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公开(公告)号：US20080319044A1
公开(公告)日：2008-12-25
申请号：US11718286
申请日：2005-10-27
申请人： John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss
发明人： John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss
IPC分类号： A61K31/404 , C07D209/04 , A61P1/00 , A61P19/02 , A61P17/06 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00 , A61P9/12 , A61P15/10
CPC分类号： C07D491/04 , C07D209/08 , C07F5/025
摘要： Indole boronic acid compounds, and analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译： 描述了吲哚硼酸化合物及其类似物和药物制剂，以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。
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公开(公告)号：US20090005344A1
公开(公告)日：2009-01-01
申请号：US11718277
申请日：2005-10-27
申请人： James F. Burns , Leonardo A. Cabana , Glenn C. Collupy , John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , David S. Van Vliet , David Middlemiss
发明人： James F. Burns , Leonardo A. Cabana , Glenn C. Collupy , John R. Didsbury , Tatyana A. Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessymol Mathew , Frank J. Schoenen , David S. Van Vliet , David Middlemiss
IPC分类号： A61K31/4184 , A61K31/381 , A61P43/00 , A61P29/00 , A61P19/02 , A61P17/06 , A61P19/08 , A61P11/06
CPC分类号： C07F5/025 , C07D235/18 , C07D417/04
摘要： Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译： 描述了咪唑和苯并咪唑硼酸化合物，其类似物和药物制剂，以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。
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3.发明申请INDOLE, BENZIMIDAZOLE, AND BENZOLACTAM BORONIC ACID COMPOUNDS, ANALOGS THEREOF AND METHODS OF USE THEREOF 审中-公开吲哚，苯并咪唑和苯并咪唑硼酸化合物，其模拟物及其使用方法公开(公告)号：US20090264384A1
公开(公告)日：2009-10-22
申请号：US12268237
申请日：2008-11-10
申请人： John R. Didsbury , Tatyana Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessy Matthew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss , James F. Burns , Leonard A. Cabana , Glenn C. Collupy , David N. Vanvliet
发明人： John R. Didsbury , Tatyana Dyakonov , Simon N. Haydar , Michael L. Jones , Francine F. Li , Christopher J. Markworth , Jessy Matthew , Frank J. Schoenen , Jan J. Scicinski , David Middlemiss , James F. Burns , Leonard A. Cabana , Glenn C. Collupy , David N. Vanvliet
IPC分类号： A61K31/69 , A61P1/00 , A61P19/02 , A61P17/06 , A61P11/06 , A61P11/00 , A61P17/00 , A61P37/08
CPC分类号： A61K31/69 , Y02A50/411
摘要： Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译： 还描述了苯并咪唑，吲哚和苯并内酰胺硼酸化合物，其类似物和药物制剂，以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。
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公开(公告)号：US20100016360A1
公开(公告)日：2010-01-21
申请号：US12504547
申请日：2009-07-16
申请人： Simon N. Haydar , Chiara Ghiron , Michela Valacchi , Ugo Zanelli
发明人： Simon N. Haydar , Chiara Ghiron , Michela Valacchi , Ugo Zanelli
IPC分类号： A61K31/4545 , C07D401/12 , A61P25/18 , A61P25/28
CPC分类号： C07D231/12 , C07D213/75 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04
摘要： The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
摘要翻译： 本发明提供化合物和组合物，制备它们的方法，以及使用它们调节α7烟碱乙酰胆碱受体和/或治疗多种疾病，疾病和病症中的任何一种的方法。 提供的化合物可以影响神经系统，精神和/或炎症系统。
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公开(公告)号：US20100130474A1
公开(公告)日：2010-05-27
申请号：US12503997
申请日：2009-07-16
申请人： Hendrick Bothmann , Chiara Ghiron , Laura Maccari , Iolanda Micco , Arianna Nencini , Riccardo Zanaletti , Simon N. Haydar
发明人： Hendrick Bothmann , Chiara Ghiron , Laura Maccari , Iolanda Micco , Arianna Nencini , Riccardo Zanaletti , Simon N. Haydar
IPC分类号： A61K31/551 , C07D243/08 , C07D403/12 , C07D281/06 , A61K31/55 , A61K31/553 , A61P25/00
CPC分类号： C07D401/04 , C07D231/40 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.
摘要翻译： 本发明提供了化合物和组合物，制备方法，以及使用它们调节α7烟碱乙酰胆碱受体和/或治疗各种疾病，疾病和病症中的任何一种的方法。 提供的化合物可以影响神经，精神和/或炎症系统。
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公开(公告)号：US07538084B2
公开(公告)日：2009-05-26
申请号：US10802013
申请日：2004-03-16
申请人： Bruce F. Molino , Simon N. Haydar , Zhicai Yang , Peter C. Michels , Michael S. Hemenway , Joseph O. Rich , Yuri Khmelnitsky
发明人： Bruce F. Molino , Simon N. Haydar , Zhicai Yang , Peter C. Michels , Michael S. Hemenway , Joseph O. Rich , Yuri Khmelnitsky
IPC分类号： A61K38/00
CPC分类号： C07K7/645
摘要： The compounds of the present invention are represented by the chemical structure found in Formula I: Formula I where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof, with R0, R1, B, C, D, E, F, G, H, I, J, and K defined herein.
摘要翻译： 本发明的化合物由式I中所示的化学结构表示：
公式I 其中A是式II的氨基酸： 或其药学上可接受的盐与本文定义的R0，R1，B，C，D，E，F，G，H，I，J和K. -
公开(公告)号：US20080194637A1
公开(公告)日：2008-08-14
申请号：US11982708
申请日：2007-11-02
IPC分类号： A61K31/4965 , A61K31/655 , C07D333/56
CPC分类号： C07D409/14 , C07D333/70 , C07D409/12
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
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公开(公告)号：US20100016598A1
公开(公告)日：2010-01-21
申请号：US12504546
申请日：2009-07-16
申请人： Michela Valacchi , Simon N. Haydar
发明人： Michela Valacchi , Simon N. Haydar
IPC分类号： C07D213/36 , C07D211/16
CPC分类号： C07D401/12
摘要： The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
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9.发明申请COMPOUNDS USEFUL AS ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS 审中-公开化合物有效用作ALPHA7 NICOTINIC乙酰胆碱受体激动剂公开(公告)号：US20090181952A1
公开(公告)日：2009-07-16
申请号：US12353804
申请日：2009-01-14
IPC分类号： A61K31/5513 , C07D403/12
CPC分类号： C07D403/12
摘要： The present invention provides compounds and compositions, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.
摘要翻译： 本发明提供了化合物和组合物以及使用它们调节α7烟碱乙酰胆碱受体和/或治疗各种疾病，疾病和病症中的任何一种的方法。 提供的化合物可以影响神经，精神和/或炎症系统。
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公开(公告)号：US06747039B2
公开(公告)日：2004-06-08
申请号：US10096421
申请日：2002-03-12
申请人： Simon N. Haydar
发明人： Simon N. Haydar
IPC分类号： A61K31435
CPC分类号： C07D495/16
摘要： The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and methods of treating tumors and cancer in mammals with the compounds of the present invention are also disclosed.
摘要翻译： 本发明涉及一组具有抗肿瘤活性的氮杂蒽环唑类化合物及其制备方法。 还公开了含有氮杂蒽环唑化合物的组合物和用本发明化合物治疗哺乳动物肿瘤和癌症的方法。
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