公开(公告)号：US20110201520A1

公开(公告)日：2011-08-18

申请号：US13081306

申请日：2011-04-06

Applicant: Hideo Akiyama ,  Satoko Kozono ,  Akira Myomoto ,  Osamu Nomura ,  Hitoshi Nobumasa ,  Yoshinori Tanaka ,  Shiori Tomoda ,  Yutaka Shimada ,  Gozoh Tsujimoto

Inventor： Hideo Akiyama ,  Satoko Kozono ,  Akira Myomoto ,  Osamu Nomura ,  Hitoshi Nobumasa ,  Yoshinori Tanaka ,  Shiori Tomoda ,  Yutaka Shimada ,  Gozoh Tsujimoto

IPC: C40B30/04 ,  C12Q1/68

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.

Abstract translation: 本发明涉及包含多核苷酸和抗体作为检测，确定或预测食管癌的存在或转移的探针的组合物，试剂盒或DNA芯片，以及用于检测，确定或预测食管的存在或转移的方法 癌症使用相同。

公开(公告)号：US07932032B2

公开(公告)日：2011-04-26

申请号：US11919679

申请日：2006-05-02

Applicant: Hideo Akiyama ,  Satoko Kozono ,  Akira Myomoto ,  Osamu Nomura ,  Hitoshi Nobumasa ,  Yoshinori Tanaka ,  Shiori Tomoda ,  Yutaka Shimada ,  Gozoh Tsujimoto

Inventor： Hideo Akiyama ,  Satoko Kozono ,  Akira Myomoto ,  Osamu Nomura ,  Hitoshi Nobumasa ,  Yoshinori Tanaka ,  Shiori Tomoda ,  Yutaka Shimada ,  Gozoh Tsujimoto

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.

Abstract translation: 本发明涉及包含多核苷酸和抗体作为检测，确定或预测食管癌的存在或转移的探针的组合物，试剂盒或DNA芯片，以及用于检测，确定或预测食管的存在或转移的方法 癌症使用相同。

公开(公告)号：US20080227802A1

公开(公告)日：2008-09-18

申请号：US11722833

申请日：2005-12-26

Applicant: Gozoh Tsujimoto ,  Yukio Takano ,  Kenji Honda ,  Akito Tanoue

Inventor： Gozoh Tsujimoto ,  Yukio Takano ,  Kenji Honda ,  Akito Tanoue

IPC: A61K31/485

CPC classification number: A61K31/485 ,  A61K31/404 ,  A61K38/095 ,  A61K45/06 ,  A61K2300/00

Abstract: A medicament for suppressing development of tolerance to analgesic effect induced by administration of a narcotic analgesic such as morphine, which comprises an antagonist of the vasopressin receptor 1b as an active ingredient.

Abstract translation: 抑制通过施用麻醉性镇痛药（如吗啡）诱导的镇痛作用耐受性的发展的药物，其包含加压素受体1b的拮抗剂作为活性成分。

公开(公告)号：US08949157B2

公开(公告)日：2015-02-03

申请号：US12274744

申请日：2008-11-20

Applicant: Yasushi Okuno ,  Kei Taneishi ,  Gozoh Tsujimoto

Inventor： Yasushi Okuno ,  Kei Taneishi ,  Gozoh Tsujimoto

IPC: G06F15/18 ,  C40B50/02 ,  G06F19/24 ,  G06F19/00 ,  G06F19/16

CPC classification number: C40B50/02 ,  G06F19/16 ,  G06F19/24 ,  G06F19/706 ,  G06N99/005

Abstract: A data processing method for an estimation of compound-protein interaction using both chemical substance information, such as a chemical property of the compound, and biological information, such as sequence information of genes to rationally and efficiently screen compounds. First space representing space coordinates of a first chemical substance group and second space representing space coordinates of a second chemical substance group are defined, and the first chemical substance group is characterized by a first characteristic amount and the second chemical substance group is characterized by a second characteristic amount, and map transformation of the coordinates of the first space and the coordinates of the second space results in the solution so as to increase the correlation between the first space and the second space using a multivariable analysis technique or a machine learning method.

Abstract translation: 使用化学物质信息（例如化合物的化学性质）和生物信息（例如基因的序列信息）的化合物 - 蛋​​白质相互作用的估计的数据处理方法，以合理且有效地筛选化合物。 定义表示第一化学物质组的空间坐标的第一空间和表示第二化学物质组的空间坐标的第二空间，第一化学物质组的特征在于第一特征量，第二化学物质组的特征在于第二化学物质组 特征量和第一空间的坐标和第二空间的坐标的地图变换得到解，从而使用多变量分析技术或机器学习方法来增加第一空间和第二空间之间的相关性。

公开(公告)号：US20110287112A1

公开(公告)日：2011-11-24

申请号：US13147086

申请日：2010-01-29

Applicant: Osamu Ogawa ,  Gozoh Tsujimoto ,  Eijiro Nakamura ,  Tomomi Kamba ,  Yosuke Shimizu ,  Naoki Terada ,  Toshiya Kanaji ,  Takayuki Maruyama

Inventor： Osamu Ogawa ,  Gozoh Tsujimoto ,  Eijiro Nakamura ,  Tomomi Kamba ,  Yosuke Shimizu ,  Naoki Terada ,  Toshiya Kanaji ,  Takayuki Maruyama

IPC: A61K33/24 ,  A61K31/573 ,  A61K31/566 ,  A61M37/00 ,  A61K31/337 ,  A61P35/00 ,  A61P5/28 ,  A61K31/277 ,  A61K38/09

CPC classification number: A61K31/277 ,  A61K45/06 ,  A61K2300/00

Abstract: A prostate cancer progression inhibitor comprises 4-(4-cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butyric acid, a salt thereof, a solvate thereof, or a prodrug thereof. 4-(4-Cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butyric acid is useful as a prostate cancer progression inhibitor because this butyric acid has, for example, a growth inhibiting effect and a hormone responsiveness recovering effect on prostate cancer that has acquired hormone resistance.

Abstract translation: 前列腺癌进展抑制剂包括4-（4-氰基-2 - {[2-（4-氟-1-萘基）丙酰基]氨基}苯基）丁酸，其盐，其溶剂合物或其前药。 4-（4-氰基-2 - {[2-（4-氟-1-萘基）丙酰基]氨基}苯基）丁酸可用作前列腺癌进展抑制剂，因为该丁酸具有例如生长抑制 效应和激素反应恢复作用对获得激素抵抗的前列腺癌。

公开(公告)号：US20100004275A1

公开(公告)日：2010-01-07

申请号：US12480387

申请日：2009-06-08

Applicant: Gozoh Tsujimoto ,  Yukio Takano ,  Kenji Honda ,  Akito Tanoue

Inventor： Gozoh Tsujimoto ,  Yukio Takano ,  Kenji Honda ,  Akito Tanoue

IPC: A61K31/485

CPC classification number: A61K31/485 ,  A61K31/404 ,  A61K38/095 ,  A61K45/06 ,  A61K2300/00

Abstract: A medicament for suppressing development of tolerance to analgesic effect induced by administration of a narcotic analgesic such as morphine, which comprises an antagonist of the vasopressin receptor 1b as an active ingredient.

Abstract translation: 抑制通过施用麻醉性镇痛药（如吗啡）诱导的镇痛作用耐受性发展的药物，其包含加压素受体1b的拮抗剂作为活性成分。

公开(公告)号：US20080269155A1

公开(公告)日：2008-10-30

申请号：US12049951

申请日：2008-03-17

Applicant: Masateru Yamada ,  Hajimu Kurumatani ,  Tetsuo Sudo ,  Gozoh Tsujimoto

Inventor： Masateru Yamada ,  Hajimu Kurumatani ,  Tetsuo Sudo ,  Gozoh Tsujimoto

IPC: A61K31/7105 ,  A61P13/12

CPC classification number: G01N33/6893 ,  A61K31/00 ,  A61K31/122 ,  A61K31/336 ,  A61K31/352 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/7056 ,  A61K31/711 ,  C07D311/30 ,  C12Q1/6883

Abstract: A novel agent for therapy and/or prevention of kidney diseases as well as a diagnostic method (detection method) of kidney diseases is disclosed. The agent for therapy and/or prevention of kidney diseases comprises as an effective ingredient a substance which inhibits casein kinase 2. The diagnostic method of kidney diseases according to the present invention comprises measuring activity or content of casein kinase 2, or measuring expression amount of casein kinase 2 gene in a sample separated from body.

Abstract translation: 公开了用于治疗和/或预防肾脏疾病的新型药物以及肾脏疾病的诊断方法（检测方法）。 用于治疗和/或预防肾脏疾病的药物包括抑制酪蛋白激酶2的物质作为有效成分。根据本发明的肾脏疾病的诊断方法包括测定酪蛋白激酶2的活性或含量，或测量表达量 从体内分离的样品中的酪蛋白激酶2基因。

公开(公告)号：US07148011B2

公开(公告)日：2006-12-12

申请号：US10380254

申请日：2001-09-21

Applicant: Yuji Sugita ,  Ryoichi Hashida ,  Kaoru Ogawa ,  Tomoko Fujishima ,  Takeshi Nagasu ,  Gozoh Tsujimoto ,  Eiki Takahashi

Inventor： Yuji Sugita ,  Ryoichi Hashida ,  Kaoru Ogawa ,  Tomoko Fujishima ,  Takeshi Nagasu ,  Gozoh Tsujimoto ,  Eiki Takahashi

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/158

Abstract: The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene “2090-05” showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.

Abstract translation: 差异显示法用于寻找在特应性皮炎患者中收集的嗜酸性粒细胞的表达水平在恶化阶段和缓解期不同的基因。 结果，分离出在缓解期患者嗜酸性粒细胞中表达显着增加的基因“2090-05”。 该基因可用于测试过敏性疾病并筛选用于治疗剂的候选化合物用于过敏性疾病。