公开(公告)号：US08003682B2

公开(公告)日：2011-08-23

申请号：US12311787

申请日：2007-10-17

Applicant: Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert Boutin ,  Valérie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

Inventor： Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert Boutin ,  Valérie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

IPC: A61K31/4045 ,  C07D209/12

CPC classification number: C07D209/42

Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 represents a linear or branched (C1-C6)alkyl group, and n represents from 1 to 6. Medicaments.

Abstract translation: 式（I）化合物：其中：R1表示烷基，环烷基或环烷基烷基，R2表示直链或支链（C1-C6）烷基，n表示1-6。药物。

公开(公告)号：US20100204276A1

公开(公告)日：2010-08-12

申请号：US12311805

申请日：2007-10-17

Applicant: Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert Boutin ,  Valerie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

Inventor： Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert Boutin ,  Valerie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

IPC: A61K31/454 ,  C07D401/02 ,  A61P25/00 ,  A61P25/22 ,  A61P1/00 ,  A61P9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3, together with the nitrogen atom carrying them, form a heterocycle having from 5 to 8 ring members, and n represents from 2 to 6. Medicinal products containing the same which are useful in treating disorders of the to melatoninergic system.

Abstract translation: 式（I）的化合物：其中：R1表示烷基，环烷基或环烷基烷基，R2和R3与携带它们的氮原子一起形成具有5至8个环成员的杂环，n表示2-6。 含有该药物的药物可用于治疗褪黑激素系统的病症。

公开(公告)号：US08461178B2

公开(公告)日：2013-06-11

申请号：US12953680

申请日：2010-11-24

Applicant: Tilmann Schuster ,  Matthias Gerlach ,  Irene Seipelt ,  Emmanuel Polymeropoulos ,  Gilbert Mueller ,  Eckhard Guenther ,  Pascal Marchand ,  Julien Defaux

Inventor： Tilmann Schuster ,  Matthias Gerlach ,  Irene Seipelt ,  Emmanuel Polymeropoulos ,  Gilbert Mueller ,  Eckhard Guenther ,  Pascal Marchand ,  Julien Defaux

IPC: A61K31/44 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyrosine and serine/threonine kinases and for the treatment of malignant or benign tumors and other disorders based on pathological cell proliferation, such as, for example, restenosis, psoriasis, arteriosclerosis and cirrhosis of the liver.

Abstract translation: 本发明涉及萘啶类型的激酶调节剂以及其作为用于调节错误定向的细胞信号转导过程的药物的制备和用途，特别是用于影响酪氨酸和丝氨酸/苏氨酸激酶的功能以及治疗恶性或 良性肿瘤和基于病理性细胞增殖的其它病症，例如再狭窄，牛皮癣，动脉硬化和肝硬化。

公开(公告)号：US20110150831A1

公开(公告)日：2011-06-23

申请号：US12953680

申请日：2010-11-24

Applicant: Tilmann SCHUSTER ,  Matthias GERLACH ,  Irene SEIPELT ,  Emmanuel POLYMEROPOULOS ,  Gilbert MUELLER ,  Eckhard GUENTHER ,  Pascal MARCHAND ,  Julien DEFAUX

Inventor： Tilmann SCHUSTER ,  Matthias GERLACH ,  Irene SEIPELT ,  Emmanuel POLYMEROPOULOS ,  Gilbert MUELLER ,  Eckhard GUENTHER ,  Pascal MARCHAND ,  Julien DEFAUX

IPC: A61K31/4375 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/444 ,  A61K38/46 ,  A61K38/14 ,  A61K33/24 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/21 ,  A61K39/395 ,  A61K38/12 ,  A61K31/655 ,  A61K31/7076 ,  A61P9/10 ,  A61P1/16 ,  A61P17/06 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyrosine and serine/threonine kinases and for the treatment of malignant or benign tumours and other disorders based on pathological cell proliferation, such as, for example, restenosis, psoriasis, arteriosclerosis and cirrhosis of the liver.

Abstract translation: 本发明涉及萘啶类型的激酶调节剂以及其作为用于调节错误定向的细胞信号转导过程的药物的制备和用途，特别是用于影响酪氨酸和丝氨酸/苏氨酸激酶的功能以及治疗恶性或 良性肿瘤和基于病理性细胞增殖的其它病症，例如再狭窄，牛皮癣，动脉硬化和肝硬化。

公开(公告)号：US20100063128A1

公开(公告)日：2010-03-11

申请号：US12311787

申请日：2007-10-17

Applicant: Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert ,  Valerie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

Inventor： Pascal Marchand ,  Vincent Babonneau ,  Sylvie Piessard ,  Muriel Duflos ,  Jean Albert ,  Valerie Audinot ,  Philippe Delagrange ,  Daniel-Henri Caignard

IPC: A61K31/403 ,  C07D209/04

CPC classification number: C07D209/42

Abstract: Compounds of formula (I): wherein:R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group,R2 represents a linear or branched (C1-C6)alkyl group,and n represents from 1 to 6.

Abstract translation: 式（I）化合物：其中：R1表示烷基，环烷基或环烷基烷基，R2表示直链或支链（C1-C6）烷基，n表示1至6。