝硬化。
-
公开(公告)号：US20070123494A1
公开(公告)日：2007-05-31
申请号：US11558493
申请日：2006-11-10
申请人： Irene SEIPELT , Eckhard Claus , Eckhard Guenther , Tilmann Schuster , Michael Czech , Emmanuel Polymeropoulos
发明人： Irene SEIPELT , Eckhard Claus , Eckhard Guenther , Tilmann Schuster , Michael Czech , Emmanuel Polymeropoulos
IPC分类号： A61K31/5415 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/498 , C07D487/02
CPC分类号： A61K45/06 , A61K31/4985 , C07D471/04
摘要： The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.
摘要翻译： 本发明提供了适用于治疗或预防由哺乳动物，特别是人类中的信号转导途径和/或酶介导和/或调节的生理和/或病理生理状态的新的吡啶并吡嗪化合物。
-
18.发明申请Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone 失效喹啉，异喹啉和酞嗪衍生物作为促性腺激素释放激素的拮抗剂公开(公告)号：US20050004127A1
公开(公告)日：2005-01-06
申请号：US10896961
申请日：2004-07-23
申请人： Peter Strehlke , Peter Droescher , Ulrich Buehmann , Norbert Schmees , Peter Muhn , Holger Hess-Stumpp , Roland Kuhne , Eckhard Guenther , Emmanuel Polymeropoulos , Antonius Ter Laak
发明人： Peter Strehlke , Peter Droescher , Ulrich Buehmann , Norbert Schmees , Peter Muhn , Holger Hess-Stumpp , Roland Kuhne , Eckhard Guenther , Emmanuel Polymeropoulos , Antonius Ter Laak
IPC分类号： A61K31/47 , A61P5/02 , C07D215/56 , C07D237/32 , C07D401/04 , C07D401/12 , C07D409/04 , A61K31/502 , A61K31/517
CPC分类号： C07D401/04 , A61K31/47 , C07D215/56 , C07D237/32 , C07D401/12 , C07D409/04
摘要： The invention relates to new quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone.
摘要翻译： 本发明涉及作为促性腺激素释放激素拮抗剂的新喹啉，异喹啉和酞嗪衍生物。
-
公开(公告)号：US08937068B2
公开(公告)日：2015-01-20
申请号：US11558493
申请日：2006-11-10
申请人： Irene Seipelt , Eckhard Claus , Eckhard Guenther , Tilmann Schuster , Michael Czech , Emmanuel Polymeropoulos
发明人： Irene Seipelt , Eckhard Claus , Eckhard Guenther , Tilmann Schuster , Michael Czech , Emmanuel Polymeropoulos
IPC分类号： A61K31/4985 , C07D471/04 , C07D519/00 , A61K45/06
CPC分类号： A61K45/06 , A61K31/4985 , C07D471/04
摘要： Pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans. A compound according to the general formula (I)
摘要翻译： 吡啶并吡嗪类化合物，其适用于治疗或预防由哺乳动物，特别是人类中的信号转导途径和/或酶介导和/或调节的生理和/或病理生理状态。 根据通式（I）的化合物，
-
20.发明授权公开(公告)号：US08541462B2
公开(公告)日：2013-09-24
申请号：US13358055
申请日：2012-01-25
申请人： Tilmann Schuster , Klaus Paulini , Peter Schmidt , Silke Baasner , Emmanuel Polymeropoulos , Eckhard Guenther , Michael Teifel
发明人： Tilmann Schuster , Klaus Paulini , Peter Schmidt , Silke Baasner , Emmanuel Polymeropoulos , Eckhard Guenther , Michael Teifel
IPC分类号： A61K31/403 , C07D209/82
CPC分类号： C07K5/06191 , A61K38/00 , C07K5/0827
摘要： The present invention provides novel tetrahydrocarbazole compounds according to formula (I) as ligands of G-protein coupled receptors (GPCR) which are useful in the treatment and/or prophylaxis of physiological and/or pathological conditions in mammals mediated by GPCR or of physiological and/or pathological conditions which can be treated by modulation of these receptors.
摘要翻译： 本发明提供了根据式（I）的新型四氢咔唑化合物作为G蛋白偶联受体（GPCR）的配体，其可用于治疗和/或预防由GPCR介导的哺乳动物的生理和/或病理状况或生理和/ /或可以通过调节这些受体来治疗的病理状况。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.038 秒)
