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11.METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 有权
标题翻译: 用于抑制过渡性内皮细胞ATPase的方法和组合物公开(公告)号:US20110288082A1
公开(公告)日:2011-11-24
申请号:US13103003
申请日:2011-05-06
申请人: Raymond J. Deshaies , Tsui-Fen Chou , Frank J. Schoenen , Kelin Li , Kevin J. Frankowski , Jeffrey Aube , Samuel W. Gerritz , Han-Jie Zhou
发明人: Raymond J. Deshaies , Tsui-Fen Chou , Frank J. Schoenen , Kelin Li , Kevin J. Frankowski , Jeffrey Aube , Samuel W. Gerritz , Han-Jie Zhou
IPC分类号: A61K31/538 , A61K31/53 , A61K31/4184 , C40B30/08 , C12Q1/34 , C07D239/95 , C07D413/04 , C07D403/04 , C07D495/04 , C07D401/04 , C07D417/04 , C07D409/12 , C07D417/12 , C07D413/14 , C07D401/14 , A61P43/00 , A61K31/517
CPC分类号: A61K31/517 , A61K31/4184 , A61K31/53 , A61K31/538 , C12Q1/42 , C12Q1/485 , G01N2500/02
摘要: Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof
摘要翻译: 式I-XLIII的化合物被鉴定为p97 ATPase的直接抑制剂或p97依赖性泛素 - 蛋白酶体系统(UPS)底物的降解。 公开了用于抑制p97 ATP酶和p97依赖性UPS底物的降解以及鉴定其抑制剂的方法和组合物
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12.INDOLE, BENZIMIDAZOLE, AND BENZOLACTAM BORONIC ACID COMPOUNDS, ANALOGS THEREOF AND METHODS OF USE THEREOF 审中-公开
标题翻译: 吲哚,苯并咪唑和苯并咪唑硼酸化合物,其模拟物及其使用方法公开(公告)号:US20090264384A1
公开(公告)日:2009-10-22
申请号:US12268237
申请日:2008-11-10
申请人: John R. Didsbury , Tatyana Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessy Matthew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss , James F. Burns , Leonard A. Cabana , Glenn C. Collupy , David N. Vanvliet
发明人: John R. Didsbury , Tatyana Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessy Matthew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss , James F. Burns , Leonard A. Cabana , Glenn C. Collupy , David N. Vanvliet
IPC分类号: A61K31/69 , A61P1/00 , A61P19/02 , A61P17/06 , A61P11/06 , A61P11/00 , A61P17/00 , A61P37/08
CPC分类号: A61K31/69 , Y02A50/411
摘要: Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译: 还描述了苯并咪唑,吲哚和苯并内酰胺硼酸化合物,其类似物和药物制剂,以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α(TNF-α)的方法。
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公开(公告)号:US20080319044A1
公开(公告)日:2008-12-25
申请号:US11718286
申请日:2005-10-27
申请人: John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss
发明人: John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss
IPC分类号: A61K31/404 , C07D209/04 , A61P1/00 , A61P19/02 , A61P17/06 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00 , A61P9/12 , A61P15/10
CPC分类号: C07D491/04 , C07D209/08 , C07F5/025
摘要: Indole boronic acid compounds, and analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译: 描述了吲哚硼酸化合物及其类似物和药物制剂,以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α(TNF-α)的方法。
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